Congenital Hyperinsulinism News and Research

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Disruption of FOXA2 expression in congenital hyperinsulinism: The role of chromosome 20p11.2 deletions

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24 Aug 2023

Researchers unravel genetic changes in a region that controls the activity of the genome

Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics. A team at the University of Exeter has found genetic changes in a region that controls the activity of the genome, turning on or off genes, and in doing so they have found a key that could unlock other causes of rare conditions.

8 Nov 2022

Experimental device offers glycemic control to hyperinsulinism patients after pancreatectomy

Researchers at Children's Hospital of Philadelphia have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

13 Sep 2021

Novel, highly specific treatment method for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine.

9 Nov 2020

Understanding the genetic background of idiopathic ketotic hypoglycemia

Lisa is two years old. She often gets uneasy--shaking and sweating--especially in the morning. She vomits and refuses to eat. Her mother, Karoline, knows she has to act before Lisa starts to deteriorate.

9 Feb 2020

New review of infants with congenital hyperinsulinism shows surgery benefits

A review of nearly 500 cases of infants with severe congenital hyperinsulinism who underwent partial or near-total removal of their pancreas for persistent hypoglycemia at Children's Hospital of Philadelphia showed that surgeons can cure virtually all patients with the focal, or localized, form of the rare genetic disease.

7 May 2018

Researchers precisely describe effects of frequent genetic mutation in congenital hyperinsulinism

Diabetes is characterized by a deficiency of insulin. The opposite is the case in congenital hyperinsulinism: patients produce the hormone too frequently and in excessive quantities, even if they haven't eaten any carbohydrates.

18 Sep 2017

Rare disease day focuses on new approach to finding treatment

2,200 babies will be born in the UK on 29th February, of which 30 will die of a rare disease before they are five years old.

29 Feb 2016

Study focuses on benefits of human milk for sick newborns

Human milk is infant food, but for sick, hospitalized babies, it's also medicine. That's the central premise of a series of articles in a neonatal nursing journal's special issue focused on human milk for sick newborns.

7 Aug 2014

Newborn babies with transient CHI at risk of developing brain damage due to low blood sugars

Researchers from The University of Manchester studying a rare and potentially lethal childhood disease - which is the clinical opposite of diabetes - have made an important discovery.

From The University of Manchester 13 Jun 2013

Researchers sequence entire gene to identify mutations that cause hyperinsulinism

Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas.

28 Dec 2012

Investigational drug shows promise against most severe form of congenital hyperinsulinism

A pilot study in adolescents and adults has found that an investigational drug shows promise as the first potential medical treatment for children with the severest type of congenital hyperinsulinism, a rare but potentially devastating disease in which gene mutations cause insulin levels to become dangerously high.

2 Aug 2012

Manchester research offers hope for congenital hyperinsulinism treatment

University of Manchester scientists have led an international team to discover new treatments for a rare and potentially lethal childhood disease that is the clinical opposite of diabetes mellitus.

16 Mar 2011