Crohn’s Disease News and Research

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Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.

28 Aug 2023

How have inflammatory bowel disease treatments changed after the introduction of biologics?

Researchers compared changes in inflammatory bowel disease treatment strategies before and after the introduction of biologics in Japan.

24 Aug 2023

Are inflammatory bowel disease patients more at risk of colorectal cancer?

Researchers analyzed data from a large cohort of inflammatory bowel disease patients and looked at the risk and frequency of colorectal cancer.

9 Aug 2023

The effectiveness of psychological therapies in patients with inflammatory bowel disease

Psychological therapies provide short-term improvements in stress, anxiety, depression, and quality-of-life scores in patients with IBD.

8 Aug 2023

Study finds genetic overlap between IBS, gastrointestinal diseases, and psychiatric disorders

Researchers characterized the genetic architecture of IBS and investigated genetic overlap with gastrointestinal and psychiatric phenotypes.

8 Aug 2023

How do dietary patterns influence inflammatory bowel disease?

Researchers used bibliometrics to analyze studies describing the effects of dietary patterns on inflammatory bowel disease (IBD).

7 Aug 2023

Anti-inflammatory nanoparticles show promise in treating inflammatory bowel disease

Chronic inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects.

24 Jul 2023

Is constipation associated with hypertension and cardiovascular events in older Australian adults?

Scientists investigated the association between constipation and cardiovascular events such as angina, myocardial infarction, transient ischemic attack, and stroke, as well as hypertension among a representative population of elderly hospitalized patients in Australia.

11 Jul 2023

Lilly granted MHRA marketing authorization in Great Britain for a ground-breaking UC therapy

Eli Lilly and Company announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation (MA) for mirikizumab (OMVOH®) for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic treatment.

10 Jul 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

The role of the fungal mycobiome in women's health

Researchers discuss the association between human mycobiota and female health.

15 Mar 2023

Study suggests mRNA vaccines decouple SARS-CoV-2 immunity from autoantibody responses observed during acute COVID-19

Researchers investigated whether mRNA technology-based COVID-19 vaccines promote the development of autoantibodies.

14 Mar 2023

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Present-day humans share stronger genetic ties with Neanderthals than previously thought

Like a merchant of old, balancing the weights of two different commodities on a scale, nature can keep different genetic traits in balance as a species evolves over millions of years.

21 Feb 2023

Macrophages suppress Escherichia coli LF82 Gally prophage lytic cycle

Researchers analyze prophages of the LF82 strain of adherent-invasive Escherichia coli to better understand their behavior in vitro and within macrophages.

8 Feb 2023

Researchers devise a novel potential IBD treatment strategy that eliminates pathogenic T cells and encourages the proliferation of regulatory T cells

Researchers investigated the CAMCI strategy as an immunotherapeutic option for inflammatory bowel disease.

31 Jan 2023