Cushing Syndrome News and Research

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New review aims to help clinicians diagnose and manage PCOS

A recent review article in CMAJ explores the state of current knowledge on the diagnosis and treatment of this chronic disorder.

30 Jan 2024

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Sitting atop the kidneys, the adrenal gland plays a pivotal role in maintaining a healthy body. Responding to signals from the brain, the gland secretes hormones that support critical functions like blood pressure, metabolism, and fertility.

21 Nov 2022

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Earwax sampling could be a cheap, effective way to measure stress hormone

A novel method to sample earwax could be a cheap and effective way to measure the hormone cortisol, according to a study led by researchers at UCL and King's College London.

3 Nov 2020

Investigational antidepressant PT150 shows antiviral activity against SARS-CoV-2

In a recent bioRxiv study, an ad hoc multi-institutional research team from the US shows that a novel hormone receptor modulator PT150 has unique and possibly additive antiviral and immunomodulatory effects – highlighting its potential role in the treatment and prophylaxis of coronavirus disease (COVID-19).

14 Jul 2020

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.

10 Nov 2019

Scientists reveal Connshing syndrome as new cause of hypertension

Research led by scientists at the University of Birmingham has revealed a new cause of high blood pressure which could lead to major changes in managing the disease.

21 Apr 2017

Study sheds light on role of Armc5 protein in foetal development and T-cell immune responses

Genetic mutations of the Armc5 gene disrupt foetal development and compromise the immune response.

8 Feb 2017

Young people with Cushing syndrome may be at higher risk for suicide, depression

Children with Cushing syndrome may be at higher risk for suicide as well as for depression, anxiety and other mental health conditions long after their disease has been successfully treated, according to a study by researchers at the National Institutes of Health.

29 Mar 2016

FDA approves Novartis' Ilaris for treatment of active systemic juvenile idiopathic arthritis

Novartis announced that the US Food and Drug Administration has approved Ilaris (canakinumab) for the treatment of active systemic juvenile idiopathic arthritis in patients aged 2 years and older.

10 May 2013

Surgery advised in face of uncertain sinus sampling result in Cushing patients

Surgeons should consider transsphenoidal surgery in patients with Cushing disease caused by adrenocorticotropic hormone overproduction, almost irrespective of the results of inferior petrosal sinus sampling, say US researchers.

10 Jul 2012

Subtle and unspoken clues exchanged by patients, doctors exert an influence on medical care

Subtle and unspoken clues exchanged by patients and doctors exert an influence on medical care, according to a new study by the University of Michigan Health System. Researchers analyzed video recordings of routine checkups and conducted follow-up interviews with participants to help elucidate signals sent and received on both sides of the examination table.

27 Sep 2011

Cushing Syndrome News and Research

New review aims to help clinicians diagnose and manage PCOS

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Earwax sampling could be a cheap, effective way to measure stress hormone

Investigational antidepressant PT150 shows antiviral activity against SARS-CoV-2

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

Scientists reveal Connshing syndrome as new cause of hypertension

Study sheds light on role of Armc5 protein in foetal development and T-cell immune responses

Young people with Cushing syndrome may be at higher risk for suicide, depression

FDA approves Novartis' Ilaris for treatment of active systemic juvenile idiopathic arthritis

Surgery advised in face of uncertain sinus sampling result in Cushing patients

Subtle and unspoken clues exchanged by patients, doctors exert an influence on medical care

Journal highlights toxic nature of herbal medicines

Researchers find cause of severe metabolic disorders

Adrenalectomy shown to benefit those with mild Cushing syndrome

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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