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TSRI scientists develop novel technique for finding drug candidates

Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins.

16 Jun 2016

TSRI chemists identify and design potent therapeutic ‘warheads’ for different diseases

In a pair of related studies, chemists from the Florida campus of The Scripps Research Institute (TSRI) have identified and designed dozens of molecular “warheads” that not only can detect a key biomarker of cancer, but also could be developed into a potent new class of drug candidates for a range of diseases.

13 May 2016

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

A promising approach for watching cell signaling processes in their physiological context: Scientists visualize apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time.

11 May 2016

UC Davis researchers develop Hepatitis virus-like particles to target breast cancer

UC Davis researchers have developed a way to use the empty shell of a Hepatitis E virus to carry vaccines or drugs into the body. The technique has been tested in rodents as a way to target breast cancer, and is available for commercial licensing through UC Davis Office of Research.

4 Feb 2016

UTA researchers map out chemical mechanism of key enzyme found in autism, Alzheimer's and Down syndrome

Biochemists at The University of Texas at Arlington are mapping the catalytic processes of sulfur-oxidizing enzymes to improve understanding of the chemical imbalances found in patients with autism, Alzheimer's disease and Down syndrome.

11 Jan 2016

TSRI scientists discover first-in-class compounds that target persistent tuberculosis

Tuberculosis has been infecting humans for several millennia, making it one of the most horribly successful diseases in history. Today, it is still a major killer, responsible for some 1.5 million deaths each year.

18 Nov 2015

Brain & Behavior Research Foundation to honor nine scientists with Outstanding Achievement Prizes

The Brain & Behavior Research Foundation will honor nine scientists with its 2015 Outstanding Achievement Prizes for their work in schizophrenia, mood disorders, child and adolescent psychiatry, and cognitive neuroscience.

9 Oct 2015

Novel technique may help women and their oncologists choose options for treating breast cancer

Biomedical engineers have demonstrated a proof-of-principle technique that could give women and their oncologists more personalized information to help them choose options for treating breast cancer.

6 Oct 2015

People who eat high protein foods have lower blood pressure and arterial stiffness

Eating foods rich in amino acids could be as good for your heart as stopping smoking or getting more exercise - according to new research from the University of East Anglia.

27 Aug 2015

New research could help reverse side effects of acetaminophen overdose

New research could help reverse deadly side effects caused by excessive doses of the drug acetaminophen, the major ingredient in Tylenol and many other over-the-counter and prescription medicines.

23 Jun 2015

Scientists explain the existence of intrinsic chirality in ordinary nanocrystals

A team of scientists from ITMO University and Trinity College Dublin published first experimental results showing that ordinary nanocrystals possess intrinsic chirality and can be produced under normal conditions as a half-and-half mixture of mirror images of each other.

18 Jun 2015

Latest findings regarding nitric oxide offer new avenues to save lives

Professor Jonathan Stamler's latest findings regarding nitric oxide have the potential to reshape fundamentally the way we think about the respiratory system - and offer new avenues to save lives. It may be time to rewrite the textbooks.

13 Apr 2015

Chaetocin synergistic with TKIs against CML cells

Chaetocin, a mycotoxin that increases oxidative stress, can complement the activity of tyrosine kinase inhibitors in chronic myeloid leukaemia by overcoming innate resistance mediated by secreted bone marrow stromal cytokines and growth factors, researchers report.

14 Nov 2014

Scientists develop synthetic amino acid that can impact 3D structure of bioactive peptides

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side-effects to the patient. Such properties are directly related to the 3D structure of the drug molecule.

1 Sep 2014

Versatile nanoparticles offer wide variety of diagnostic and therapeutic applications

Kit Lam and colleagues from UC Davis and other institutions have created dynamic nanoparticles (NPs) that could provide an arsenal of applications to diagnose and treat cancer.

27 Aug 2014

Virobay announces closing of expanded Series B second tranche financing

Virobay, Inc., a clinical stage pharmaceutical company with a platform of cathepsin protease inhibitors being developed for the treatment of neuropathic pain, autoimmune disease and fibrosis, today announced the closing of an expanded Series B second tranche financing of $8.0 million.

16 Jul 2014

Mother's diet before conception can permanently affect how her child's genes function

A mother's diet before conception can permanently affect how her child's genes function, according to a study published in Nature Communications.

30 Apr 2014

Johns Hopkins neuroscientists identify cause of brain degeneration in Huntington's disease

Working with genetically engineered mice, Johns Hopkins neuroscientists report they have identified what they believe is the cause of the vast disintegration of a part of the brain called the corpus striatum in rodents and people with Huntington's disease: loss of the ability to make the amino acid cysteine.

29 Mar 2014

Findings support development of cysteine protease inhibitors as new drug target for AD

A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer's disease (AD). Moreover, the candidate inhibitor drug has been shown to be safe in humans.

18 Mar 2014

Protein that controls Drosophila nervous system may play role in reversing brain injuries in human

A protein that controls the metamorphosis of the common fruit fly could someday play a role in reversing brain injuries, said Duke University researchers.

28 Feb 2014