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SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Researchers demonstrated that the SARS-CoV-2 viroporins precipitate cytokine storm via the alteration of mitochondrial physiology in severe COVID-19.

24 Feb 2022

Researchers discover a novel group of proteins that exists in all domains of life

Proteins are the "workhorses" in every living cell and constitute the chemical basis of life. These little machines are required to turn food into energy, to manage motion and brain activities and to fight off bacteria and viruses.

17 Feb 2022

SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

A new study shows that the SARS-CoV-2 nucleocapsid protein has unique properties that allow the virus to become more infective in the presence of certain mutations.

11 Feb 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

A new study analyzed new data on the Omicron variant and indicated the altered cell entry pathways compared to other variants.

21 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

Scientists unravel how LPS prevents or promotes development of allergic disease

Immunologists have long been baffled by LPS, the bacterial lipopolysaccharide that helps form the cell walls of Gram-negative bacteria.

5 Jan 2022

In vitro effect of several antiviral drugs against various SARS-CoV-2 variants of concern

An independent study confirms that current and prospective antiviral treatments are effective in inhibiting severe infection from SARS-CoV-2.

4 Jan 2022

New systematic review finds low-quality evidence on the effectiveness of hangover remedies

A new systematic review has found only very low-quality evidence that substances claiming to treat or prevent alcohol-induced hangover work.

3 Jan 2022

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

Gene expression related to liver metabolism altered by spaceflight

The latest findings of a series of studies on mice that examined harmful effects caused by spending time in space show that gene expression related to liver metabolism is altered in response to the space environment.

6 Dec 2021

Study suggests efficacy of SARS-CoV-2 main protease inhibitors is not compromised in current COVID-19 variants

A new study has focussed on assessing the Mpro mutants of newly emerged SARS-CoV-2 variants.

2 Dec 2021

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

A new paper deals with the identification of an antiviral compound that could help in developing additional drugs to help fight COVID-19.

30 Nov 2021

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Researchers found that virus-like particles produced by co-expression of SARS-CoV-2 S, membrane, envelope, and nucleocapsid proteins contain S glycoproteins, which are modified by complex carbohydrates.

29 Nov 2021

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium.

29 Nov 2021

Study finds atazanavir inhibits main SARS-CoV-2 protease

Research shows that ATV has different antiviral activity compared to PAXLOVID™, encouraging further research.

29 Nov 2021

Impact of ultraviolet disinfection on nosocomial transmission of SARS-CoV-2 and other infectious diseases

A new review article determines the role of UV disinfection for nosocomial transmission of COVID-19 and other infectious diseases.

22 Nov 2021

What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

Study suggests rattlesnake venom peptide inhibits SARS-CoV-2 replication and transcription

New research suggests a small cationic peptide known as crotamine may inhibit the replication and transcription of SARS-CoV-2.

12 Nov 2021

Invalidation of potential SARS-CoV-2 protease inhibitors

Researchers identified several structurally disparate compounds that can inhibit the viral protease PLpro and determined whether the identified PLpro inhibitors are truly effective and should be further investigated.

9 Nov 2021

Cysteine News and Research

SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Researchers discover a novel group of proteins that exists in all domains of life

SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Scientists unravel how LPS prevents or promotes development of allergic disease

In vitro effect of several antiviral drugs against various SARS-CoV-2 variants of concern

New systematic review finds low-quality evidence on the effectiveness of hangover remedies

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

Gene expression related to liver metabolism altered by spaceflight

Study suggests efficacy of SARS-CoV-2 main protease inhibitors is not compromised in current COVID-19 variants

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Study finds atazanavir inhibits main SARS-CoV-2 protease

Impact of ultraviolet disinfection on nosocomial transmission of SARS-CoV-2 and other infectious diseases

What genes affect the COVID-19 gender imbalance?

Study suggests rattlesnake venom peptide inhibits SARS-CoV-2 replication and transcription

Invalidation of potential SARS-CoV-2 protease inhibitors

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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