Cytokine News and Research

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New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

In a recent study published in Science Translational Medicine, researchers profile antigen-specific helper clusters of differentiation 4-positive (CD4+) T-lymphocytes to determine anti-islet autoimmunity among mice and humans.

9 Jul 2023

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Persistent immune activation and elevated cytokine levels were observed in patients with severe COVID-19, even months after recovery. However, the correlation between immune activation and long COVID symptoms appeared to be independent, suggesting other factors influencing disease severity.

9 Jul 2023

Unique plant extract mixture has potent anti-acne effects

Researchers evaluate the efficacy of FRO, a formula composed of fermented Rhus verniciflua Stokes and Orostachys japonicus, against acne pathogenesis via antimicrobial assessment and an in vitro analysis. FRO was found to contain phenolics such as gallic acid, fisetin, quercetin, and kaempferol and was determined to alleviate acne by inhibiting the growth of Cutibacterium acnes, inflammation, and excess sebum.

9 Jul 2023

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Research discusses the process of discovering anti-inflammatory and neuroprotective drugs from medicinal plants found in the Australian rainforest. It focuses on the pathways from the discovery of bioactive plants to the validation in an appropriate neuro-inflammatory mouse model, using some examples from their current research.

9 Jul 2023

Using a vaccine to boost the response of engineered T cells

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn't worked as well for solid tumors.

5 Jul 2023

Candidate genes for inflammatory bowel disease identified

A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans. The findings are published as a Reviewed Preprint in eLife.

5 Jul 2023

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Researchers present the mechanisms by which SARS-CoV-2 could infect the brain and affect memory.

5 Jul 2023

Advances in influenza research

This interview with Dr. Mohammad S Safiarian, Associate Product Manager at Sino Biological, discusses the advances in influenza research and how effective vaccines are developed.

From Sino Biological Inc. 30 Jun 2023

Elucidating the role of the gut-brain-axis in autism

The study investigates the relationship between the gut and the brain in autism spectrum disorder (ASD), identifying microbial profiles and metabolic products associated with ASD phenotypes, dietary patterns, and inflammation. The findings provide insights into the role of the gut-brain axis in ASD and its potential impact on understanding and managing the disorder.

28 Jun 2023

First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Cartesian Therapeutics, a clinical-stage biotechnology company pioneering cell therapies for autoimmune diseases, announced today the publication of a landmark paper in The Lancet Neurology.

22 Jun 2023

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.

21 Jun 2023

3D-printed vaginal ovules offer promising treatment for endometriosis

3D-printed vaginal ovules offer controlled release and targeted treatment, showing promise for conditions like endometriosis.

20 Jun 2023

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Chronic obstructive pulmonary disease patients with type 2 inflammation saw rapid and sustained improvements in their disease after treatment with the monoclonal antibody dupilumab, according to a yearlong, Phase 3 clinical trial reported in the New England Journal of Medicine.

20 Jun 2023

Apple-shaped obesity associated with greater inflammation and mortality in COVID-19 patients

Eating an apple a day may keep the doctor away, but having an apple shape is not nearly as healthy. Now, researchers from Japan have shown that people who carry their weight in their bellies may be at greater risk of poor outcomes if they catch COVID-19.

20 Jun 2023

Battle against RSV: Computational design paves way for new polyvalent vaccine

Research focuses on the design of a multi-epitope polyvalent vaccine against Human Respiratory Syncytial Virus (RSV), a leading cause of lower respiratory tract infections. The study utilizes computational methods and immunoinformatics tools to predict potential vaccine candidates and their interactions with Toll-like receptors (TLRs).

19 Jun 2023

Herbal extracts for mental health: Are they safe for pregnant women?

Researchers evaluate the T-cell modulating effects of St. John’s wort, valerian, hops, lavender, and California poppy.

18 Jun 2023

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why.

15 Jun 2023

Molecular insights into long COVID: serum proteome reveals dominant signaling pathways

Researchers examined the serum proteome of unvaccinated adults who had PASC.

15 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Researchers explored the antioxidant and anti-inflammatory properties of bamboo leaves and sheaths.

13 Jun 2023

Cytokine News and Research

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Unique plant extract mixture has potent anti-acne effects

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Using a vaccine to boost the response of engineered T cells

Candidate genes for inflammatory bowel disease identified

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Advances in influenza research

Elucidating the role of the gut-brain-axis in autism

First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

3D-printed vaginal ovules offer promising treatment for endometriosis

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Apple-shaped obesity associated with greater inflammation and mortality in COVID-19 patients

Battle against RSV: Computational design paves way for new polyvalent vaccine

Herbal extracts for mental health: Are they safe for pregnant women?

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Molecular insights into long COVID: serum proteome reveals dominant signaling pathways

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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