Cytokine News and Research

RSS

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Maternal immune cells could bring SARS-CoV-2 to the placenta

Researchers from Canada and Brazil collaborated to explore the possibility of perinatal transmission of the virus from pregnant mothers to their babies and the risk of preterm birth.

30 Sep 2020

Vitamin D deficiency during early development can influence metabolic health

Using a zebrafish model, researchers from North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation.

29 Sep 2020

Naturally occurring enzyme holds potential as low-cost therapeutic to treat COVID-19

Researchers from UCLA and China have found that catalase, a naturally occurring enzyme, holds potential as a low-cost therapeutic drug to treat COVID-19 symptoms and suppress the replication of coronavirus inside the body.

29 Sep 2020

Computer model unravels mystery behind severe inflammation in people with COVID-19

A study from the University of Pittsburgh School of Medicine and Cedars-Sinai addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation?

29 Sep 2020

Dietary oat bran can offset radiation-induced gut inflammation, study shows

Loved or hated, the humble oat could be the new superfood for cancer patients as international research shows a diet rich in fibre could significantly reduce radiation-induced gut inflammation.

29 Sep 2020

How might India's monsoon season impact COVID-19 ?

A new study, by two Goethe University Frankfurt researchers, published on the preprint server medRxiv* in September 2020 explores the relationship between the monsoon season, the chances of exposure to ultraviolet B (UVB) radiation, and the COVID-19 mortality.

29 Sep 2020

Healthy vitamin D levels could reduce COVID-19 complications

Published in the journal PLOS ONE, the study investigates the link between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes and parameters of immune function and mortality due to COVID-19.

28 Sep 2020

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Now in new research published on the preprint server bioRxix*, a novel formulation of the drug Niclosamide (NIC) is observed to be effective against SARS-CoV-2 and MERS-CoV in mouse models; it also protects against methicillin-resistance Staphylococcus aureus pneumonia and inflammatory lung damage.

28 Sep 2020

Anti-N-protein IgG may predict severity of COVID-19

A recent study by researchers at the University of Miami, Miami VA Healthcare System and Express Gene and published on the preprint server medRxiv in September 2020 reports on the prognostic significance of the anti-N Immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Sep 2020

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

A multinational research group recently published a paper in the journal Lancet Respiratory Medicine which describes the first patient with a severe form of coronavirus disease (COVID-19) that was successfully treated with human recombinant soluble ACE2.

27 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

Molecular insights may foster effective therapies for COVID-19 patients

Viral and bacterial pathogens wield pathogenic or virulent proteins that interact with high-value targets inside human cells, attacking what is known as the host interactome. The host interactome is the network map of all the protein-protein interactions inside cells.

24 Sep 2020

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Various plants and their products are known to contain "bioactive" ingredients that can alleviate human diseases. These "phytocompounds" often contain restorative biological properties such as anti-cancerous, antioxidant, and anti-inflammatory effects.

24 Sep 2020

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Using bioinformatics approaches, researchers have identified genes and pathways shared among patients with comorbidities and having severe COVID-19. The research is published on the preprint server bioRxiv in September 2020.

23 Sep 2020

Study detects key differences in immune responses of adults and children with COVID-19

The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

22 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Scientists from the Department of Cell Biology of the University of Malaga and the Andalusian Centre for Nanomedicine and Biotechnology have made progress in finding new rapid implementation therapies to combat the COVID-19 pandemic, identifying a new drug that could prevent or mitigate the consequences derived from SARS-CoV-2 infection.

19 Sep 2020

Animal data supports efficacy of baricitinib vs SARS-COV-2

The high burden of disease caused by the COVID-19 pandemic has led to much research on effective ways to mitigate the health, social, and economic impact of the spread of the infection. A recent study published on the preprint server bioRxiv* in September 2020 reports on the characteristics of the drug baricitinib when used as monotherapy to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020