Cytokine News and Research

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First extensive review of COVID-19's effects on all affected organs outside the lungs

After only a few days caring for critically ill COVID-19 patients at the start of the outbreak in New York City, Aakriti Gupta, MD, realized that this was much more than a respiratory disease.

12 Jul 2020

COVID-19-associated stroke patients have higher risk for severe disability and death

Acute ischemic strokes (AIS) associated with COVID-19 are more severe, lead to worse functional outcomes and are associated with higher mortality , according to new research published yesterday in Stroke, a journal of the American Stroke Association, a division of the American Heart Association.

12 Jul 2020

Use of whole blood transcriptomes may improve COVID-19 diagnosis and treatment

In a new paper published on the preprint server medRxiv*, a multinational group of researchers provide the first evidence for the use of whole blood transcriptomics to distinguish coronavirus disease (COVID-19) from other infections, and also to monitor and potentially predict disease outcomes.

9 Jul 2020

Insilico Medicine, Arctoris announce technology partnership to discover new COVID-19 drugs

Insilico Medicine, a biotechnology company developing an end-to-end drug discovery pipeline utilizing next-generation artificial intelligence, today announced a technology partnership with Arctoris, the world's first fully automated drug discovery platform, offering remotely accessible, pre-optimized and fully validated R&D processes for its partners and clients globally.

9 Jul 2020

PRMT5 inhibitors can help treat advanced melanoma

Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy.

9 Jul 2020

New method helps pinpoint new potential therapeutic targets for lupus

A team of researchers from Children's Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders.

8 Jul 2020

Researchers propose novel approach to limit life-threatening complications related to COVID-19

Patients with severe COVID-19 frequently experience a life-threatening immune reaction, sometimes called a cytokine storm, which can lead to respiratory failure, organ damage and potentially death.

8 Jul 2020

Lung physiology and immune function could spare children from severe COVID-19

Differences in lung physiology and immune function in children could be why they are more often spared from severe illness associated with COVID-19 than adults, according to pediatric and adult physicians at The University of Texas Health Science Center at Houston and Baylor College of Medicine, who teamed up to investigate the disparity.

8 Jul 2020

Small molecule drugs binding Mac1 domain of SARS-CoV-2

Now, an intriguing new study out of the University of Wisconsin-Milwaukee reveals that numerous small molecule drugs like the proton pump inhibitors omeprazole and rabeprazole bind the important Mac1 domain on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.

8 Jul 2020

Research sheds light on mysterious COVID-19 related hyperinflammatory shock in children

The ongoing COVID-19 pandemic has cost hundreds of thousands of human lives, besides more than 11 million cases. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the disease was initially thought to be more severe in the elderly and those with pre-existing medical conditions. However, it started to manifest in children after the peak of the first wave.

7 Jul 2020

Research suggests protective effect of influenza vaccine against COVID-19 severity and mortality

A new study involving over 92,000 patients with COVID-19 in Brazil shows that the odds of severe disease, ventilatory support requirement, and death are reduced with a recent trivalent flu vaccine. This seems to indicate that these vaccines should be used as widely as possible to reduce the risk of severe COVID-19, especially among high-risk groups. The study is published on the preprint server medRxiv* in June 2020.

5 Jul 2020

Researchers find possible cause for SARS-CoV-2 reactive T cells in uninfected individuals

The current pandemic of COVID-19 is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV) -2, leading to severe pneumonia, acute respiratory distress syndrome, and death in a sizable minority of cases. However, the most significant number are asymptomatic or have only mild infection from which they rapidly recover.

2 Jul 2020

New drug discovery shows promise in fighting acute respiratory illnesses

A collaboration between the University of Toronto's Faculty of Dentistry and the National Jewish Health in Denver -- the top-ranked respiratory research hospital in the U.S. -- has yielded a new drug discovery that could be useful to combat inflammation of all varieties and shows promise in fighting acute respiratory illnesses such as COVID-19.

2 Jul 2020

Oxidized charcoal nanoparticles can help treat COVID-19 patients

Artificial enzymes made of treated charcoal could have the power to curtail damaging levels of superoxides, radical oxygen ions that are toxic at high concentrations.

2 Jul 2020

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

A new study published on the preprint server bioRxiv in June 2020 shows that a candidate spike protein vaccine can induce neutralizing antibodies, antiviral T cell responses, and protection against infection.

2 Jul 2020

New NCCN guidelines explain how to recognize and manage immunotherapy-related side effects

The National Comprehensive Cancer Network today announced the completion of the new NCCN Guidelines for Patients®: Immunotherapy Side Effects series, with the publication of a book focused on chimeric antigen receptor (CAR) T-cell therapy. This closely follows the publication of a separate book on immune checkpoint inhibitors, both created with support from the NCCN Foundation®.

1 Jul 2020

BMI should be assessed in management of COVID-19 patients

A new study published on the preprint server medRxiv* in June 2020 reports that obesity is a risk factor of composite poor outcome of COVID-19 disease. On the other hand, COVID-19 patients with 'composite poor outcome' have higher BMI. Therefore, BMI should be assessed in the management of COVID-19 patients, and special attention should be given to patients with obesity.

1 Jul 2020

Cytokine News and Research

First extensive review of COVID-19's effects on all affected organs outside the lungs

COVID-19-associated stroke patients have higher risk for severe disability and death

Use of whole blood transcriptomes may improve COVID-19 diagnosis and treatment

Insilico Medicine, Arctoris announce technology partnership to discover new COVID-19 drugs

PRMT5 inhibitors can help treat advanced melanoma

New method helps pinpoint new potential therapeutic targets for lupus

Researchers propose novel approach to limit life-threatening complications related to COVID-19

Lung physiology and immune function could spare children from severe COVID-19

Small molecule drugs binding Mac1 domain of SARS-CoV-2

Research sheds light on mysterious COVID-19 related hyperinflammatory shock in children

Research suggests protective effect of influenza vaccine against COVID-19 severity and mortality

Researchers find possible cause for SARS-CoV-2 reactive T cells in uninfected individuals

New drug discovery shows promise in fighting acute respiratory illnesses

Oxidized charcoal nanoparticles can help treat COVID-19 patients

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

New NCCN guidelines explain how to recognize and manage immunotherapy-related side effects

BMI should be assessed in management of COVID-19 patients

COVID-19 patients' blood can help identify people at greatest risk of severe illness

Salk Institute expands research to find treatments and cures for COVID-19

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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