Cytomegalovirus News and Research

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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.

Further Reading

New genomic tools provide better understanding of the human immune system

New genomic tools provide better understanding of the human immune system

New vaccine approach offers effective protection against tuberculosis

New vaccine approach offers effective protection against tuberculosis

Research could contribute to development of therapeutic drug and vaccine against malaria

Research could contribute to development of therapeutic drug and vaccine against malaria

Anti-aging protein could be used as target for rejuvenating cells in the immune system

Anti-aging protein could be used as target for rejuvenating cells in the immune system

Researchers to test use of ‘viral specific’ T-cells to target toxic viruses in children

Researchers to test use of ‘viral specific’ T-cells to target toxic viruses in children

Using biologics during pregnancy may not raise infant's risk for opportunistic infections

Using biologics during pregnancy may not raise infant's risk for opportunistic infections

Study provides rare glimpse into genetic transmission of herpes simplex virus from father to son

Study provides rare glimpse into genetic transmission of herpes simplex virus from father to son

New study explores how herpes simplex virus may change during familial transmission

New study explores how herpes simplex virus may change during familial transmission

Researchers create chimera virus that allows study of molecules to treat cancers

Researchers create chimera virus that allows study of molecules to treat cancers

ESCMID conference brings together renowned experts to address most pressing questions on vaccines

ESCMID conference brings together renowned experts to address most pressing questions on vaccines

Clinical trial shows safety, effectiveness of pre-prepared cells to treat drug-resistant viral infections

Clinical trial shows safety, effectiveness of pre-prepared cells to treat drug-resistant viral infections

Binding Site launches new antigens and antibodies for infectious/contagious diseases

Binding Site launches new antigens and antibodies for infectious/contagious diseases

Researchers identify issues with current maternal CMV screening methods

Researchers identify issues with current maternal CMV screening methods

Novel vaccine approach appears to protect fetus from CMV infection, animal study shows

Novel vaccine approach appears to protect fetus from CMV infection, animal study shows

UCLA-led study reveals possibility of CMV and HIV transmission from mothers to infants

UCLA-led study reveals possibility of CMV and HIV transmission from mothers to infants

Scientists develop new algorithm to decipher how immune system recognizes and binds antigens

Scientists develop new algorithm to decipher how immune system recognizes and binds antigens

Study provides insights into how HCMV infection causes birth defects

Study provides insights into how HCMV infection causes birth defects

Research findings identify protein as potential new drug target for HCMV infections

Research findings identify protein as potential new drug target for HCMV infections

New model may provide vital insights into life-saving treatment for CMV infection

New model may provide vital insights into life-saving treatment for CMV infection

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

Vaccine-chemotherapy combination may improve survival for glioblastoma patients