Cytotoxicity News and Research

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Comprehensive review of clioquinol drug gives valuable insights

CQ is an old drug that was commonly used to treat fungal/protozoal infections of the gastrointestinal tract. Patients in Japan taking it developed subacute myelo-optic neuropathy which resulted in CQ being discontinued for oral use. Recently, extensive research has been done in regards to CQ's use for cancer treatment.

21 May 2020

Continuously active antiviral coating may reduce the spread of COVID-19

Surfaces coated with a quaternary ammonium polymer have remarkable antiviral properties. They may even be capable of reducing the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in areas with high risk for contamination, such as indoor environments or public places. University of Arizona researchers explain the antiviral potential of these in a new study published on the preprint server medRxiv.

14 May 2020

Scientists discover a new way for T cells to attack diseased cells

Scientists at the Kennedy Institute of Rheumatology in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences have discovered a new way for T cells to attack cells infected by viruses or deranged by cancer.

12 May 2020

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

Cat coronavirus drug shows promise for treatment of COVID-19

“They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals (cats),” writes the team. “The work here lays the framework for their use in human trials for the treatment of COVID-19.”

5 May 2020

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

4 May 2020

Kurome secures license to develop novel therapies for chemo-resistant cancer

Seed investor CincyTech announced the formation of Kurome Therapeutics ("Kurome"), a preclinical stage company developing novel therapies targeting cancer cells' adaptive resistance mechanisms beginning with hematopoietic, or blood cell, cancers.

29 Apr 2020

How toxic are chloroquine and hydroxychloroquine to cells?

The spread of the pandemic disease COVID-19 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has now reached almost every country of the world, with over 3.11 million cases and over 217,000 deaths as of April 29, 2020.

29 Apr 2020

Study highlights triptolide as valuable therapeutic approach for IDH1-mutated glioma

Findings of a new study led by Prof. XU Guowang from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences and Prof. YANG Chunzhang from the National Cancer Institute shed light on the selective therapeutics for IDH1-mutated glioma by targeting glutathione synthesis pathway.

13 Apr 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

SABIC introduces new LNP ELCRES CRX PC copolymers at MD&M West 2020

The use of highly aggressive chemical disinfectants is a common approach to preventing hospital-acquired infections in hospitals and clinics. However, these disinfectants can produce side effects in the polymers used in medical device components and equipment housings.

From SABIC 13 Feb 2020

Novel inhibitor to fight metastatic prostate cancer shows promise

When prostate cancer spreads it is often a deadly disease, but now a Stony Brook University-led research team believes a new approach that inhibits a specific fatty acid binding protein (FABP) may be the key to halting disease progression.

30 Jan 2020

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

Innovative compound kills cancer cells, minimizes damage to normal tissues

Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient's blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be killed as "collateral damage", leading to undesired side effects.

3 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A US study on DNA-based and protein HIV vaccines has shown that an antibody and cellular immune response occurs within six weeks.

2 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A new study using DNA-based and protein HIV vaccines in various combinations shows that antibody and cellular immune response occurs within 6 weeks from the date of vaccination, and the combination must be administered together for the most rapid protection. This will enable more large-scale testing of the vaccine for effectiveness. About 40 million people today have HIV infections, and 1.2 million deaths a year are related to this infection.

1 Oct 2019

What are the health effects of vaping?

Vaping and its effects have gained immense popularity over the past weeks due to the emergence of a mysterious and severe lung disease. Electronic cigarettes or e-cigarettes, also called vapes, electronic nicotine delivery systems, vape pens, or mods, have become very popular across the globe, especially among teens.

1 Oct 2019