DNA Damage News and Research

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Human gingival epithelial cells become damaged by cannabis smoke condensate

In a new study, scientists evaluated the effect of cannabis smoke condensate (CSC) on the gingival epithelial cells.

5 Jul 2022

Study uncovers new gene that increases Alzheimer's disease risk in women

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer's; the most well-known of these for people over the age of 65 is the APOE ε4 allele.

30 Jun 2022

Researchers improve the ability of a protein to repair oxidative DNA damage

Researchers at Karolinska Institutet and SciLifeLab in Sweden describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function.

23 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

Social stress factors have a direct impact on cellular mechanisms that drive deadly breast cancer

Chronically stressful conditions of daily life such as racism, pollution and poverty have a direct impact on the cellular mechanisms that drive lethal, invasive forms of breast cancer, according to a study led by Duke Cancer Institute researchers.

13 Jun 2022

Scientists provide crucial insights into the roles of inflammation and oxidative stress in certain cancers

Rampant inflammation has long been linked to cancer but exactly how it pushes healthy cells to transform into malignant ones has remained a mystery.

7 Jun 2022

Penn biologists show evidence of a two-sided genomic arms race involving repetitive DNA

Biological arms races are commonplace in nature. Cheetahs, for example, have evolved a sleek body form that lends itself to rapid running, enabling them to feast upon similarly speedy gazelles, the fastest of which may evade predation.

27 May 2022

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

‘Sting’ protein’s response to clean up damaged brain cells may accelerate Parkinson’s disease progression

In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's disease.

19 May 2022

Intestinal microbiome may contribute to the pathogenesis of MSI colon cancers, study suggests

Investigators from Rutgers Cancer Institute of New Jersey, New Jersey's only National Cancer Institute- Designated Comprehensive Cancer Center, led a collaborative study to examine the patterns of druggable oncogenic fusions in colon cancer specimens including microsatellite-stable and unstable (MSI) tumors.

19 May 2022

Mathematical theory describes the process of checkpoint override by cells

Cells go through a life cycle that includes growing to the right size, being equipped to perform its functions, and finally dividing into two new cells.

12 May 2022

Research describes how DNA damage can affect neural health and function

A new research paper in the journal EMBO Reports describes how DNA damage can affect neural health and function.

12 May 2022

Exploring the impact of bacterial infection and gut microbiome on colorectal cancer development

Intestinal micro-biodiversity is important for maintaining colorectal and general health. Imbalance in this microenvironment can result in chronic infections, even cancer.

10 May 2022

Lung cancer risk increases with emphysema severity, study reveals

CT-detected emphysema is linked to a higher risk of lung cancer, a risk that increases with emphysema severity, according to a new study published in the journal Radiology.

3 May 2022

Misexpression of non-cardiac genes may lead to congenital heart disease

Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

27 Apr 2022

Discovery about human cells’ stress response could deepen the understanding of various cancers

The communications line between two critical parts of a human cell could be the key to cell survival under stress - a discovery that could deepen our understanding of various cancers, according to new research from the University of Surrey.

26 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons -; more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Role of cGAS-STING in SARS-CoV-2 infection

A new study analyzes the activation of cGAS and STING can induce a type I IFN response due to SARS-CoV-2 infection.

15 Apr 2022

Regulation of alternative splicing goes haywire in cells of a newly formed embryo

Alternative splicing is a fundamental biological process that allows cells to make many different types of mRNAs and proteins from a limited number of genes. For many animals, including humans, it is a feature that is essential for the development of complex cells such as muscles or neurons.

13 Apr 2022

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have developed a new bioinformatics platform that predicts optimal treatment combinations for a given group of patients based on co-occurring tumor alterations.

12 Apr 2022