DNA Damage News and Research

RSS

Discovery of 'marker' molecule offers hope for liver cancer test

Cancer Research UK scientists have discovered a 'marker' molecule which could pinpoint when liver cells start to become cancerous, reveals research published in Science*.

9 Aug 2009

Genetic profiling of tumors could have 'immediate impact' on treating cancer

New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.

6 Aug 2009

Protein DNA repair complex key to avoiding DNA repair mistakes

As the body creates antibodies to fight invaders, a three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly, University of Michigan research shows.

5 Aug 2009

New clues about the roots of neurological disease

Switching off a key DNA repair system in the developing nervous system is linked to smaller brain size as well as problems in brain structures vital to movement, memory and emotion, according to new research led by St. Jude Children's Research Hospital scientists.

27 Jul 2009

New discovery on DNA repair mechanism

Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. Their findings could lead to ways of enhancing chemotherapy drugs that destroy cancer cells by damaging their DNA.

17 Jul 2009

Surprising new insights into the repair strategies of DNA

A microscopic single-celled organism, adapted to survive in some of the harshest environments on earth, could help scientists gain a better understanding of how cancer cells behave.

15 Jul 2009

One secret to how tuberculosis resists the host immune system

Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. Now, a report in the July 10 issue of the journal Cell, a Cell Press publication, offers new insight into the bugs' talent for meager living.

9 Jul 2009

Daily sex good for sperm!

An Australian scientist says a daily dose of sex is the best thing for producing healthy sperm and daily ejaculation works just as well.

5 Jul 2009

Frequent sex improves sperm quality

Daily sex (or ejaculating daily) for seven days improves men's sperm quality by reducing the amount of DNA damage, according to an Australian study presented today (Tuesday) to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.

30 Jun 2009

Don't stress when the going gets tough - you'll go gray!

A study by Japanese researchers has revealed that a certain kind of stress damages the hair - they say "genotoxic stress" damages DNA by depleting the melanocyte stem cells (MSCs) within hair follicles that are responsible for making the pigment-producing cells.

14 Jun 2009

Genotoxic stress makes your hair go gray

Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the June 12 issue of Cell, a Cell Press publication.

12 Jun 2009

Yeast 'DNA damage sensor' provides chemotherapy resistance clue

Cancer Research UK scientists have been part of an international collaboration that has revealed the structure of a protein found in simple yeast cells and shown how it flags up damaged DNA for repair. The results of their study are published in Nature*. The finding may provide clues as to how some cancer cells become resistant to certain chemotherapy drugs.

11 Jun 2009

Gene activity reveals dynamic stroma microenvironment in prostate cancer

As stroma - the supportive framework of the prostate gland - react to prostate cancer, changes in the expression of genes occur that induce the formation of new structures such as blood vessels, nerves and parts of nerves, said researchers at Baylor College of Medicine in a report that appears in the current issue of the journal Clinical Cancer Research.

9 Jun 2009

Research links intestinal inflammation with systemic chromosome damage

UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders, some of which increase risk for several types of cancer.

1 Jun 2009

New findings on how lithium may help radiation target cancer

Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments.

4 May 2009

DNA protecting protein helps cancer drug to kill cells

Some DNA repair enzymes can become double-edged swords - If they work too slowly, they can block necessary cell maintenance and contribute to cell death.

30 Apr 2009

New study overturns orthodoxy on how macrophages kill bacteria

For decades, microbiologists assumed that macrophages, immune cells that can engulf and poison bacteria and other pathogens, killed microbes by damaging their DNA.

27 Apr 2009

Research shows how p53 mutations link to high-grade breast cancer, poor outcomes

In what is believed to be the largest study of its kind in the US, researchers have found that almost 26 percent of women studied who have breast cancer have mutations in a gene important in controlling cell growth and death, and that patients with mutations in this gene - known as p53 - had poorer outcomes including a significantly increased risk of death from the cancer.

20 Apr 2009

New nucleotide could revolutionize epigenetics

Anyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine - the A,T,G and C that make up the DNA code.

16 Apr 2009

Researchers model 3D structures of proteins that control human clock

In an Early Edition issue of The Proceedings of the National Academy of Sciences (PNAS) on April 9, 2009, the researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surprisingly similar to two cryptochrome proteins that control the "master clock" in humans and other mammals.

12 Apr 2009