Developmental Biology News and Research

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Human embryonic stem cell, iPS-derived progeny are similar and developmentally immature

Stem cell researchers at UCLA have discovered that three types of cells derived from human embryonic stem cells and induced pluripotent stem cells are similar to each other, but are much more developmentally immature than previously thought when compared to those same cell types taken directly from human tissue.

18 Aug 2011

Semaphorin-PlexinD1 signaling pathway shows promise as therapeutic target for cancer treatment

In a new study published in the August 16th issue of Developmental Cell, researchers at NYU Langone Medical Center identified a molecular mechanism that guarantees that new blood vessels form in the right place and with the proper abundance.

17 Aug 2011

New strategies for successful donor adult stem cell transplants in blood cancer patients

Findings by UT Southwestern Medical Center researchers may suggest new strategies for successful donor adult stem cell transplants in patients with blood cancers such as leukemia, lymphoma and myeloma.

5 Aug 2011

Key protein discoveries could lead to new lung repair therapies for children, adults

A team at The Saban Research Institute of Children's Hospital Los Angeles has made crucial discoveries about the role of key proteins in wound healing in the tiny air sacs in the lungs known as "alveoli" that could lead to new therapies for children and adults.

5 Aug 2011

BD Biosciences, Fluidigm to co-host public seminars on isolation and analysis of single cells

Fluidigm Corporation announced today a collaboration with BD Biosciences, a segment of BD, to co-host a public seminar series on the isolation and analysis of single cells. Entitled A Powerful Technique for Single-Cell Analysis, the public seminar series will showcase cell isolation using the BD FACSAria III Cell Sorter and analysis using the Fluidigm BioMark HD System.

From BD (Becton, Dickinson and Company) 5 Aug 2011

Bear bile compound may help treat heart attack: Study

The compound, ursodeoxycholic acid (UDCA), is already used to lower cholesterol and help dissolve gallstones, and it's a key ingredient in many traditional Chinese medicines, which use bear bile. According to the latest research from Imperial College London it might also be able to treat abnormal heart rhythm, or arrhythmia, in fetuses and heart attack victims.

3 Aug 2011

Ursodeoxycholic acid could help prevent disturbances in heart's normal rhythm

A synthesised compound which is also found in bear bile could help prevent disturbances in the heart's normal rhythm, according to research published today in the journal Hepatology by a team from Imperial College London.

2 Aug 2011

First genome-wide mapping of DNA modification in embryonic stem cells

Stem cell researchers at UCLA have generated the first genome-wide mapping of a DNA modification called 5-hydroxymethylcytosine (5hmC) in embryonic stem cells, and discovered that it is predominantly found in genes that are turned on, or active.

22 Jul 2011

Loss of critical male development gene causes male cells to become female

University of Minnesota Medical School and College of Biological Sciences researchers have made a key discovery showing that male sex must be maintained throughout life.

21 Jul 2011

Scientists find way to make copper-catalyzed click chemistry biocompatible

Biomolecular imaging can reveal a great deal of information about the inner workings of cells and one of the most attractive targets for imaging are glycans - sugars that are ubiquitous to living organisms and abundant on cell surfaces. Imaging a glycan requires that it be tagged or labeled. One of the best techniques for doing this is a technique called click chemistry.

19 Jul 2011

Researchers identify cellular origin of malignant glioma

Using a mouse genetic system co-developed by researchers at the University of Oregon and Stanford University, a research team led by UO biologist Hui Zong has isolated the cellular origin for malignant glioma, a deadly human brain cancer.

8 Jul 2011

New technique explores how cells react to rapidly changing patterns of chemoattractants

Many cell types in higher organisms are capable of implementing directed motion in response to the presence of certain chemical attractants in their vicinity. A team led by Dr. Doris Heinrich of the Faculty of Physics and the Center for NanoScience (CeNS) at Ludwig-Maximilians-Universit-t (LMU) in Munich has developed a novel technique to expose an ensemble of living cells to rapidly varying concentrations of chemoattractants.

6 Jul 2011

Researchers create tissue-engineered small intestine in mice

Researchers at The Saban Research Institute of Children's Hospital Los Angeles have successfully created a tissue-engineered small intestine in mice that replicates the intestinal structures of natural intestine-a necessary first step toward someday applying this regenerative medicine technique to humans.

6 Jul 2011

Researchers discover crucial role of miR-206 in skeletal muscle development

Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development.

5 Jul 2011

Autism Speaks Weatherstone fellows publish new mouse model findings in Cell journal

Autism Speaks Weatherstone Pre-Doctoral Fellows M. Ali Bangash, a 2009 fellow, and Mehreen Kouser, a 2010 fellow, recently published new findings in the journal Cell that shed light on the biology of autism.

1 Jul 2011

Scientists discover origin of Barrett's esophagus

Dr Frank McKeon, Senior Group Leader of the Stem Cell and Developmental Biology at A*STAR's Genome Institute of Singapore, and Principal Investigator Dr Wa Xian at A*STAR's Institute of Medical Biology, together with their counterparts from the Harvard Medical School, the Brigham and Women's Hospital in Boston, and the National University of Singapore, have made the striking finding that Barrett's esophagus work, published online in the journal Cell on 24 June 2011, is essential to developing therapeutics for esophageal cancer.

28 Jun 2011

Scientists find neuronal cells die in Alzheimer's disease

In what they are calling a new direction in the study of Alzheimer's disease, UC Santa Barbara scientists have made an important finding about what happens to brain cells that are destroyed in Alzheimer's disease and related dementias.

8 Jun 2011

New discoveries about role of blood vessels in early lung development

A research team at The Saban Research Institute of Children's Hospital Los Angeles has made critical new discoveries about the role of blood vessels in guiding early lung development, especially in the essential, highly reproducible branching pattern of lung airways.

4 Jun 2011

New research contributes to basic biological understanding of how retinas develop

New research at UC Santa Barbara is contributing to the basic biological understanding of how retinas develop. The study is part of the campus's expanding vision research.

21 May 2011

GIS discovery could help generate stem cells more efficiently for biomedical applications

A team of scientists from Genome Institute of Singapore (GIS) of the Agency for Science, Technology and Research (A*STAR) have shown how proteins involved in controlling genes work together to carry out their functions in stem cells and demonstrated for the very first time, how they can change interaction partners to make other types of cells.

20 May 2011