Diabetes Mellitus News and Research

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Diabetes mellitus is a severe and debilitating chronic disease that develops in nearly 5 percent of the world’s population. People with this disease have a shortage of insulin or a reduced ability to use insulin, the hormone regulating blood glucose levels, which is normally produced by the pancreas. In the United States alone, an estimated 18 million people have diabetes, and each year about 1 million Americans are diagnosed with the disease. It is the sixth leading cause of death in the US and is responsible for over 200,000 deaths a year. Insulin-dependent (type I) diabetes accounts for around 10% of diabetics. For those patients, suffering from an inability of their pancreas to produce insulin, the only practical treatment possible is regular insulin replacement by multiple daily injections. Transplantation of a pancreas or pancreatic tissue would be beneficial to millions of such patients in that it would restore their normal ability to produce self insulin. Transplantation of human pancreas or pancreatic islets is a practiced and time-honored such therapeutic approach, but is extremely limited by the severe shortage of human donor organs. Tissera's R&D efforts in this domain are directed towards the development of a universally available and reliable source of animal fetal donor pancreatic precursor tissue, suitable for transplantation and eventual normal structural and functional growth in human diabetics.

Mutations in newly discovered gene, NPHP5 cause Senior-Loken syndrome

Scientists at the University of Michigan Medical School have discovered a gene called NPHP5 and found mutations in this gene that cause a rare genetic disease called Senior-Loken syndrome. Children with this syndrome develop a type of cystic kidney disease called nephronophthisis, as well as a form of blindness called retinitis pigmentosa.

3 Mar 2005

Kidney dysfunction in HIV patients can be detected earlier

Tracking the subtle kidney damage that can lead to chronic kidney disease in HIV patients is increasingly important as people survive longer and may have an increased risk of renal dysfunction as a result of their disease, therapy-related damage, or co-morbid conditions such as diabetes mellitus and hypertension.

28 Feb 2005

Cell phones useful and feasible for visualizing leg wounds

Use of cell phones to send images via e-mail to consulting physicians at remote locations appears to be a feasible approach for visualization of chronic leg ulcerations, according to an article in the current issue of Archives of Dermatology.

21 Feb 2005

Olmesartan improves blood supply to kidneys

How do medications that block the renin-angiotensin system (RAS blockers) work to protect against kidney disease in people with diabetes? At least partly by improving the blood supply to the kidneys, suggests a study in the April Journal of the American Society of Nephrology.

17 Feb 2005

Soy may reduce risk of cardiovascular disease

Every 34 seconds, an American man or woman dies of cardiovascular disease. Now, research suggests that a diet rich in soybean oil can help. Two new studies shed light on the power of alpha-linolenic acid (ALA) to reduce heart disease risk. Soybean oil provides an excellent source of ALA, as do leafy greens, some nuts and flax.

12 Jan 2005

Elevated glucose levels and diabetes associated with a greater risk for cancer

New research involving more than one million people indicates that having high fasting serum glucose levels and diabetes are risk factors for several major cancers, according to a study in the January 12 issue of JAMA.

12 Jan 2005

Sticking to one diet plan key to losing weight

A comparison of four popular diet plans finds that the key to losing weight may not be which diet plan a person picks, but sticking with the plan that is chosen, according to a study in the January 5 issue of JAMA.

5 Jan 2005

Good oil in walnuts helps diabetes patients

People developing Type 2 Diabetes know they need more than an apple a day to keep the doctor away. But a handful of walnuts might help.

4 Dec 2004

Elevated BMI may not increase risk of death among men with heart attack or stroke

BMI, or body mass index, is considered an indicator of both mortality and heart attack risk among middle-aged and older men free of major diseases. However, the impact of BMI on mortality in men who have already had a heart attack or stroke has not been clearly established.

29 Nov 2004

Patients taking the lipid-lowering medications have a relatively low risk of developing rhabdomyolysis

Patients taking the lipid-lowering medications atorvastatin, pravastatin, and simvastatin to reduce cholesterol levels, have a relatively low risk of developing rhabdomyolysis, (a disorder that causes the breakdown of muscle), according to a new study in the December 1 issue of JAMA.

23 Nov 2004

A new magnetic navigation system shows promise for use during percutaneous coronary interventions

The magnetic-assisted intervention is being introduced in the United States and Europe, with fewer than 15 systems installed at institutions worldwide. Developed by Stereotaxis, Inc., a St. Louis firm, the system was approved by the U.S. Food and Drug Administration in 2003.

9 Nov 2004

New beta blocker may help diabetic patients with high blood pressure

A medication that is commonly used to control high blood pressure does not raise blood sugar levels in diabetics who also have high blood pressure, according to researchers from Rush University Medical Center.

9 Nov 2004

Patients with type 2 diabetes and hypertension who kept their blood pressure very tightly controlled had fewer eye disorders caused by their diabetes

According to the article, type 2 diabetes and hypertension are often associated. At age 40, approximately 32 percent of patients with type 2 diabetes are also hypertensive, and that proportion increases to 47 percent by age 60, the article states.

8 Nov 2004

Obese patients have higher health care costs

Compared to nonobese persons, obese patients had higher average health care costs over a one-year period, according to an article in the October 25 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

25 Oct 2004

Studies examine risk factors and potential consequences associated with prehypertension

A substantial proportion of Americans have prehypertension (blood pressure above optimal levels, but not clinical hypertension) which is associated with an increased prevalence of other risk factors for heart disease and stroke and is also associated with potential increased risk for hospitalization and death

25 Oct 2004

Strong relationship between kids academic achievement and fitness

The health benefits of exercise – across the lifespan – have been well documented. More recently, scientists have begun to demonstrate that exercise also may improve cognitive functioning in older adults.

19 Oct 2004

Weight loss surgery reduces components of metabolic syndrome in obese patients

Obese patients who underwent surgical treatment for weight loss had significant reductions in the components of the metabolic syndrome one year after surgery, according to an article in the October issue of The Archives of Surgery.

18 Oct 2004

People with diabetes mellitus have three to four times the risk of developing liver cancer

People with diabetes mellitus have three to four times the risk of developing liver cancer, and more than twice the risk of developing pancreatic cancer than non-diabetic individuals, according to research presented at the Third Annual Frontiers in Cancer Prevention Research Meeting in Seattle.

18 Oct 2004

Lifestyle factors that increase the risk of heart disease in adults begin to take hold in childhood

In one study, Boston researchers found that about two-thirds of 1,960 adolescents studied had at least one risk factor for heart disease, and almost 10 percent had a cluster of factors known as metabolic syndrome.

11 Oct 2004

Treatment of obesity reduces the onset of lifestyle diseases such as hypertension, high cholesterol levels, diabetes mellitus, and even erectile dysfunction

And according to the University of Adelaide’s Associate Professor Gary Wittert, who is championing The Florey Adelaide Male Ageing Study, there is a compelling argument for an aggressive intervention program given the high prevalence of obesity and the relationship to the aforementioned health problems.