Disease Modeling News and Research

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ORIG3N, LabCorp form strategic partnership

ORIG3N, Inc., a pioneer in regenerative medicine and provider of induced pluripotent stem cell (iPSC) storage, called LifeCapsule, today announced a strategic collaboration with Laboratory Corporation of America Holdings.

19 May 2015

MDC scientists find solution to increase efficiency of precise genetic modifications

CRISPR-Cas9 is a powerful new tool for editing the genome. For researchers around the world, the CRISPR-Cas9 technique is an exciting innovation because it is faster and cheaper than previous methods. Now, using a molecular trick, Dr. Van Trung Chu and Professor Klaus Rajewsky of the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Ralf Kühn, MDC and Berlin Institute of Health, have found a solution to considerably increase the efficiency of precise genetic modifications by up to eightfold.

30 Mar 2015

UCLA researchers develop method that defines unique stages of reprogramming skin cells

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first-of-its-kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

7 Jan 2015

Human stem cells made from adult donor cells remember their origin, say McMaster scientists

Scientists at McMaster University have discovered that human stem cells made from adult donor cells "remember" where they came from and that's what they prefer to become again.

3 Dec 2014

Research on zebrafish helps identify cause of unknown genetic disorder

Research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles, scientists report in an article published October 14 in the journal GENETICS.

16 Oct 2014

Researchers develop new lung-on-chip model for laboratory studies of respiratory challenges

Researchers at RTI International, in collaboration with the University of North Carolina at Chapel Hill, have developed a new lung-on-chip microdevice for laboratory studies of respiratory challenges and therapeutics. The microdevice includes multiple vertically stacked cellular layers that mimic the structure of the airway tissue.

15 Aug 2014

Scientists one step closer to creating viable cell replacement therapy for multiple sclerosis patients

Scientists at The New York Stem Cell Foundation Research Institute are one step closer to creating a viable cell replacement therapy for multiple sclerosis from a patient's own cells.

25 Jul 2014

Researchers find potential way to ease physical damage of numerous genetic disorders

Duke Medicine researchers studying tiny, antennae-like structures called cilia have found a potential way to ease some of the physical damage of numerous genetic disorders that result when these essential cellular components are defective.

2 Apr 2014

NYSCF partners with NIH to generate stem cell for treating rare diseases

In what is anticipated to be a major step forward for rare disease research, The New York Stem Cell Foundation (NYSCF) Research Institute is partnering with the National Institutes of Health (NIH) Undiagnosed Disease Program (UDP).

22 Nov 2013

Scientists at Salk Institute develop novel platform to study kidney diseases

Diseases affecting the kidneys represent a major and unsolved health issue worldwide. The kidneys rarely recover function once they are damaged by disease, highlighting the urgent need for better knowledge of kidney development and physiology.

19 Nov 2013

Researchers generate three-dimensional kidney structures from human stem cells

18 Nov 2013

Study could enhance process of reprogramming adult cells into embryonic-like stem cells

Bioengineers at the University of California, Berkeley, have shown that physical cues can replace certain chemicals when nudging mature cells back to a pluripotent stage, capable of becoming any cell type in the body.

23 Oct 2013

Research: Zebrafish exhibits same developmental issues as humans

Duke researchers have connected very rare and precise duplications and deletions in the human genome to their complex disease consequences by duplicating them in zebrafish.

18 Oct 2013

Scientists uncover new approach to develop induced pluripotent stem cells for in vivo disease modeling

In a paper in Cell Stem Cell, a team led by researchers in the Boston Children's Hospital's Stem Cell Transplantation Program reports a new approach for turning induced pluripotent stem cells (iPSCs) into hematopoietic stem and progenitor cells for in vivo disease modeling.

4 Oct 2013

Researchers find way to differentiate iPSCs into mature human neurons in the brain

Difficult-to-study diseases such as Alzheimer's, schizophrenia, and autism now can be probed more safely and effectively thanks to an innovative new method for obtaining mature brain cells called neurons from reprogrammed skin cells. According to Gong Chen, the Verne M. Willaman Chair in Life Sciences and professor of biology at Penn State University and the leader of the research team, "the most exciting part of this research is that it offers the promise of direct disease modeling, allowing for the creation, in a Petri dish, of mature human neurons that behave a lot like neurons that grow naturally in the human brain."

10 Jun 2013

Researchers identify genetic mutations that appear to underlie rare syndrome

Researchers from Massachusetts General Hospital and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia - a lack of muscle coordination - and dementia.

9 May 2013

Research reveals method to produce retinal cells from regenerative human stem cells

Research led by a biology professor in the School of Science at Indiana University-Purdue University Indianapolis has uncovered a method to produce retinal cells from regenerative human stem cells without the use of animal products, proteins or other foreign substances, which historically have limited the application of stem cells to treat disease and other human developmental disorders.

20 Mar 2013

NYSCF conference to discuss latest advances in stem cell research

Leaders in translational stem cell research from across the country and around the world will present findings on how advances in stem cell science lead to better treatments and cures to disease and injury at The New York Stem Cell Foundation's Seventh Annual Translational Stem Cell Research Conference, held at The Rockefeller University in Manhattan on October 10-11.

11 Oct 2012

Massachusetts Institute of Technology to honor IHME's health measurement expert

For the first time, a prestigious technical innovation honor from the Massachusetts Institute of Technology (MIT) will go to an expert in health measurement: Abraham Flaxman, an Assistant Professor of Global Health at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington (UW).

22 Aug 2012

Fate Therapeutics, BD Biosciences introduce first collaborative iPSC-related product

Fate Therapeutics, Inc. in collaboration with BD Biosciences, a segment of BD (Becton, Dickinson and Company), today announced the introduction of the first induced pluripotent stem cell (iPSC)-related product resulting from the collaboration between the two companies.

From BD (Becton, Dickinson and Company) 11 Jun 2012