Disease Modeling News and Research

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Stem-cell-derived brain cells hold promise for Alzheimer's, Parkinson's research

Researchers at the University of Wisconsin–Madison have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer's and Parkinson's diseases and used the discovery to grow the neurons from stem cells for the first time.

17 Nov 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

13 Nov 2023

U-M receives CDC grant to establish new center to improve public health response to disease outbreaks

The University of Michigan is among 13 institutions that will receive funding from the Centers for Disease Control and Prevention to be part of a national network of centers focused on predicting and responding to future disease outbreaks.

20 Sep 2023

Mount Sinai researchers identify the structure of a special red blood cell transporter

Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.

8 Sep 2023

New research sheds light on role of KRAS mutations in pancreatic cancer

Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer.

24 Aug 2023

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Penn state researchers receive $2 million NIH grant to develop new bioprinting technology

Developing technology to quickly and efficiently bioprint human tissues at scale is the goal of a new project led by Penn State researchers.

21 Jul 2023

Scarring to the collagen framework causes dysfunction in Duchenne muscular dystrophy

Muscles that ache after a hard workout usually don't hurt for long, thanks to stem cells that rush to the injured site along "collagen highways" within the muscle and repair the damaged tissue.

11 May 2023

New small-molecule drugs show potential clinical utility in treating world’s leading causes of blindness

In a University of California, Irvine-led study, researchers have discovered small-molecule drugs with potential clinical utility in the treatment of age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP).

9 May 2023

Mount Sinai announces creation of the Institute for Regenerative Medicine

Regenerative medicine-; the process of replacing, engineering or regenerating human cells, tissues or organs-; holds exciting potential for the field of health care.

24 Apr 2023

Bioprinting combined with AI allows to obtain high-quality homogenized in vitro models

In the process of organoid manufacturing, bioprinting technology can not only facilitate the creation and maintenance of complex biological 3D shapes and structures, but also allow for standardization and quality control during production.

11 Apr 2023

POSTECH team engineers an artificial kidney for early detection of adverse drug reactions

The kidney plays a vital role in maintaining homeostasis within the body by eliminating toxic and superfluous substances in the bloodstream, including waste generated during metabolic processes, through urine.

31 Mar 2023

The impact of climate change on West Nile virus transmission

In a recent study published in One Health, researchers projected the West Nile virus (WNV) spread in the context of climate change.

24 Feb 2023

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

22 Feb 2023

Researchers develop a cell line to address the challenges facing cellular modeling of disease

Bill Skarnes and team established and characterized a stable iPSC line, KOLF2.1J, to act as a high-quality baseline platform for modeling human disease.

3 Feb 2023

CuSTOM; Creating a healthier society by accelerating the translation of organoid technology

In this interview, we speak to Magdalena Kasendra at the CuSTOM Accelerator, about the organoid technology and how it has the power the revolutionize healthcare.

From Society for Laboratory Automation and Screening (SLAS) 1 Feb 2023

Borrowing from weather and climate science models can help us prepare for future pandemics

A new study determines how insights from the climate and weather research field can improve the forecasting of pandemics.

22 Jan 2023

Launch of FAU Stiles-Nicholson Brain Institute heralds a new era in neuroscience research, education

Florida Atlantic University celebrated the opening of the FAU Stiles-Nicholson Brain Institute at FAU's John D. MacArthur Campus in Jupiter today with a ribbon-cutting ceremony.

20 Jan 2023

Shielding measures conferred protection to pregnant individuals in early COVID-19 pandemic

Individuals who were already pregnant at the beginning of the COVID-19 pandemic had a 50 percent lower exposure to SARS-CoV-2 compared with those who became pregnant after the pandemic began and the general population, according to a new model created by Weill Cornell Medicine, NewYork-Presbyterian and University of Oxford investigators.

16 Dec 2022

Study identifies a potential pharmacological target for treating COVID-19-associated heart failure

Researchers at the University of Maryland School of Medicine's (UMSOM) Center for Precision Disease Modeling identified how a specific protein in SARS-CoV-2, the virus responsible for COVID-19, damages heart tissue. They then used a drug to reverse the toxic effects of that protein on the heart.

8 Nov 2022