Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

Restless legs syndrome simulator

Restless legs syndrome (RLS) remains a common, yet often undiagnosed, neurological sensorimotor disorder, despite many years of research and increased disease recognition.

20 Jul 2007

New study explains placebo effect

Why do some people experience a “placebo effect” that makes them feel better when they receive a sham treatment they believe to be real — while other people don't respond at all to the same thing, or even feel worse?

19 Jul 2007

Researchers pinpoint brain region linked to placebo effect

Researchers have pinpointed a brain region central to the machinery of the placebo effect, the often controversial phenomenon in which a person's belief in the efficacy of a treatment such as a painkilling drug influences its effect.

19 Jul 2007

UAB receives grants to investigate novel approaches to treat Parkinson's disease

The Michael J. Fox Foundation (MJFF) has awarded two research grants to UAB (University of Alabama at Birmingham) researchers to investigate novel approaches to treat Parkinson's disease.

13 Jul 2007

Neural stem cells for Parkinson's disease

A University of South Florida neuroscientist reports that the cutting-edge research study of human stem cells in primates with Parkinson's disease is compelling on several fronts , particularly how the transplanted cells did their job of easing disease symptoms.

11 Jul 2007

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.

11 Jul 2007

Cigarette smoking associated with reduced risk for developing Parkinson's disease

A pooled analysis of data from previous studies suggests that cigarette smoking appears to be associated with a reduced risk for developing Parkinson's disease, with long-term and current smokers at the lowest risk, according to a report in the July issue of Archives of Neurology.

10 Jul 2007

Anti-smoking drug Chantix works for alcohol too

According to researchers a popular anti-smoking pill may also curb the urge to drink alcohol.

10 Jul 2007

Potential new treatment pathway for Parkinson's

In the vast majority of Parkinson's disease (PD) patients, the disorder arises not because of a genetic defect, but because some external insult triggers the death of dopamine-producing neurons.

9 Jul 2007

New insight into neural stem cells

Scientists have discovered that adult neural stem cells, which exist in the brain throughout life, are not a single, homogeneous group.

9 Jul 2007

Exercise good for those brain cells

According to Swedish researchers exercise may stimulate the production of new brain cells in the area of the brain that is important to memory and learning.

2 Jul 2007

Exercise stimulates the production of new brain cells

Exercise has a similar effect to antidepressants on depression. This has been shown by previous research. Now Astrid Bjornebekk at Karolinska Institutet has explained how this can happen: exercise stimulates the production of new brain cells.

29 Jun 2007

Mothers' second-hand smoke exposure while pregnant linked to children's ADHD

Children whose mothers were exposed to second-hand smoke while they were pregnant have more symptoms of serious psychological problems compared to the offspring of women who had no prenatal exposure to smoke, according to a new University of Washington study.

28 Jun 2007

Early exposure to iron and later exposure to herbicide paraquat may accelerate age-related neurodegeneration

Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinson's disease (PD), according to a new study in mice.

28 Jun 2007

New gene therapy technique for Parkinson's

According to a new study a novel gene therapy technique is safe and may be effective at staving off the worsening symptoms of Parkinson's disease.

25 Jun 2007

Gene therapy for Parkinson's disease is safe and some patients benefit

A novel gene therapy technique is safe and may be effective at staving off worsening symptoms of Parkinson's disease, according to the first scientific review of a dozen patients who have received the treatment over the last three years.

23 Jun 2007

New drug target for the treatment of Parkinson's disease

Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) have identified a potential new drug target for the treatment of Parkinson's disease and possibly for other degenerative neurological disorders.

23 Jun 2007

Link between levels of urate in the blood and risk of Parkinson's disease

In a new, large-scale, prospective study exploring the link between levels of urate in the blood and risk of Parkinson's disease, researchers from the Harvard School of Public Health (HSPH) have found that high levels of urate are strongly associated with a reduced risk of the disease.

23 Jun 2007

Do common treatments for ADHD increase risk of drug abuse?

Parents, doctors, and others have wondered whether common treatments for attention-deficit hyperactivity disorder (ADHD) inadvertently predispose adolescents to future drug abuse.

19 Jun 2007

Researchers use 'genomic pathway' to predict Parkinson's

A new Mayo Clinic study provides strong evidence that the joint effects of common DNA variations in several genes that encode proteins within a well-defined biological pathway largely explain why some persons get Parkinson's disease while others don't, and even predict with great accuracy at what age people might develop their first symptoms.

17 Jun 2007