Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

Genetic variations help predict risk for salt-induced high blood pressure

Researchers led by UVa Health System pathologist Robin Felder, Ph.D., have demonstrated that looking for several variations of genes that control blood pressure can predict the risk for high blood pressure caused by high levels of salt.

23 Feb 2006

SRY gene directly controls neuronal function in the brain

Shaped by much previous research, the prevailing view regarding sex-specific differences in the brain is that they are caused by circulating sex hormones, which are generated outside the brain and influence certain aspects of brain development, as well as brain function in adults.

23 Feb 2006

Researchers create animal model of any schizophrenic characteristics

Researchers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific part of the brain causes cognitive and behavioral impairments mimicking those in human schizophrenics.

20 Feb 2006

Thrill seekers at less risk of Parkinson's disease

According to a new study by British researchers, risk takers stand less chance of getting Parkinson's disease, live longer, and have more friends.

20 Feb 2006

Orexin's role in developing addiction

A molecule in the brain essential for wakefulness and appetite has been found to play a central role in strengthening the neuron connections that lead to addiction.

17 Feb 2006

Gene therapy cures depressed mice

Researchers in the U.S. say that deleting a specific gene in the brain of mice that have been conditioned to be depressed, has the same effect as antidepressants.

13 Feb 2006

Bristol-Myers Squibb and Otsuka Pharmaceutical announce availability of 2 mg Abilify (aripiprazole) tablet

Bristol-Myers Squibb Company and Otsuka Pharmaceutical Co., Ltd. today announced two newly available options of Abilify (aripiprazole) -- a 2 mg tablet strength and a nonrefrigerated oral solution (1 mg/mL).

7 Feb 2006

Alzheimer's disease may be more common than previously recognized

A study published in the January issue of the Annals of Neurology found that neurofibrillary tangles in the substantia nigra, a part of the brain that is subject to cell loss in Parkinson's disease, are associated with gait impairment in older persons with and without dementia.

25 Jan 2006

Gene therapy to turn off Parkinson's

A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease.

23 Jan 2006

Genetics plays a role in drug-seeking behavior

Inbred strains of rats differ in how aggressively they seek cocaine after a few weeks of use, researchers say.

18 Jan 2006

Compounds in blackcurrants could prevent Alzheimer's disease

Compounds in blackcurrants could prevent Alzheimer's disease and the characteristics of British berries suggest they do it best, writes Jennifer Rohn in Chemistry & Industry magazine.

18 Jan 2006

Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive

Researchers at the University of Colorado at Denver and Health Sciences Center’s School of Medicine have uncovered how a gene linked to Parkinson’s disease can keep brain cells alive. The results suggest the possibility for new drugs that might regulate the gene and protect Parkinson’s patients from further cell damage.

29 Dec 2005

Scientists discover how to integrate new neurons into the brain

In experiments with mice, scientists from Johns Hopkins' Institute for Cell Engineering have discovered the steps required to integrate new neurons into the brain's existing operations.

22 Dec 2005

Stem cells provide new way to sneak drugs into brain

One of the great challenges for treating Parkinson's diseases and other neurodegenerative disorders is getting medicine to the right place in the brain.

15 Dec 2005

Eye cell implants improve lives of Parkinson's sufferers

U.S. researchers say that people with Parkinson's disease showed a marked improvement after surgeons implanted in their brains chemical-producing cells taken from the eye of a dead donor.

14 Dec 2005

Cocaine abuse may increase risk of Parkinson's disease

Adults who abuse cocaine might increase their risk of developing Parkinson's disease (PD), and pregnant women who abuse cocaine could increase the risk of their children developing PD later in life, according to results of laboratory studies performed by investigators at St. Jude Children's Research Hospital.

13 Dec 2005

Genetic testing for Parkinson disease, is there a point?

Should we start being genetically tested for Parkinson’s disease (PD)? According to research just published in the December issue of the "journal Movement Disorders" this might be a possibility in the future if you belong to a family affected by G2019S, a genetic mutation responsible for some PD cases.

7 Dec 2005

Now we know - love is the drug you can't forget!

According to researchers at Florida State University who were examining the nature of love it may really, as the poets say, be better to have loved and lost than never to have loved at all.

6 Dec 2005

Disruption of normal gene interaction linked to schizophrenia

Disruption of the normal interaction between the genes PRODH and COMT contributes directly to major symptoms of schizophrenia by upsetting the balance of the brain chemicals glutamate and dopamine, according to a group of investigators that includes a scientist now at St. Jude Children's Research Hospital.

2 Dec 2005

Protein target for Parkinson's disease

Researchers at Johns Hopkins' Institute for Cell Engineering (ICE) have discovered a protein that could be the best new target in the fight against Parkinson's disease since the brain-damaging condition was first tied to loss of the brain chemical dopamine.

2 Dec 2005