Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

Coaxing human embryonic stem cells to make dopamine

For all of the promise embryonic stem cells hold for therapies for neurodegenerative diseases such as Parkinson's disease, they are notoriously difficult to use.

28 Nov 2005

Lowering calorie intake may help Parkinson's disease

A new Oregon Health & Science University and Portland Veterans Affairs Medical Center study suggests that early-stage Parkinson's disease patients who lower their calorie intake may boost levels of an essential brain chemical lost from the neurodegenerative disorder.

20 Nov 2005

New drug far more effective in stopping smokers lighting up

An experimental smoking cessation drug by Pfizer apparently gives smokers better odds at kicking the habit.

16 Nov 2005

Change in neurons' responsiveness marks newly formed sensory associations during learning

During our waking hours, our brains are inundated with sensory information that shifts from one moment to the next.

7 Nov 2005

How the brain tracks time is essential to understanding all its functions

The brain is a "time machine," assert Duke neuroscientists Catalin Buhusi and Warren Meck. And understanding how the brain tracks time is essential to understanding all its functions. The brain's internal clocks coordinate a vast array of activities from communicating, to orchestrating movement, to getting food, they said.

30 Oct 2005

Environment is a major factor influencing the success of the addiction recovery

New research in monkeys suggests that, although living in an "enriched" environment can make someone less vulnerable to abusing cocaine, once started, extended drug abuse can eliminate the social advantage the abuser originally had.

30 Oct 2005

Faulty gene may identify those at risk of schizophrenia

Scientists believe they have discovered a genetic defect which could help explain the biological basis of schizophrenia.

24 Oct 2005

Teens with missing part of a chromosome confirm genetic role in schizophrenia

A study in youth who are missing part of a chromosome is further implicating a suspect gene in schizophrenia.

23 Oct 2005

Dopamine link to psychiatric and neurological disorders

A gene that regulates dopamine levels in the brain is involved in the development of schizophrenia in children at high risk for the disorder, say researchers at the Stanford University School of Medicine, Lucile Packard Children's Hospital and the University of Geneva.

23 Oct 2005

New genetic discovery may help explain why some people develop high blood pressure and others don't

It also gives new insight into how the kidneys govern the balance of salt in the body, a crucial task for regulating blood pressure. And, it reveals how a gene already linked to behavior and mental health can play a role in the body, as well as the brain.

17 Oct 2005

Parkinson's dark period can be minimized or alleviated with the right kind of care

Some people call it "the dark time," the period between when a person is diagnosed with Parkinson's disease and when treatment with medication begins.

26 Sep 2005

Key neural system at risk from prenatal exposure to alcohol

In a study of adult monkeys who were exposed to moderate amounts of alcohol in utero, scientists have found that prenatal exposure to alcohol - even in small doses - has pronounced effects on the development and function later in life of the brain's dopamine system, a critical component of the central nervous system that regulates many regions of the brain.

21 Sep 2005

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Mayo Clinic researchers in collaboration with scientists at Perlegen Sciences, Inc. and funded by the Michael J. Fox Foundation for Parkinson's Research have produced the first large-scale whole genome map of genetic variability associated with Parkinson's disease.

19 Sep 2005

Genetic basis for susceptibility to alcohol abuse confirmed

A new set of experiments in mice confirms that a brain receptor associated with the reinforcing effects of marijuana also helps to stimulate the rewarding and pleasurable effects of alcohol.

12 Sep 2005

Genetic makeup may detemine likely success of quit smoking therapies

A study by researchers at the Transdisciplinary Tobacco Use Research Center (TTURC) of the University of Pennsylvania School of Medicine indicates that a smoker's genetic make-up may affect whether they quit or not while using either bupropion (Zyban) or nicotine replacement therapies (NRTs) such as the nicotine patch or nasal spray.

30 Aug 2005

Benefits of MAO-B inhibitors are small but may be worthwhile in some patients with early Parkinson's disease

A class of drugs known as MAO-B inhibitors may be effective in improving motor symptoms in people with early Parkinson's disease and may delay the need for treatment with other drugs, according to a new systematic review of current evidence.

23 Aug 2005

Rotenone study may lead to novel therapies for Parkinson's disease

Neuroscientists from the University at Buffalo have described for the first time how rotenone, an environmental toxin linked specifically to Parkinson's disease, selectively destroys the neurons that produce dopamine, the neurotransmitter critical to body movement and muscle control.

23 Aug 2005

New insight into the neural computational function represented by "error-related negativity"

Deciphering the subtle, complex electrical signals emanating from the brain has yielded important insights into the still-mysterious neural mechanisms that underlie behavior.

18 Aug 2005

MDMA/Ectasy could lead to new treatments for Parkinson's disease

Researchers at Duke University have revealed new clues about Parkinson's disease which might one day lead to new treatments.

4 Aug 2005

New study aims to understand the intricate biochemistry governing gene regulation

In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems.

4 Aug 2005