Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

Research to investigate new drug for Parkinsons disease

Researchers at the University of Sydney have received a grant to investigate the potential of a new drug to treat the abnormal posture and balance that affects people with Parkinson's disease ultimately confining them to a wheelchair.

2 Aug 2005

Drugs with similar chemical attributes as Ecstasy might offer useful alternatives to current therapies for Parkinson's disease

Amphetamines, including the drug popularly known as Ecstasy, can reverse the symptoms of Parkinson's disease in mice with an acute form of the condition, according to new research at Duke University Medical Center.

2 Aug 2005

Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties

A medication used to ease symptoms of amyotrophic lateral sclerosis, or Lou Gehrig's disease, also is helpful in treating people with treatment-resistant obsessive-compulsive disorder (OCD), according to a pilot study at Yale School of Medicine.

31 Jul 2005

Action of dopamine may be particularly important for understanding psychiatric conditions

Duke University Medical Center researchers have discovered a new mechanism by which chronically high levels of the neurotransmitter dopamine exert their effects on the brain.

28 Jul 2005

First trial of pramipexole for the treatment of fibromyalgia

The mechanism of fibromyalgia, a chronic illness characterized by muscle pain, fatigue, and sleep disturbances, is unknown and medications used to treat it (such as antidepressants, antiepileptics, muscle relaxants, antiinflammatories, sedative hypnotics, pain relievers and nutriceuticals) have had limited success.

28 Jul 2005

Methamphetamine users show symptoms similar to brain injury patients

Because today's methamphetamine is stronger, more potent and wreaks greater havoc on the brain, chronic users exhibit symptoms similar to patients with traumatic brain injury (TBI), according to the Brain Injury Association of Arizona (BIAAZ).

26 Jul 2005

Dopamine plays critical role in the modulation of sleep, wake, and arousal states

Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too.

12 Jul 2005

Gambling and sex addiction caused by Parkinson's drug

According to a doctor at a clinic in the U.S., a certain category of drug, which is often prescribed for Parkinson's disease, can cause some patients to become compulsive gamblers or addicted to sex.

11 Jul 2005

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Just why those with anorexia nervosa are driven to be excessively thin and seem unaware of the seriousness of their condition could be due to over-activity of a chemical system found in a region deep inside the brain, a University of Pittsburgh study suggests.

11 Jul 2005

Dopamine agonist therapy for Parkinson's disease may lead to problem gambling

Eleven patients with Parkinson's disease (PD) developed pathological gambling behavior following dopamine agonist therapy, a drug therapy to control movement problems caused by Parkinson's disease, according to a study posted online which will appear in the September print issue of Archives of Neurology.

11 Jul 2005

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

Analysis of the brain of a patient suffering from Parkinson's Disease has shown that the experimental treatment he received caused regrowth of the nerve fibres that are lost in this disease. The findings are reported in the July issue of Nature Medicine.

6 Jul 2005

Drug therapy may be effective in treating both the manic and depressive phases of bipolar disorder

The condition (bipolar I and II) affects approximately 8 million Americans, who have relied on a combination of drugs to manage their symptoms, and who remain at high risk of committing suicide because of the difficulty in treating the disorder.

6 Jul 2005

Withdrawn experimental drug found to reverse Parkinson's brain damage

Neuroscientists at Frenchay hospital in Bristol have discovered that an experimental drug for Parkinson's disease has been shown to trigger new nerve growth in the brain, the first time any treatment has been found to reverse the brain damage caused by the condition.

5 Jul 2005

Experimental treatment regrows nerve fibres in patient suffering Parkinson's disease

Analysis of the brain of a patient suffering from Parkinson’s Disease has shown that the experimental treatment he received caused regrowth of the nerve fibres that are lost in this disease. The findings are reported in the July issue of Nature Medicine.

30 Jun 2005

Columbia University launches multi-year campaign to support stem cell researc

Columbia University Medical Center (CUMC) has announced that it is halfway toward realizing the first phase of a multi-year campaign to build upon the university’s groundbreaking stem cell research and lead the effort to fully realize the therapeutic potential of stem cells.

16 Jun 2005

Circadian clock gene also plays pivotal role in drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found.

13 Jun 2005

New dopamine transporter gene findings may be relevant for substance abuse, tobacco smoking, and ADHD

Confirming findings in a previous study, Yale researchers observed an altered availability of the dopamine transporter in healthy persons with a genetic variation linked to substance abuse and attention deficit hyperactivity disorder (ADHD).

6 Jun 2005

A protein found naturally in the brain may protect against Parkinson's disease

The findings also may lead to an improved understanding of a disorder called early-onset torsion dystonia.

2 Jun 2005

University of Exeter researchers discover a stroll could help break your smoking habit

Researchers at the University of Exeter have found a new way to help kick the smoking habit - a quick stroll around the block. They examined the effects of a one mile walk on 15 smokers, who hadn't had a puff for 15 hours.

1 Jun 2005

Those old crooners were right, love really can make you crazy

According to scientists brain images show that falling in love can look for all the world like mental illness with a mixture of mania, dementia and obsession that cuts people off from friends and family prompting uncharacteristic behavior which could almost be mistaken for psychosis.

31 May 2005

Dopamine News and Research

Further Reading

Research to investigate new drug for Parkinsons disease

Drugs with similar chemical attributes as Ecstasy might offer useful alternatives to current therapies for Parkinson's disease

Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties

Action of dopamine may be particularly important for understanding psychiatric conditions

First trial of pramipexole for the treatment of fibromyalgia

Methamphetamine users show symptoms similar to brain injury patients

Dopamine plays critical role in the modulation of sleep, wake, and arousal states

Gambling and sex addiction caused by Parkinson's drug

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Dopamine agonist therapy for Parkinson's disease may lead to problem gambling

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

Drug therapy may be effective in treating both the manic and depressive phases of bipolar disorder

Withdrawn experimental drug found to reverse Parkinson's brain damage

Experimental treatment regrows nerve fibres in patient suffering Parkinson's disease

Columbia University launches multi-year campaign to support stem cell researc

Circadian clock gene also plays pivotal role in drug addiction

New dopamine transporter gene findings may be relevant for substance abuse, tobacco smoking, and ADHD

A protein found naturally in the brain may protect against Parkinson's disease

University of Exeter researchers discover a stroll could help break your smoking habit

Those old crooners were right, love really can make you crazy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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