Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Insomnia drug shows potential as an effective treatment for opioid use disorder

The insomnia drug suvorexant (Belsomra) might be an effective treatment for opioid use disorder, according to a preclinical study from Scripps Research.

27 Apr 2023

3D genome mapping may lead to the treatment of deadliest pediatric brain tumors

Researchers led by Sanford Burnham Prebys assistant professor Lukas Chavez, Ph.D., are leveraging the latest technology to take a never-before-seen look at ependymoma, one of the deadliest pediatric brain tumors.

27 Apr 2023

New test reveals FDA-approved antibiotics can effectively treat superbugs

A new test revealed that FDA-approved antibiotics -; available at your neighborhood pharmacy -; can effectively treat superbugs.

27 Apr 2023

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

To highlight how far the field of genetics has come, we spoke with Dr. Francis Collins, the leader of the Human Genome Project about his incredible career in genetics.

25 Apr 2023

New injectable cell therapy shows promise for treating osteoarthritis

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created a promising injectable cell therapy to treat osteoarthritis that both reduces inflammation and also regenerates articular cartilage.

21 Apr 2023

How alcohol intake contributes to increased pain and hypersensitivity

Chronic alcohol consumption may make people more sensitive to pain through two different molecular mechanisms-;one driven by alcohol intake and one by alcohol withdrawal.

21 Apr 2023

Study should spur the development of alternative range of anti-TB inhibitors

Tuberculosis (TB) is one of the deadliest infectious diseases worldwide that is spread in the air like the common cold. TB is caused by the bacterium Mycobacterium tuberculosis (Mtb) and was responsible for approximately 1.6 million deaths in 2021.

20 Apr 2023

Gut bacteria could be responsible for dampening our immune response to COVID-19 vaccine

Gut bacteria that break down a sugar called fucose could be dampening our immune response to the COVID-19 mRNA vaccine, according to a study led by researchers from the Okinawa Institute of Science and Technology.

20 Apr 2023

New biologic inactivates potent opioid and reverses overdose

A new therapeutic designed by Scripps Research chemists can alter the molecular structure of the potent opioid carfentanil, inactivating the opioid and reversing a carfentanil overdose.

18 Apr 2023

AI can identify subtle language and audio changes in patients at early stages of Alzheimer's

New technologies that can capture subtle changes in a patient's voice may help physicians diagnose cognitive impairment and Alzheimer's disease before symptoms begin to show, according to a UT Southwestern Medical Center researcher who led a study published in the Alzheimer's Association publication Diagnosis, Assessment & Disease Monitoring.

12 Apr 2023

Researchers construct super-sized nanocage for delivering larger drug cargoes

Think about how frustrating it is to try to fit a gift into a box that is too small. Sometimes you just need a bigger box.

6 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics, an oncology therapeutics company dedicated to resolving cancer’s complexity to power new treatments for patients, today announced the close of its $28 million series A funding round.

From Mosaic Therapeutics 4 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Company developing targeted oncology therapies spun out of world-leading research at the Wellcome Sanger Institute, in collaboration with the Netherlands Cancer Institute.

From Mosaic Therapeutics 4 Apr 2023

Optibrium appoints computational modelling expert, Dr Hamed Tabatabaei Ghomi as Head of Research

Optibrium, a leading developer of software and AI solutions for drug discovery, today announced the appointment of Dr Hamed Tabatabaei Ghomi as Head of Research.

From Optibrium Ltd. 4 Apr 2023

Oral antiviral CD04872SC shows promise in neutralizing COVID-19 variants, offering hope for broad-spectrum treatment

Researchers discover a small molecule drug candidate that could provide immediate protection against infection with SARS-CoV-2.

4 Apr 2023

New model can speed up the evaluation process for drugs used to combat cervical cancer

Researchers at Oregon State University have created a means of speeding up and improving the evaluation process for drugs used to combat cervical cancer.

31 Mar 2023

Study paves the way for wider applications of cell reprogramming in medicine

Sanford Burnham Prebys researchers have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues.

29 Mar 2023

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

A team of scientists led by the Department of Energy's Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

28 Mar 2023

NPC1L1-EGFP mice enable researchers to fluorescently visualize, evaluate vesicular endocytosis

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease.

28 Mar 2023

Drug Discovery News and Research

Further Reading

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Insomnia drug shows potential as an effective treatment for opioid use disorder

3D genome mapping may lead to the treatment of deadliest pediatric brain tumors

New test reveals FDA-approved antibiotics can effectively treat superbugs

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

New injectable cell therapy shows promise for treating osteoarthritis

How alcohol intake contributes to increased pain and hypersensitivity

Study should spur the development of alternative range of anti-TB inhibitors

Gut bacteria could be responsible for dampening our immune response to COVID-19 vaccine

New biologic inactivates potent opioid and reverses overdose

AI can identify subtle language and audio changes in patients at early stages of Alzheimer's

Researchers construct super-sized nanocage for delivering larger drug cargoes

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Optibrium appoints computational modelling expert, Dr Hamed Tabatabaei Ghomi as Head of Research

Oral antiviral CD04872SC shows promise in neutralizing COVID-19 variants, offering hope for broad-spectrum treatment

New model can speed up the evaluation process for drugs used to combat cervical cancer

Study paves the way for wider applications of cell reprogramming in medicine

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

NPC1L1-EGFP mice enable researchers to fluorescently visualize, evaluate vesicular endocytosis

Drug Discovery - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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