Drug Metabolism News and Research

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Johns Hopkins, IOCB Prague sign drug discovery research agreement

The Johns Hopkins Drug Discovery (JHDD) program, created with the mission of identifying novel drug targets arising from Johns Hopkins faculty research and translating them into new therapeutics, and the Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences (IOCB Prague) have entered into a five-year drug discovery research agreement to develop small-molecule and peptide drugs for a range of therapeutic areas including neurological diseases, cancer and gastrointestinal disorders.

9 Jul 2015

MGH-CEM researchers develop microfabricated device to analyze effects of pro-drugs on cancer cells

A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine has developed a novel approach that dramatically simplifies the evaluation of the liver's drug-metabolizing activity and the potential toxic effects of the products of that activity on other organs.

8 Jul 2015

MGH-CEM researchers develop novel approach to evaluate the liver's drug-metabolizing activity

A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has developed a novel approach that dramatically simplifies the evaluation of the liver's drug-metabolizing activity and the potential toxic effects of the products of that activity on other organs.

17 Jun 2015

GeneSight test better predicts antidepressant outcomes for patients with depression

The combinatorial, multi-gene GeneSight test has been found to better predict antidepressant treatment outcomes for patients with depression, and their use of health care resources, than any of the individual genes that comprise the test, according to a peer-reviewed analysis by investigators from the Mayo Clinic and Assurex Health, and published online by The Pharmacogenomics Journal.

5 Mar 2015

MIT engineers discover way to grow liver-like cells to test potential malaria drugs

In 2008, the World Health Organization announced a global effort to eradicate malaria, which kills about 800,000 people every year. As part of that goal, scientists are trying to develop new drugs that target the malaria parasite during the stage when it infects the human liver, which is crucial because some strains of malaria can lie dormant in the liver for several years before flaring up.

6 Feb 2015

Secrets of success for pioneering research revealed

The British Pharmacological Society has announced the secrets of success for pioneering research along with the outcome of its annual 'Putting UK Pharmacology on the Map' vote. The vote selects sites of special scientific interest linked to achievements in pharmacology based on a ballot of MPs, peers and senior members of the scientific community.

18 Dec 2014

Genetic variations may contribute to treatment-related cognitive problems in children with ALL

Common variations in four genes related to brain inflammation or cells' response to damage from oxidation may contribute to the problems with memory, learning and other cognitive functions seen in children treated for acute lymphoblastic leukemia (ALL), according to a study led by researchers from Boston Children's Hospital, The Children's Hospital at Montefiore, and Dana-Farber/Boston Children's Cancer and Blood Disorders Center.

10 Dec 2014

Discovery could lead to treatments for alcohol-related liver diseases

Researchers at the University of Missouri School of Medicine have identified epigenetic protein changes caused by binge drinking, a discovery that could lead to treatments for alcohol-related liver diseases.

9 Oct 2014

BIOCRATES launches first-ever bile acids kit based on targeted metabolite quantitation

Austrian BIOCRATES Life Sciences AG, internationally renowned developer and marketer of innovative targeted metabolomics solutions, further expands its range of metabolomics-based kits with the addition of its assay for the determination of endogenous bile acids, allowing a panel of up to 19 analytes to be simultaneously quantitated from a single 10 µL sample of human or mouse plasma.

1 Sep 2014

Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

Many African-Americans may not be getting effective doses of the HIV drug maraviroc, a new study from Johns Hopkins suggests. The initial dosing studies, completed before the drug was licensed in 2007, included mostly European-Americans, who generally lack a protein that is key to removing maraviroc from the body.

28 Aug 2014

Syngene International, Bristol-Myers Squibb extend drug discovery and development collaboration

Bristol-Myers Squibb and Syngene International, India's largest contract research organization, today announced a five-year extension of their drug discovery and development collaboration in India.

3 Jun 2014

DNA 'sat nav' allows direct access to homes of ancestors alive 1,000 years ago

Tracing where your DNA was formed over 1,000 years ago is now possible due to a revolutionary technique developed by a team of international scientists led by experts from the University of Sheffield.

2 May 2014

Researchers develop tool to identify biogeography of worldwide individuals

Biogeographical data is useful in screening for disease risk and drug sensitivity associated with certain ethnic groups. A team of researchers, including an investigator from Children's Hospital Los Angeles, has developed a tool to accurately identify the biogeography of worldwide individuals. Previous tools were accurate in identifying place of origin within homogeneous European populations but highly inaccurate for places with significant immigration, such as the U.S.

30 Apr 2014

Promethera Biosciences, EMD Millipore partner to develop ready-to-use microfluidic perfusion liver assay

Promethera Biosciences, a company that develops innovative therapies for the treatment of liver diseases, today announces a collaboration with EMD Millipore to develop an improved ready-to-use microfluidic perfusion liver assay. This new product is designed to perform more robust studies in pre-clinical toxicity and drug metabolism.

11 Mar 2014

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches.

17 Feb 2014

Natural compound coumarins exhibit anti-inflammatory as well as anticoagulant activities

New methods for the laboratory-scale synthesis of coumarin-based drugs were developed in a recent study completed at the University of Eastern Finland. In his doctoral thesis, Lic. Phil. Juri Timonen also developed new analytical methods for the fast identification of natural and non-natural coumarins.

26 Nov 2013

Drug Metabolism News and Research

Johns Hopkins, IOCB Prague sign drug discovery research agreement

MGH-CEM researchers develop microfabricated device to analyze effects of pro-drugs on cancer cells

MGH-CEM researchers develop novel approach to evaluate the liver's drug-metabolizing activity

GeneSight test better predicts antidepressant outcomes for patients with depression

MIT engineers discover way to grow liver-like cells to test potential malaria drugs

Secrets of success for pioneering research revealed

Genetic variations may contribute to treatment-related cognitive problems in children with ALL

Discovery could lead to treatments for alcohol-related liver diseases

BIOCRATES launches first-ever bile acids kit based on targeted metabolite quantitation

Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

Syngene International, Bristol-Myers Squibb extend drug discovery and development collaboration

DNA 'sat nav' allows direct access to homes of ancestors alive 1,000 years ago

Researchers develop tool to identify biogeography of worldwide individuals

Promethera Biosciences, EMD Millipore partner to develop ready-to-use microfluidic perfusion liver assay

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Natural compound coumarins exhibit anti-inflammatory as well as anticoagulant activities

A High-speed, User-friendly Microplate Reader

Researchers study quality, effectiveness and safety of generic drugs used to treat depression

Genetic discovery could take guesswork out of prescribing correct dose of drugs

Few physicians receive adequate training to help patients with chronic pain

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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