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Researchers discover type of "fuel" that the heart uses can contribute to the severity of heart failures

Researchers have determined how metabolic pathways differ between healthy and failing hearts. Normally, a heart derives its energy from a balance of fatty acids and carbohydrates, specifically glucose.

21 Jul 2005

Benign breast disease - not necessarily an indicator of higher breast cancer risk

According to a new study, women diagnosed with a form of benign breast disease, but who do not have a strong family history of breast cancer, have no heightened risk of developing a tumor.

21 Jul 2005

UK medical watchdog wants more proof on value of Alzheimer's drugs

In the UK the country's watchdog for cost-effectiveness in medical treatments, the National Institute for Health and Clinical Excellence (NICE), has asked drug makers for more evidence about the benefits of their Alzheimer's medicines.

21 Jul 2005

New research finds molecular link between obesity and diabetes

Researchers say they have discovered a molecular link between obesity and type 2 diabetes, and the link could be a potential target for new drugs to treat the disease.

21 Jul 2005

Human dummy to teach medics

A new way to teach medical students will be demonstrated for the first time at Bristol University on 21 July 2005, during a joint meeting of the Physiological Society and the Federation of European Physiological Societies.

21 Jul 2005

Hearing protein TRPA1 also involved with pain perception

The same protein that “translates” sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found.

21 Jul 2005

Cocaine induces abnormal enhancement of neuronal connections

Researchers working with rats have zeroed in on the brain circuitry mechanism whose disruption contributes to the impulsive behavior seen in users of cocaine as well as other psychostimulant drugs. The same circuitry has been implicated in such disorders as schizophrenia, depression, and post-traumatic stress disorder, wrote the researchers.

21 Jul 2005

Biologic treatments to treat the physical symptoms of psoriasis

More than 4.5 million adults in the United States have been diagnosed with psoriasis and 21 percent of those have moderate to severe psoriasis. This chronic condition, characterized by thick, red, scaly plaques that itch and bleed, not only makes the activities of daily life difficult, but also can affect a person's emotional well being.

21 Jul 2005

New program will help fill a drug-discovery void as pharmaceutical companies have largely abandoned natural products research

The natural world has been medicine's most effective arsenal, providing life-saving antibiotics and our most potent anti-cancer drugs.

20 Jul 2005

Protein found in fat cells is a newly discovered cause of insulin resistance

A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes.

20 Jul 2005

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

"What we found is that the beta estrogen receptor plays a role in moving the egg outside the ovary so it can be fertilized," said Kenneth Korach, Ph.D., Laboratory Chief at the National Institute of Environmental Health Sciences (NIEHS) where the research was conducted. "We never knew before what function this receptor played in reproduction."

20 Jul 2005

Alendronate combined with calcium and vitamin D almost completely prevented further bone loss in the first 4 months afte liver transplant

A new study found that the drug used to treat osteoporosis, when used in combination with calcium and vitamin D, can prevent the additional bone loss that commonly occurs after liver transplants. The treatment also helped stabilize bone loss in patients who already had osteoporosis, and helped improve their bone mineral density (BMD).

20 Jul 2005

SIRT1 gene suppresses longevity

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide. The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations.

20 Jul 2005

Metformin should be in the first line of defense against type 2 diabetes

A new review of studies confirms that the drug metformin should be in the first line of defense against type 2 diabetes. Using metformin alone can improve control of blood glucose, while also reducing risk factors for heart disease such as excess body weight, cholesterol levels and hypertension, the review found.

20 Jul 2005

America's Children: Key National Indicators of Well-Being 2005

The adolescent birth rate has reached another record low, the death rate for children between ages 1 and 4 is the lowest ever, young children are more likely to receive their recommended immunizations, and fourth graders are scoring better in math, according to a yearly compendium of statistics from federal agencies concerned with children.

20 Jul 2005

Reliable research about the benefits and harms of treatments for malaria in pregnant women is scarce

Few studies compare the effects of different drug regimes in pregnant women, and many of the best studies were conducted in Southeast Asia, where malaria transmission rates are low, says researcher Lois Orton of the University of York in England.

20 Jul 2005

Single dose of antibiotics may be just as effective as multiple doses in preventing infections after an appendectomy

The review found that antibiotic injections do work no matter how diseased the appendix was or whether it was diseased at all. This is significant, because some surgeons contend that antibiotics should be used only when the appendix is at a more advanced stage of disease.

20 Jul 2005

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take."

19 Jul 2005

Study warns against global use of old asthma medicines for kids' coughs

An asthma medicine widely used around the world to stop children's coughs has no provable benefit for that purpose and may cause harm, a new review of existing studies reports.

19 Jul 2005

$New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer$

New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer

When breast cancer spreads to bones, relatively new protective drugs called bisphosphonates can reduce skeletal damage, says a new systematic review of previous studies. While the new treatment approach does not improve survival rates, it can minimize disabling fractures, spinal cord compression and pain.

19 Jul 2005

Drugs News and Research

Researchers discover type of "fuel" that the heart uses can contribute to the severity of heart failures

Benign breast disease - not necessarily an indicator of higher breast cancer risk

UK medical watchdog wants more proof on value of Alzheimer's drugs

New research finds molecular link between obesity and diabetes

Human dummy to teach medics

Hearing protein TRPA1 also involved with pain perception

Cocaine induces abnormal enhancement of neuronal connections

Biologic treatments to treat the physical symptoms of psoriasis

New program will help fill a drug-discovery void as pharmaceutical companies have largely abandoned natural products research

Protein found in fat cells is a newly discovered cause of insulin resistance

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

Alendronate combined with calcium and vitamin D almost completely prevented further bone loss in the first 4 months afte liver transplant

SIRT1 gene suppresses longevity

Metformin should be in the first line of defense against type 2 diabetes

America's Children: Key National Indicators of Well-Being 2005

Reliable research about the benefits and harms of treatments for malaria in pregnant women is scarce

Single dose of antibiotics may be just as effective as multiple doses in preventing infections after an appendectomy

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

Study warns against global use of old asthma medicines for kids' coughs

New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer

Drug Discovery - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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