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Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

9 Jun 2005

Experimental drug works best in combination with older remedy for Alzheimer's disease and other dementias

An experimental drug combined with an already-popular memory-enhancing compound may further delay memory loss in patients with Alzheimer's disease and other dementias, Johns Hopkins University scientists, in collaboration with researchers from University of North Carolina, have found.

9 Jun 2005

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Antiretroviral therapy (ART) programs for treating HIV in developing countries are about as effective as ART programs in developed countries, according to an article in the July 15 issue of Clinical Infectious Diseases, now available online.

9 Jun 2005

Commonly used painkillers for treating inflammation may increase the risk of heart attack

Patients should not stop taking the drugs involved - non-steroidal anti-inflammatory drugs (NSAIDS) - but further investigation into these treatments is needed, say the authors.

9 Jun 2005

Exposing SMA-affected cells to aminoglycoside drugs can increase SMN

MDA grantee Christian Lorson at the University of Missouri was on a team that found that exposing cells carrying a mutation that causes spinal muscular atrophy (SMA) to drugs in the aminoglycoside family helps them produce more of the needed SMN protein, a lack of which leads to SMA.

9 Jun 2005

Designed drug for combined hormone and chemotherapy treatment

The search for new drugs to fight cancer remains at the top of the to do list for pharmaceutical researchers. A recent variation is polymer chemotherapy agents, drugs that have been attached to a "backbone" of long chain molecules.

9 Jun 2005

Lorus Therapeutics receives patent allowance to protect novel anticancer drug

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc. (GeneSense), has received notice from the European Patent Office of its intention to grant GeneSense's application for a patent of its novel antisense drug, GTI-2501.

9 Jun 2005

International efforts to build a prosperous Africa are doomed unless malaria is tackled

In advance of the G8 Ministerial meetings, the first report of the All-Party Parliamentary Malaria Group concludes that unless malaria is tackled as a global crisis with increased and sustained resources, UK’s plans for Africa will fail.

9 Jun 2005

MabThera highly effective in treating rheumatoid arthritis

Results from the DANCER study presented today revealed that MabThera significantly improves symptoms in heavily treated patients who are affected by moderate-to-severe rheumatoid arthritis (RA), a painful and debilitating disease of the joints.

9 Jun 2005

Rituximab, used to treat rheumatoid arthritis (RA) is safe and effective

Professor Paul Emery from the University of Leeds in the UK led the DANCER study (Double blind placebo controlled dose ranging study), designed to confirm the efficacy of rituximab for the treatment of patients with active RA who have failed to improve on one or more disease modifying anti-rheumatic drugs (DMARDs).

9 Jun 2005

Atrial fibrillation may soon have an effective treatment

In laboratory tests in dogs, cardiac researchers at Washington University School of Medicine in St. Louis have found that treatment with anti-inflammatory drugs after heart surgery may lessen or prevent atrial fibrillation. They report their findings in the June 7 issue of Circulation.

8 Jun 2005

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

An international team of chemists and molecular biologists has discovered a fundamental molecular mechanism that seems to play an important role in Alzheimer's disease, Parkinson's disease, mad cow disease and two-dozen other degenerative and fatal diseases.

8 Jun 2005

Several minute intermediate stage in virus-cell fusion may represent a window of opportunity for drug development

To ignite a life-threatening infection in the body, a virus such as HIV invades body cells by first merging, or fusing, with the cell's outer membrane. Once inside the cell, the invading microbe's genetic material takes over, turning the 'host' cell into a factory to produce more copies of the virus, which then spill out to invade other cells in the body.

8 Jun 2005

Prototype drug shows promise in slowing replication of the virus responsible for SARS

A prototype drug created by researchers at the University of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respiratory syndrome, or SARS.

8 Jun 2005

Novel targets found for the development of drugs to complement, or replace, statins

A team of investigators from the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR) and Harvard Medical School has uncovered novel targets for the development of drugs that would potentially complement, or replace, statins in treating heart disease.

8 Jun 2005

New device has the potential to significantly reduce sequencing of the human genome

The sequencing of the human genome was only the beginning of a much more complex task – deciphering the secrets of cellular chemistry and the mechanisms of disease. While the genome serves as a blueprint to understanding the body, proteins represent the materials that carry out these plans.

8 Jun 2005

Arena Pharmaceuticals issued new patent

Arena Pharmaceuticals has announced that it was issued U.S. patent number 6,902,902, entitled "Human G Protein-Coupled Receptors and Modulators Thereof for the Treatment of Metabolic-Related Disorders," by the U.S. Patent Office.

8 Jun 2005

Three pancreatic islet cell transplants successfully treat type 1 diabetic woman

A Davidson woman has been successfully treated for her Type 1 diabetes through a procedure performed at Carolinas Medical Center. Paul F. Gores, M.D., has led a multi-disciplinary team through a series of three pancreatic islet cell transplants since the summer of 2003. The result is a patient who is now insulin-free.

8 Jun 2005

Omega-3 combined with propofol may lead to new drugs to treat breast cancer

Omega-3, the fatty acid found in oily fish, could be combined with a commonly used anesthetic to develop drugs to treat breast cancer, according to research published in the journal Breast Cancer Research.

8 Jun 2005

Arthritis patients still suffer as drugs guidelines are ignored

Access to drugs whose use was approved by the UK's National Institute for Health and Clinical Excellence (NICE) three years ago is still being denied to patients with severe rheumatoid arthritis.

7 Jun 2005

Drugs News and Research

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

Experimental drug works best in combination with older remedy for Alzheimer's disease and other dementias

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Commonly used painkillers for treating inflammation may increase the risk of heart attack

Exposing SMA-affected cells to aminoglycoside drugs can increase SMN

Designed drug for combined hormone and chemotherapy treatment

Lorus Therapeutics receives patent allowance to protect novel anticancer drug

International efforts to build a prosperous Africa are doomed unless malaria is tackled

MabThera highly effective in treating rheumatoid arthritis

Rituximab, used to treat rheumatoid arthritis (RA) is safe and effective

Atrial fibrillation may soon have an effective treatment

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

Several minute intermediate stage in virus-cell fusion may represent a window of opportunity for drug development

Prototype drug shows promise in slowing replication of the virus responsible for SARS

Novel targets found for the development of drugs to complement, or replace, statins

New device has the potential to significantly reduce sequencing of the human genome

Arena Pharmaceuticals issued new patent

Three pancreatic islet cell transplants successfully treat type 1 diabetic woman

Omega-3 combined with propofol may lead to new drugs to treat breast cancer

Arthritis patients still suffer as drugs guidelines are ignored

Drug Discovery - Second Edition eBook

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

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