Rituximab, used to treat rheumatoid arthritis (RA) is safe and effective

NewsGuard 100/100 Score

In the biggest study of its kind, researchers have shown that the drug rituximab, used to treat rheumatoid arthritis (RA) is safe and effective. The results were presented for the first time today (Thursday 9 June), at the Annual European Congress of Rheumatology, EULAR 2005, in Vienna.

Professor Paul Emery from the University of Leeds in the UK led the DANCER study (Double blind placebo controlled dose ranging study), designed to confirm the efficacy of rituximab for the treatment of patients with active RA who have failed to improve on one or more disease modifying anti-rheumatic drugs (DMARDs). Rituximab targets a specific type of immune cell and helps to control inflammation and pain.

The DANCER study involved 465 men and women who had had arthritis for about 10 years. It examined the relative efficacy of two different dose levels of rituximab, as well as the role of anti-inflammatory drugs, glucocorticoids (steroids), in the treatment programme.

Speaking at the Vienna congress, Professor Emery said, "The results of the study's 24 week-analysis showed that both doses of rituximab were highly effective, and significantly better than a placebo. It seems that that the higher of the two doses produced the best effects."

An intravenous infusion of glucocorticoids alone before the treatment began was compared with a pre-infusion plus a short oral course. Either way, the steroids did not enhance the efficacy of rituximab. "Our analyses demonstrate that rituximab is safe and well-tolerated, consistent with that seen previously in studies of rituximab, in patients with RA," Professor Emery said.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Acupuncture may lower stroke risk in rheumatoid arthritis patients