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HonorHealth Research Institute treats first patient in global trial targeting aggressive melanoma

HonorHealth Research Institute recently treated the first patient in a 50-site international clinical trial that will test a new type of therapy aimed at difficult-to-treat melanoma, an aggressive type of skin cancer.

29 Apr 2025

New CAR T cell therapy shows promise for treating advanced thyroid cancer

A new chimeric antigen receptor (CAR) T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, according to researchers from The University of Texas MD Anderson Cancer Center.

29 Apr 2025

$Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma$

Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma

Researchers from the Sant Pau Research Institute (IR Sant Pau), in collaboration with Sant Pau Hospital and the Josep Carreras Leukaemia Research Institute, have developed an innovative CAR-T cell therapy targeting the CD30 protein (HSP-CAR30), which has shown high efficacy in patients with refractory CD30+ lymphoma.

29 Apr 2025

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

Neoadjuvant PD-1 blockade with dostarlimab achieved high rates of organ preservation in patients with early-stage mismatch repair-deficient (dMMR) solid tumors across multiple types. Most patients avoided surgery with durable disease control, reshaping potential cancer treatment pathways.

28 Apr 2025

UQ begins first human trial of immunotherapy for Type 1 diabetes

Researchers at The University of Queensland have dosed 5 participants in the first clinical trial of a potentially revolutionary immunotherapy drug to treat Type 1 diabetes.

28 Apr 2025

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

The HER2-targeted therapy zongertinib demonstrated clinical benefits for previously treated patients with advanced HER2-mutant non-small cell lung cancer – particularly those with specific HER2 mutations – with manageable side effects, according to results from the Phase Ia/Ib Beamion LUNG-1 trial led by researchers from The University of Texas MD Anderson Cancer Center.

28 Apr 2025

New topical gel reduces painful rash from colorectal cancer treatment

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center and The University of Texas MD Anderson Cancer Center have demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

28 Apr 2025

Pre and post-surgical immunotherapy improves survival in head and neck cancer patients

Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.

27 Apr 2025

MD Anderson researchers present promising clinical trial results at AACR 2025

Researchers from The University of Texas MD Anderson Cancer Center will present promising results from clinical trials in three minisymposia abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2025.

26 Apr 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

An investigational monoclonal antibody called bentracimab can safely and effectively reverse potentially catastrophic bleeding complications linked to ticagrelor, a common drug used to treat patients with acute coronary syndromes, prior heart attack, stroke, and coronary artery disease.

24 Apr 2025

Global clinical trial tests two anti-inflammatory drugs for long COVID

Spanning four continents and enrolling hundreds of people, a new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID, scientists from Western University and the Schmidt Initiative for Long Covid (SILC) announced today.

24 Apr 2025

Baloxavir marboxil shows promise in reducing household flu spread

One dose of the antiviral baloxavir marboxil lowers the chance of transmitting the influenza virus to family members by about 30%, according to research in the New England Journal of Medicine.

24 Apr 2025

Daily peanut doses help adults overcome severe allergies

The first clinical trial to test whether adults allergic to peanuts can be desensitised has shown great success with two thirds of the cohort consuming the equivalent of five peanuts without reacting.

23 Apr 2025

One RSV shot cuts severe lung infections in older adults for three seasons, trial shows

A phase 3 trial involving nearly 25,000 older adults across 17 countries found that a single dose of the RSVPreF3 OA vaccine reduced RSV-related lower respiratory tract disease by 63% over three seasons. Protection remained substantial despite waning, with similar efficacy to a two-dose regimen and a favorable safety profile.

23 Apr 2025

Varenicline found to help teens and young adults quit vaping

A new study by investigators from Mass General Brigham showed that teens and young adults who took varenicline-an FDA-approved, twice-daily smoking cessation pill for adults-are more than three times as likely to successfully quit vaping compared to those who received only behavioral counseling. Results are published in JAMA.

23 Apr 2025

Hyperbaric oxygen therapy brings long-term relief after cancer radiation

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Drug Trial News

HonorHealth Research Institute treats first patient in global trial targeting aggressive melanoma

New CAR T cell therapy shows promise for treating advanced thyroid cancer

Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

UQ begins first human trial of immunotherapy for Type 1 diabetes

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

New topical gel reduces painful rash from colorectal cancer treatment

Pre and post-surgical immunotherapy improves survival in head and neck cancer patients

MD Anderson researchers present promising clinical trial results at AACR 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

Global clinical trial tests two anti-inflammatory drugs for long COVID

Baloxavir marboxil shows promise in reducing household flu spread

Daily peanut doses help adults overcome severe allergies

One RSV shot cuts severe lung infections in older adults for three seasons, trial shows

Varenicline found to help teens and young adults quit vaping

Hyperbaric oxygen therapy brings long-term relief after cancer radiation

UCLA launches trial of wearable ADHD therapy for children exposed to alcohol in the womb

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