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Pacibekitug safely reduces inflammatory biomarkers in kidney disease patients

The interleukin-6 (IL-6) antibody, pacibekitug, produced sustained reductions in inflammatory biomarkers in patients with chronic kidney disease at high inflammatory risk, according to results from the phase II TRANQUILITY trial presented in a Hot Line session today at ESC Congress 2026.

29 Aug 2026

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy.

From Dana-Farber Cancer Institute, Inc. 29 Aug 2026

Aficamten improves symptom burden and exercise capacity in patients with non-obstructive HCM

Aficamten treatment was associated with significant improvements in symptom burden and exercise capacity in patients with symptomatic non-obstructive hypertrophic cardiomyopathy, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

28 Aug 2026

POET-II trial reduces antibiotic duration for infective endocarditis by two weeks

A response-tailored strategy reduced antibiotic duration by two weeks without compromising the safety of patients with left-sided infective endocarditis.

28 Aug 2026

Oral anticoagulants benefit patients with atrial fibrillation at intermediate stroke risk

Oral anticoagulant therapy lowered the risk of adverse clinical events compared with no anticoagulation in patients with atrial fibrillation at intermediate stroke risk, according to results from the SINGLE-AF trial presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

28 Aug 2026

African Bundibugyo ebolavirus vaccine candidate to be advanced to clinical trials

Leading African biopharmaceutical company Minapharm Group, headquartered in Egypt with subsidiaries in Berlin, will receive up to US$16.5 million from the Coalition for Epidemic Preparedness Innovations (CEPI) to advance the development of a Bundibugyo ebolavirus vaccine candidate, strengthening efforts to develop vaccines to combat the fastest-growing and second-largest Ebola outbreak on record affecting the Democratic Republic of the Congo (DRC).

28 Aug 2026

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

The CARDIO-TTRansform trial investigating eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy did not meet its primary efficacy endpoint, according to results presented in a Hot Line session today at ESC Congress 2026.

28 Aug 2026

Early rasburicase treatment linked to better outcomes in tumor lysis syndrome

Tumor lysis syndrome (TLS) is a life-threatening emergency that occurs when large numbers of cancer cells break down rapidly, releasing substances such as uric acid into the bloodstream that can damage the kidneys and cause serious complications.

27 Aug 2026

$15 million trial aims to improve treatment decisions for older AML patients

A newly funded national clinical trial initiative will gather critical evidence to determine the best treatment strategies for older adults with acute myeloid leukemia (AML), an aggressive, fast-moving blood cancer that leaves a substantial proportion of older patients facing uncertainty about whether to proceed to stem cell transplantation or continue non-transplant therapy.

27 Aug 2026

Alliance releases new film highlighting the critical role of clinical trials

The Alliance for Clinical Trials in Oncology has released a film highlighting the critical role of participant involvement in advancing cancer research and improving care.

27 Aug 2026

Optimized EAP regimen delivers outstanding mobilization effects in multiple myeloma and lymphoma patients

This prospective, multicenter phase II study was conducted across 12 medical institutions in China and registered at ClinicalTrials.gov (NCT05536154).

27 Aug 2026

FDA approves first RAS-targeted therapy for metastatic pancreatic cancer

27 Aug 2026

Real-world Chinese study confirms benefits of niraparib maintenance therapy for ovarian cancer

Ovarian cancer remains one of the most lethal gynecologic malignancies worldwide, with a high risk of recurrence even after successful initial treatment.

26 Aug 2026

Scientists identify molecule driving one of the deadliest forms of breast cancer

Australian researchers have uncovered a promising new way to tackle one of the most aggressive forms of breast cancer, raising hopes for more effective treatments to stop the disease from spreading.

21 Aug 2026

Federal and industry sponsors play complementary roles in cancer clinical trials

A comparative study of the cancer clinical trial portfolios supported by federal funding versus industry funding reveals they have distinct, interdependent roles in cancer research.

20 Aug 2026

Semaglutide trial targets people with liver disease, obesity and alcohol addiction

A new study -- co-led by the University of Plymouth, University Hospitals Plymouth NHS Trust, and the NIHR Biomedical Research Centre: Nottingham -- is being launched into a treatment for people impacted by liver disease, obesity and alcohol addiction.

19 Aug 2026

Drug Trial News

Pacibekitug safely reduces inflammatory biomarkers in kidney disease patients

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

Aficamten improves symptom burden and exercise capacity in patients with non-obstructive HCM

POET-II trial reduces antibiotic duration for infective endocarditis by two weeks

Oral anticoagulants benefit patients with atrial fibrillation at intermediate stroke risk

African Bundibugyo ebolavirus vaccine candidate to be advanced to clinical trials

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

Early rasburicase treatment linked to better outcomes in tumor lysis syndrome

$15 million trial aims to improve treatment decisions for older AML patients

Alliance releases new film highlighting the critical role of clinical trials

Optimized EAP regimen delivers outstanding mobilization effects in multiple myeloma and lymphoma patients

FDA approves first RAS-targeted therapy for metastatic pancreatic cancer

Real-world Chinese study confirms benefits of niraparib maintenance therapy for ovarian cancer

Scientists identify molecule driving one of the deadliest forms of breast cancer

Federal and industry sponsors play complementary roles in cancer clinical trials

Semaglutide trial targets people with liver disease, obesity and alcohol addiction

Nanoplatelets, a potential drug delivery vehicle for targeted cancer therapy

Britons embrace DIY health checks

Personalized T-cell therapy eliminates advanced kidney tumor in teenager

HonorHealth begins trial of dendritic cell vaccine for advanced melanoma

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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