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New chemotherapy regimen improves fertility outcomes in young Hodgkin's lymphoma patients

Young patients with advanced Hodgkin's lymphoma, a cancer of the lymphatic system, now have a better chance of having their own children after treatment.

10 Jul 2025

Updated NeoVax cancer vaccine shows improved immune response in melanoma trial

Results of a Dana-Farber Cancer Institute-initiated phase 1 clinical trial for patients with melanoma show that an updated formula and delivery of the NeoVax personalized cancer vaccine called NeoVaxMI is safe, feasible, and improves the vaccine-specific immune response compared to previous trials of the platform.

10 Jul 2025

Combination therapy sets new survival standard for advanced biliary tract cancer

In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced biliary tract cancer (aBTC), researchers have shown that after three years more than twice as many study participants treated with durvalumab plus GemCis had survived compared to those treated with a placebo plus GemCis.

10 Jul 2025

Fluorescent-guided nerve imaging agent shows promise for use in humans

For the first time, a fluorescent-guided nerve imaging agent shows promise for use in humans, according to a paper published in Nature Communications.

9 Jul 2025

New TB drugs show promise with fewer side effects than linezolid

The drugs, sutezolid and delpazolid, have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid, with potential to replace this current cornerstone in the treatment of drug-resistant TB.

8 Jul 2025

Researchers explore new therapies to prevent organ rejection without immunosuppressive drugs

While immunosuppressive medications are critical to prevent rejection of transplant organs, they also come with plenty of downsides.

7 Jul 2025

Fluorescent drug helps surgeons see nerves clearly during complex procedures

When surgeons dissect tissue to remove a tumor or make a repair they must work cautiously, relying on electrophysical monitors and their own anatomical knowledge to avoid cutting nerves, which could complicate the patient's recovery.

4 Jul 2025

Nanoemulsion form of vitamin D3 could improve core manifestations of autism

This study investigates the effectiveness of a vitamin D3-loaded nanoemulsion in improving the core symptoms of autism spectrum disorder (ASD) in children.

2 Jul 2025

Clinical trial examines whether Ambroxol can slow dementia in people with Parkinson's

Dementia poses a major health challenge with no safe, affordable treatments to slow its progression.

1 Jul 2025

HonorHealth study shows major breakthrough in treating structural shock

An 8-year HonorHealth Research Institute clinical trial, using non-surgical techniques, showed 86% of patients with a type of usually fatal low blood pressure known as 'structural shock' survived at least 3 months, while 73% survived at least 6 months, according to a study presented here at a major heart convention.

27 Jun 2025

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Insilico Medicine, a clinical-stage biotechnology company driven by generative artificial intelligence (AI), today announces that the first patient has been dosed in a global multicenter clinical trial (NCT06414460) to evaluate ISM3412, a potentially best-in-class, AI-empowered MAT2A inhibitor with novel structure, in patients with locally advanced and metastatic solid tumors.

27 Jun 2025

Common autoimmune drug shown to help patients with giant cell arteritis

A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant cell arteritis, according to findings from a team at the Perelman School of Medicine at the University of Pennsylvania published in the New England Journal of Medicine.

25 Jun 2025

Tirzepatide rewires appetite and slashes calorie intake in new obesity trial

A 6-week randomized trial found that tirzepatide significantly reduced energy intake, appetite, and cravings in adults with overweight or obesity, outperforming liraglutide and placebo. Brain imaging revealed that tirzepatide also lowered neural responses to high-fat, high-sugar food cues, offering mechanistic insight into its potent weight-loss effects.

25 Jun 2025

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

Researchers found that once-monthly maridebart cafraglutide led to substantial weight loss and improved glycemic control in adults with obesity, with or without diabetes, in a phase 2 randomized trial. The drug demonstrated an acceptable safety profile and supports further study in phase 3 trials.

24 Jun 2025

ADC189 shows promise as a single-dose treatment for influenza

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and mortality.

24 Jun 2025

Clinical trial finds new benefits of semaglutide for adults with type 1 diabetes

A new clinical trial found that taking a popular diabetes and weight-loss drug once weekly significantly improves blood sugar and leads to substantial weight loss in adults with Type 1 diabetes who use automated insulin delivery systems.

23 Jun 2025

Genetically engineered skin grafts help heal chronic wounds in patients with epidermolysis bullosa

Skin grafts genetically engineered from a patient's own cells can heal persistent wounds in people with an extremely painful dermatologic disease, a Stanford Medicine-led clinical trial has shown.

23 Jun 2025

Cagrilintide and semaglutide together drive record weight loss in global trial

A 68-week phase 3 trial found that coadministered cagrilintide and semaglutide led to significant and clinically meaningful weight loss in adults with obesity but no diabetes. The combination outperformed either drug alone and improved multiple cardiometabolic health markers.

23 Jun 2025

Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Once-weekly amycretin, a novel peptide activating GLP-1, amylin, and calcitonin receptors, produced rapid, substantial, and sustained weight loss in adults with overweight or obesity during a phase 1b/2a trial. The treatment was generally well tolerated, with mostly mild to moderate gastrointestinal side effects, supporting further investigation in larger, longer studies.

23 Jun 2025

BMJ investigation raises new concerns over ticagrelor approval trials

In a follow up investigation into the multibillion dollar drug ticagrelor, The BMJ has uncovered fresh concerns, this time in key platelet studies used in its FDA approval.

21 Jun 2025

Drug Trial News

New chemotherapy regimen improves fertility outcomes in young Hodgkin's lymphoma patients

Updated NeoVax cancer vaccine shows improved immune response in melanoma trial

Combination therapy sets new survival standard for advanced biliary tract cancer

Fluorescent-guided nerve imaging agent shows promise for use in humans

New TB drugs show promise with fewer side effects than linezolid

Researchers explore new therapies to prevent organ rejection without immunosuppressive drugs

Fluorescent drug helps surgeons see nerves clearly during complex procedures

Nanoemulsion form of vitamin D3 could improve core manifestations of autism

Clinical trial examines whether Ambroxol can slow dementia in people with Parkinson's

HonorHealth study shows major breakthrough in treating structural shock

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Common autoimmune drug shown to help patients with giant cell arteritis

Tirzepatide rewires appetite and slashes calorie intake in new obesity trial

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

ADC189 shows promise as a single-dose treatment for influenza

Clinical trial finds new benefits of semaglutide for adults with type 1 diabetes

Genetically engineered skin grafts help heal chronic wounds in patients with epidermolysis bullosa

Cagrilintide and semaglutide together drive record weight loss in global trial

Amycretin delivers unprecedented weight loss in early trial for obesity treatment

BMJ investigation raises new concerns over ticagrelor approval trials

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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