Electron Microscopy News and Research

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Retina scans could help identify Alzheimer’s

Researchers at the Cedars-Sinai and NeuroVision Imaging LLC have made it possible to identify the pathological markers of Alzheimer’s using retinal scans. These scans are non- invasive and could be performed routinely in future to detect this dreaded form of degenerative brain disease. The paper was published online in the JCI Insight on 17th of August.

22 Aug 2017

Noninvasive retinal imaging may detect pathological hallmarks of Alzheimer's disease

A study led by researchers at Cedars-Sinai and NeuroVision Imaging LLC provides the scientific basis for using noninvasive eye imaging to detect the pathological hallmarks of Alzheimer's.

22 Aug 2017

Novel nanolaser can serve as super-bright probe to detect and kill metastasized cancer cells

A nanolaser known as the spaser can serve as a super-bright, water-soluble, biocompatible probe capable of finding metastasized cancer cells in the bloodstream and then killing these cells, according to a new research study.

22 Aug 2017

Nanomaterial wrap for improved tissue imaging

Researchers at Tokai University describe in Advanced Materials how wrapping biological tissue in a nanosheet of a particular organic material results in high-quality microscopy images. Application of the wrap prevents the sample from drying out, and hence from shrinking, enabling larger image-recording times.

20 Aug 2017

Scientists map learning and memory center of fruit fly larva brain

A Johns Hopkins University mathematician and computer scientist joined an international team of neuroscientists to create a complete map of the learning and memory center of the fruit fly larva brain, an early step toward mapping how all animal brains work.

11 Aug 2017

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Thermo Fisher Scientific, the world leader in serving science, has extended its leadership in cryo-electron microscopy (cryo-EM) with the introduction of two new instruments: the Thermo Scientific Krios G3i and the Thermo Scientific Glacios cryo-transmission electron microscopes (cryo-TEMs).

From Thermo Fisher Scientific Inc. 9 Aug 2017

Expert highlights CRISPR’s applications, limitations, and ethical concerns

"Good morning, doctor, I am here for my gene editing appointment." In the future, could this be a greeting heard in physician offices around the world? With the introduction of CRISPR technology, genetic material can now be more easily and precisely edited, even creating changes that can subsequently be inherited by offspring.

1 Aug 2017

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA.

29 Jul 2017

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

How can six and half feet of DNA be folded into the tiny nucleus of a cell? Researchers funded by the National Institutes of Health have developed a new imaging method that visualizes a very different DNA structure, featuring small folds of DNA in close proximity.

27 Jul 2017

CUMC researchers capture first snapshot of key brain receptor in action

Columbia University Medical Center researchers have captured the first three-dimensional snapshots of the AMPA-subtype glutamate receptor in action. The receptor, which regulates most electrical signaling in the brain, is involved in several important brain activities, including memory and learning.

24 Jul 2017

New technique physically expands tissues to improve breast cancer diagnosis

A Ludwig Cancer Research study offers pathologists a quick, cheap and reliable tool to diagnose diseases such as early breast cancer with a conventional optical microscope.

18 Jul 2017

Scientists provide detailed view of tau protein structures found in Alzheimer's disease

New research by scientists at the MRC Laboratory of Molecular Biology in the United Kingdom and Indiana University School of Medicine gives the most detailed view yet of tau protein structures found in Alzheimer's disease.

6 Jul 2017

Alzheimer’s disease specific brain deposits photographed for the first time in vivid detail

Scientists from the Britain's Medical Research Council Laboratory of Molecular Biology have for the first time, clearly pictured what the deposits typically seen in a person with Alzheimer’s disease look like. This is a breakthrough in neurodegenerative diseases. The latest study showing the structure of tau protein was published in the journal Nature.

5 Jul 2017

Study: Gadolinium may accumulate in brain tissues of patients without intracranial abnormalities

Minute traces of gadolinium, the contrast agent used to enhance MR images, are often retained in the brain tissue of patients years after undergoing MRI. Some studies have suggested this deposition was limited to patients with underlying brain pathology, such as a tumor or infection.

28 Jun 2017

Researchers shed light on molecular mechanisms of ovarian cancer metastasis

With 20,000 diagnoses each year, ovarian cancer is the ninth most common cancer and fifth leading cause of cancer death among women in the United States.

28 Jun 2017

Morgridge researchers reveal complex viral replication process in unprecedented detail

In the fight against the viruses that invade everyday life, seeing and understanding the battleground is essential. Scientists at the Morgridge Institute for Research have, for the first time, imaged molecular structures vital to how a major class of viruses replicates within infected cells.

27 Jun 2017

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.

16 Jun 2017

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers from the Institute of Neurosciences of the UB and from IDIBAPS together with a team from the University Pierre and Marie Curie and the Institute du Fer à Moulin, published a study in Nature Communications, which demonstrates that the regulation in Pyk2, a protein-tyrosine kinase, causes alterations of the synaptic plasticity involved in memory tasks, associated with the hippocampus in mouse models of neurodegenerative diseases, such as Huntington's.

13 Jun 2017

Researchers explore sea urchin protein to understand self-assembly of skeletal structures

Calcium carbonate, or CaCO3, comprises more than 4% of the earth's crust. Its most common natural forms are chalk, limestone, and marble, produced by the sedimentation of the shells of small fossilized snails, shellfish, and coral over millions of years.

8 Jun 2017

Researchers capture first cryo-EM snapshots of key cellular receptor in action

Researchers at the University of Michigan, Stanford University and biotech company ConfometRx have captured the first cryo-electron microscopy snapshots of a key cellular receptor in action.

25 May 2017

Electron Microscopy News and Research

Retina scans could help identify Alzheimer’s

Noninvasive retinal imaging may detect pathological hallmarks of Alzheimer's disease

Novel nanolaser can serve as super-bright probe to detect and kill metastasized cancer cells

Nanomaterial wrap for improved tissue imaging

Scientists map learning and memory center of fruit fly larva brain

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Expert highlights CRISPR’s applications, limitations, and ethical concerns

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

CUMC researchers capture first snapshot of key brain receptor in action

New technique physically expands tissues to improve breast cancer diagnosis

Scientists provide detailed view of tau protein structures found in Alzheimer's disease

Alzheimer’s disease specific brain deposits photographed for the first time in vivid detail

Study: Gadolinium may accumulate in brain tissues of patients without intracranial abnormalities

Researchers shed light on molecular mechanisms of ovarian cancer metastasis

Morgridge researchers reveal complex viral replication process in unprecedented detail

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers explore sea urchin protein to understand self-assembly of skeletal structures

Researchers capture first cryo-EM snapshots of key cellular receptor in action

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Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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