Emerging Disease News and Research

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Infinity announces data from IPI-145 Phase 1 study in patients with advanced hematologic malignancies

Infinity Pharmaceuticals, Inc. today announced Phase 1 data from an ongoing study of IPI-145, its potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma in patients with advanced hematologic malignancies, or potentially fatal blood cancers.

25 Jun 2013

Scientists use mathematical tools to identify animal species that transmit diseases to humans

Spanish and US scientists have successfully identified animal species that can transmit more diseases to humans by using mathematical tools similar to those applied to the study of social networks like Facebook or Twitter.

12 Jun 2013

Leptospirosis: The newest public health threat in Africa

The newest public health threat in Africa, scientists have found, is coming from a previously unknown source: the banded mongoose.

15 May 2013

Virginia Tech researchers identify leptospirosis as a major health threat in Botswana

The newest public health threat in developing countries may not be a cinematic-quality emerging disease but actually a disease from animals that was identified more than 100 years ago.

15 May 2013

Study reveals humans are passing antibiotic resistance to wildlife in protected areas

A team of Virginia Tech researchers has discovered that humans are passing antibiotic resistance to wildlife, especially in protected areas where numbers of humans are limited.

25 Apr 2013

New data on T cells' protective role suggests need for new approach to dengue vaccine design

As efforts to create a strong and effective vaccine for the dreaded dengue virus continue to hit snags, a new study from researchers at the La Jolla Institute for Allergy & Immunology offers surprising evidence that suggests the need for a revamped approach to dengue vaccine design.

15 Apr 2013

Princeton metabolic model can predict how parasites would fare in altered climates

Knowing the temperatures that viruses, bacteria, worms and all other parasites need to grow and survive could help determine the future range of infectious diseases under climate change, according to new research.

27 Feb 2013

New research focuses on rapid identification of disease outbreaks

EcoHealth Alliance, the nonprofit organization that focuses on local conservation and global health issues, announced new research focused on the rapid identification of disease outbreaks in the peer reviewed publication, Journal of the Royal Society Interface.

15 Feb 2013

Infinity announces new data from IPI-145 Phase 1 trial on advanced hematologic malignancies

Infinity Pharmaceuticals, Inc. today announced new data from its ongoing Phase 1, open-label, dose-escalation trial of IPI-145, the company's potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma, in patients with advanced hematologic malignancies.

11 Dec 2012

More work needed to predict, prevent zoonotic pandemics

We are on the brink of being able to predict zoonotic pandemics, say public health researchers in The Lancet. However, more work will be required to turn this goal into a reality.

7 Dec 2012

Guineafowl may spread Crimean-Congo hemorrhagic fever virus

Turkey raises and releases thousands of non-native guineafowl to eat ticks that carry the deadly Crimean-Congo hemorrhagic fever virus. Yet research suggests guineafowl eat few ticks, but carry the parasites on their feathers, possibly spreading the disease they were meant to stop, says a Turkish biologist working at the University of Utah.

30 Nov 2012

Genetic study: Novel coronavirus most closely related to viruses in bats

The virus that is causing alarm among global public health authorities after it killed a man in Jeddah, Saudi Arabia earlier this year and is now linked to two other cases of disease is a novel type of coronavirus most closely related to viruses found in bats, according to a genetic analysis to be published in mBio-, the online open-access journal of the American Society for Microbiology, on November 20.

22 Nov 2012

Ebola, Marburg and Lassa viruses must be designated as emerging diagnoses

The Ebola, Marburg and Lassa viruses are commonly referred to as emerging diseases, but leading scientists say these life-threatening viruses have been around for centuries.

15 Nov 2012

Multi-system exposure related illness (MERI)

The Global Health Network has released a new paper titled “Common Toxins in our Homes, Schools and Workplaces.” According to an Environmental Protection Agency (EPA) spokesman, indoor air pollution causes 50% of illnesses globally. This statistic should catch the attention of every physician, every lawmaker and every layperson reading this paper. That’s more than all the cancers and all the heart disease combined. It is time we started to pay more attention to the indoor air we breathe. It is staggering to comprehend the enormous impact on our global society as literally millions of individuals and families are harmed by contaminants inside our homes, schools and workplaces.

16 Oct 2012

Meritage commences OBS Phase 2 clinical trial for eosinophilic esophagitis

Meritage Pharma, Inc. announced that it has initiated a Phase 2 clinical trial to evaluate oral budesonide suspension (OBS) for the treatment of adolescents and young adults with eosinophilic esophagitis (EoE), an allergic inflammatory condition of the esophagus. EoE is a chronic disease characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation.

13 Aug 2012

Study: 13 zoonoses responsible for 2.4B cases of human illness per year

A new global study mapping human-animal diseases like tuberculosis (TB) and Rift Valley fever finds that an "unlucky" 13 zoonoses are responsible for 2.4 billion cases of human illness and 2.2 million deaths per year. The vast majority occur in low- and middle-income countries.

5 Jul 2012

Data from Infinity’s IPI-145 pre-clinical study on inflammatory diseases

Infinity Pharmaceuticals, Inc. today reported preclinical data for IPI-145, the company's oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma. The data demonstrate potent PI3K-delta and -gamma inhibition in biochemical, cellular and whole blood assays and activity in multiple preclinical models of inflammatory disease, including rheumatoid arthritis and asthma.

28 Jun 2012

Infinity voluntarily stops saridegib Phase 2 trial for chondrosarcoma

Infinity Pharmaceuticals, Inc. today announced interim data from its Phase 2, double-blind, randomized, placebo-controlled study of saridegib (IPI-926) in patients with metastatic or locally advanced, inoperable chondrosarcoma. The primary endpoint of the Phase 2 study was progression-free survival.

18 Jun 2012

ICDs may increase risk of complications in patients with infective endocarditis

Patients with infective endocarditis involving implanted cardiac devices experience a high rate of complications such as valve infections, heart failure, and persistent bacteremia, and high in-hospital and 1-year mortality rates, particularly if there is valve involvement, according to a study in the April 25 issue of JAMA.

24 Apr 2012

New data from Infinity saridegib and gemcitabine Phase 1b/2 combination trial on pancreatic cancer

Infinity Pharmaceuticals, Inc. today announced updated data from the Phase 1b portion of an ongoing Phase 1b/2 clinical trial of saridegib in combination with the chemotherapy gemcitabine in patients with previously untreated, metastatic pancreatic cancer.

20 Jan 2012