Encephalopathy News and Research

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Rapid infusion of NaHCO3 bolus after extensive resuscitation leads to higher blood flows to the brain and heart

A new study examines the effect of rapid infusion of 2meq/kg of sodium bicarbonate (NaHCO3) in an ovine model on gas exchange and coronary and cerebral perfusion in the immediate post-resuscitation phase.

22 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons -; more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Severe outcomes in hospitalized children during the Omicron BA.2-dominated fifth wave in Hong Kong

A recent study investigated the disease severity of SARS-CoV-2 Omicron BA.2 infection among Hong Kong children.

28 Mar 2022

University of Kentucky begins world’s first clinical trial for LATE

The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

17 Mar 2022

Current evidence that vitamin D is effective against COVID-19 neurological sequelae

Researchers analyze the available scientific evidence supporting vitamin D as a neuroprotective agent against the neurological sequelae of COVID-19.

14 Mar 2022

Two new studies shed light on tau’s role in Alzheimer’s disease psychosis

Helping to advance Alzheimer’s disease (AD) research, scientists from The Feinstein Institutes for Medical Research have published two studies supporting the connection of tau – a protein in the brain that forms neurofibrillary tangles that are a hallmark of AD and have been linked to chronic traumatic encephalopathy (CTE) from head trauma – with psychosis in AD.

8 Mar 2022

How have human organoids been used in research to study SARS-CoV-2?

In a recent review published in the journal Organoids, scientists have presented an overview on the use of human stem cell-derived organoids in understanding functionality and cellular tropism of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), a deadly beta-coronavirus responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic.

7 Mar 2022

Study to examine the risks for brain disorders from repetitive head impacts in contact sports

Internationally-renowned researchers from Boston University and the University of California, San Francisco) are launching a new study, called the Head Impact & Trauma Surveillance Study (HITSS).

7 Mar 2022

Novel molecular pathway shared by two neurodegenerative disorders discovered

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

28 Feb 2022

The emergence of infectious diseases from the "germ’s eye view”

The study highlighted that the disruption caused by the COVID-19 pandemic has shown that human societies remain ill-prepared and susceptible to novel infectious diseases.

16 Feb 2022

Looking into the long-COVID brain

Neurological issues, ranging from memory lapses to trouble with attention, have been widely reported after recovery from severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection. Unfortunately, there is limited information about pathways to recovery after severe COVID hospitalization. Now, a prospective study of 4,491 patients hospitalized with COVID suggests neurological recovery can take at least a year. The study is currently available on the medRxiv* preprint while awaiting peer review.

13 Feb 2022

Liver cirrhosis has higher hospitalization and in-hospital mortality rates in Germany

In Germany, liver cirrhosis has the highest mortality rate of any chronic disease requiring hospital admission. When diagnosed as a comorbidity of other chronic diseases, liver cirrhosis at least doubles the mortality rate.

12 Feb 2022

Hazards of persistent and new clinical sequelae caused by SARS-CoV-2 infection among elderly patients

A new study estimated the risk and hazards of persistent and new clinical sequelae of the SARS-CoV-2 infection among elderly patients (above 65 years or older) during the post-acute phase of the infection.

11 Feb 2022

Patients undergoing neurosurgical operations with concomitant COVID-19 infection have higher rates of perioperative complications

This unique paper compares neurosurgical patients with COVID-19 for perioperative complications to those without COVID-19.

31 Jan 2022

Beta-amyloid deposits found in young patients with COVID-19

A new study describes the finding that patients of COVID-19 exhibit large amounts of focal β-amyloid deposits in their neocortical tissues.

25 Jan 2022

Neurological complications of the SARS-CoV-2 vaccine

In a study published in the latest issue of the journal Neurological Sciences, a team of researchers described a three-patient case series presenting with neurological manifestations after the coronavirus disease 2019 (COVID-19) vaccination, followed by a literature review, to propose hypotheses on how neurological symptoms might develop after vaccination.

24 Jan 2022

The long-term neurologic consequences of COVID-19

A team of researchers recently provided insights into central nervous system consequences of the coronavirus disease 2019 (COVID-19) in a perspective paper published in the Science journal.

24 Jan 2022

Study highlights the neurologic manifestations linked with COVID-19 in hospitalized children

Of hospitalized children who tested or were presumed positive for SARS-CoV-2, 44% developed neurological symptoms, and these kids were more likely to require intensive care than their peers who didn't experience such symptoms, according to a new study led by a pediatrician-scientist at UPMC and the University of Pittsburgh School of Medicine.

22 Jan 2022

Researchers uncover new findings about the role of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons.

20 Jan 2022

Study shows inequalities in addressing post-acute neurological manifestations of COVID-19

Researchers have explored the inequities in understanding and addressing the neurological complications of COVID-19 among marginalized communities in the United States.

19 Jan 2022