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Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013

Case report reveals that sugar substitutes may adversely affect endocrine health

It's a known fact that drinking too many sugary drinks can lead to obesity and diabetes, but sugar substitutes may adversely affect your endocrine health, according to a case report presented at the American Association of Clinical Endocrinologists 22nd Annual Scientific and Clinical Congress.

4 May 2013

New findings to benefit women with oestrogen-receptor positive breast cancer

A new analysis has provided a comprehensive comparison of scores designed to predict which women with oestrogen-receptor positive breast cancer are at high risk of recurrence beyond five years after diagnosis, and may benefit from prolonged endocrine treatment.

3 May 2013

Better individual risk prediction for women with breast cancer is getting nearer, says study author

A test that measures the expression levels of 58 genes in oestrogen receptor-positive breast cancers can effectively differentiate between patients who are at higher and lower risk for having their cancer recur elsewhere in the body more than five years after diagnosis, researchers report.

3 May 2013

Prosigna Breast Cancer Prognostic Gene Signature Assay predicts ROR in women with early-stage breast cancer

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and molecular diagnostic products, today announced results from two studies that are featured in oral presentations this week at IMPAKT Breast Cancer Conference.

2 May 2013

Researchers identify gene variations linked to male and female infertility

Identification of genetic variations in the genes coding for the hormone FSH may provide new treatments for male and female infertility, according to work presented at the European Congress of Endocrinology in Copenhagen.

30 Apr 2013

Scientists call for global action against the use of synthetics chemicals in consumer products and pesticides

Today, a group of influential scientists called for swift action by the UN system to prevent harm from a wide variety of synthetic chemicals in consumer products and pesticides that play a role in increased incidences of reproductive diseases, cancer, obesity, and type-2 diabetes worldwide.

26 Apr 2013

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1).

25 Apr 2013

Study examines link between cognitive complaints and neuropsychological testing abnormalities in breast cancer patients

For many years, breast cancer patients have reported experiencing difficulties with memory, concentration and other cognitive functions following cancer treatment. Whether this mental "fogginess" is psychosomatic or reflects underlying changes in brain function has been a bone of contention among scientists and physicians.

20 Apr 2013

AACE publishes comprehensive diabetes management algorithm to treat prediabetes, T2DM patients

The American Association of Clinical Endocrinologists today announced the publication of its comprehensive diabetes management algorithm created to guide primary care physicians, endocrinologists and other health care professionals in the treatment of prediabetes and type 2 diabetes mellitus patients.

20 Apr 2013

University of Florence professor awarded ESCEO-IOF Servier Pierre D. Delmas Prize

Today, at the opening of the European Congress on Osteoporosis & Osteoarthritis in Rome, Italy, Professor Maria Luisa Brandi MD, Professor of Endocrinology and Metabolic Diseases at the University of Florence, Florence, Italy was presented with ESCEO-IOF Servier Pierre D. Delmas Prize.

18 Apr 2013

ATSP-9172 exhibits on-target binding activity in human prostate cancer model

Aileron Therapeutics, Inc. today announced new preclinical data demonstrating that ATSP-9172, its Stapled Peptide inhibitor of HIF-1α-dependent transcription, exhibits on-target binding activity, favorable pharmacokinetic properties and potent in vivo efficacy in a human prostate cancer model.

12 Apr 2013

Method used in aeronautics may help improve safety of plastic food packaging

To prevent molecules migrating from plastic packaging into the food they contain, scientists are identifying each critical point where this phenomenon can occur, using a method inspired from aeronautics.

11 Apr 2013

Orthopaedic surgeons should recommend weight loss to patients prior to joint replacement

The obesity epidemic in America and its impact on musculoskeletal health, as well as related treatment outcomes and costs, was discussed during the AAOS Now forum, "Obesity, Orthopaedics and Outcomes," at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons at McCormick Place in Chicago.

11 Apr 2013

Researchers say testing for BRAF V600E-positive tumors needed for aggressive thyroid cancer

Late stage thyroid cancer patients with aggressive disease may benefit from a genetic test, but experts caution that use of this test in early stage patients is inappropriate because it is unlikely to lead to better outcomes.

11 Apr 2013

BRAF genetic mutation increases mortality among patients with papillary thyroid cancer

Presence of the genetic mutation BRAF V600E was significantly associated with increased cancer-related death among patients with papillary thyroid cancer (PTC); however, because overall mortality in PTC is low and the association was not independent of tumor characteristics, how to use this information to manage mortality risk in patients with PTC is unclear, according to a study in the April 10 issue of JAMA, a Genomics theme issue.

10 Apr 2013

New study shows some women don't stick to recommended treatment for breast cancer

One-quarter of women who should take hormone-blocking therapies as part of their breast cancer treatment either do not start or do not complete the five-year course, according to a new study led by University of Michigan Comprehensive Cancer Center researchers.

10 Apr 2013

American Cancer Society announces new research, training grants for fiscal year 2013

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 175 national research and training grants totaling $79,073,250 for fiscal year 2013.

9 Apr 2013

Updated guidelines for metabolic and bariatric surgery

Significant new scientific evidence published over the last four years has prompted three major medical societies to change its guidance on who should get metabolic and bariatric surgery and which methods should be used.

6 Apr 2013

Exposure to multiple estrogen-mimicking chemicals distorts hormone action

For years, scientists have been concerned about chemicals in the environment that mimic the estrogens found in the body. In study after study, researchers have found links between these "xenoestrogens" and such problems as decreased sperm viability, ovarian dysfunction, neurodevelopmental deficits and obesity.

29 Mar 2013

Endocrine News and Research

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Case report reveals that sugar substitutes may adversely affect endocrine health

New findings to benefit women with oestrogen-receptor positive breast cancer

Better individual risk prediction for women with breast cancer is getting nearer, says study author

Prosigna Breast Cancer Prognostic Gene Signature Assay predicts ROR in women with early-stage breast cancer

Researchers identify gene variations linked to male and female infertility

Scientists call for global action against the use of synthetics chemicals in consumer products and pesticides

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

Study examines link between cognitive complaints and neuropsychological testing abnormalities in breast cancer patients

AACE publishes comprehensive diabetes management algorithm to treat prediabetes, T2DM patients

University of Florence professor awarded ESCEO-IOF Servier Pierre D. Delmas Prize

ATSP-9172 exhibits on-target binding activity in human prostate cancer model

Method used in aeronautics may help improve safety of plastic food packaging

Orthopaedic surgeons should recommend weight loss to patients prior to joint replacement

Researchers say testing for BRAF V600E-positive tumors needed for aggressive thyroid cancer

BRAF genetic mutation increases mortality among patients with papillary thyroid cancer

New study shows some women don't stick to recommended treatment for breast cancer

American Cancer Society announces new research, training grants for fiscal year 2013

Updated guidelines for metabolic and bariatric surgery

Exposure to multiple estrogen-mimicking chemicals distorts hormone action

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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