Endonuclease News and Research

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Rapid miRNA detection with one-pot isothermal rolling circle amplification

This study is led by Professor Jue Ruan (Chinese Academy of Agricultural Sciences, Shenzhen, China). The authors developed a one-pot isothermal detection method based on rolling circle amplification (RCA) for rapid and specific detection of miRNAs and short RNA fragments.

29 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Innovative Subak tool offers affordable solution for detecting nuclease digestion

A new tool could reduce costs for diagnosing infectious diseases.

27 Feb 2024

Researchers identify a new approach to controlling bacterial infections

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections.

7 Feb 2024

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Study examines health impacts of second-hand cigarette smoke exposure

In a recent study, researchers evaluated the effects of chronic second-hand smoke exposure on cognition, behavior, neuropathology, and metabolism.

29 Aug 2023

Cryo-EM reveals structure of key enzyme involved in protein production

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

13 Jul 2023

How New Genomic Techniques can make agricultural production more sustainable

The EU Commission announced the release of a draft proposal for a reformed regulation of New Genomic Techniques (NGTs) that is expected to be published in early July 2023.

29 Jun 2023

First programmable RNA-guided system found in eukaryotes

A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes -; organisms that include fungi, plants, and animals.

28 Jun 2023

North American arrival of A(H5N1) influenza raises concerns of potential pandemic outbreak

Rapid global expansion of highly pathogenic avian influenza A(H5N1) viruses in 2021, including reassortment with North American strains, highlights the need for proactive measures to combat their spread and mitigate the risk of a potential pandemic originating from these reassortants.

31 May 2023

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

28 Feb 2023

UCI-led study uncovers how APOBEC3B protein could protect cells against RNA viruses

A new University of California, Irvine-led study uncovers how a protein, APOBEC3B, could protect cells against many different types of RNA viruses like respiratory syncytial virus (RSV), SARS-CoV2, influenza virus, poliovirus and measles, helping to prevent disease.

22 Feb 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Investigating the evidence of synthetic origins of SARS-CoV-2

Researchers investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated naturally from an animal-to-human spillover or synthetically during coronavirus research experiments.

24 Oct 2022

Study finds telomeres can set damage thresholds for cancer cells above which they cannot continue to divide

A recent study hypothesized that ALT might compromise telomere integrity if not restricted appropriately.

21 Sep 2022

CRISPR-based diagnostics for SARS-CoV-2 detection

In a recent study posted to the Journal of Biochemical and Molecular Toxicology, researchers reviewed clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostics for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jun 2022

Characterizing SARS-CoV-2 non-structural protein 15 endoribonuclease variants

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Researchers revealed that native FokI relaxation might be induced, resulting in FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids.

27 Apr 2022