Endothelial cell News and Research

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Printed human organs!

Each year, pharmaceutical companies invest millions of dollars to test drugs, many of which will never reach the market because of side effects found only during human clinical trials.

6 Nov 2007

Effects of weight gain and subsequent weight loss on endothelial function

When lean healthy young adults gained about 9 pounds, the functioning of their blood vessel lining became impaired -- but shedding the weight restored proper functioning, according to a Mayo Clinic research report.

6 Nov 2007

Immune cells found to promote formation of new blood vessels - potential for endometriosis treatments

A discovery in mice of immune cells that promote the formation of new blood vessels could lead to new treatments for endometriosis, a painful condition associated with infertility that affects up to 15 percent of women of reproductive age.

19 Oct 2007

Important insights into blood vessel formation

Researchers have identified a molecular pathway that plays a critical role in the growth of blood vessels.

15 Oct 2007

Fraunhofer pharmaceutical agent speeds drug development

It takes a great deal of time and money to develop a new drug. At Biotechnica in Hanover from October 9 to 11, the Fraunhofer Life Sciences Alliance will demonstrate how a pharmaceutical agent can make its way more quickly from the research laboratory to the pharmacy.

8 Oct 2007

Depression, aging, and proteins made by a virus may all play role in heart disease

Researchers here have linked an increase in two immune system proteins essential for inflammation to a latent viral infection and proposed a chain of events that might accelerate cardiovascular disease.

2 Oct 2007

Origin of the mammalian lymphatic vasculature

In the October 1 issue of G&D, Dr. Guillermo Oliver (St. Jude Children's Research Hospital) and colleagues present new evidence to resolve a century-old debate over the origin of the mammalian lymphatic vasculature.

1 Oct 2007

DNA damage response confers a barrier for viral tumorigenesis

Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma (KS).

27 Sep 2007

Researchers uncover likely source of rejection for otherwise well-matched kidney transplants

UT Southwestern Medical Center researchers, collaborating with colleagues in Germany, have for the first time identified antibodies associated with transplant rejection of otherwise healthy kidneys.

27 Sep 2007

Testes offer a promising new source of stem cells

After a decade of research, Howard Hughes Medical Institute scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue.

20 Sep 2007

3-D Petri dish that grows cells in three dimensions

A team of Brown University biomedical engineers has invented a 3-D Petri dish that can grow cells in three dimensions, a method that promises to quickly and cheaply produce more realistic cells for drug development and tissue transplantation.

20 Sep 2007

Living, growing artificial heart-valve replacements for children

Infants and children receiving artificial heart-valve replacements face several repeat operations as they grow, since the since the replacements become too small and must be traded for bigger ones.

13 Sep 2007

Radiation and drug combo helps boost efficacy of lung-cancer treatment

Combining radiation therapy with a drug that helps destroy blood vessels nourishing malignant tumors has been shown in mice to be significantly more effective in treating lung cancer than either approach alone, researchers at UT Southwestern Medical Center have found.

5 Sep 2007

Myoendothelial cells identified as new human source of stem cells with potential to repair muscle

For the first time, scientists at Children's Hospital of Pittsburgh of UPMC have discovered a unique population of adult stem cells derived from human muscle that could be used to treat muscle injuries and diseases such as heart attack and muscular dystrophy.

5 Sep 2007

Radiation and drug combo helps boost efficacy of lung cancer treatment

3 Sep 2007

Does physical activity provide a molecular key to longevity?

Fitness and physical exercise are among the most neglected means to improve prognosis. They are the healthiest cardiovascular intervention. Even cardiologists focus on pharmacological treatment and evaluate classical risk factors without asking about daily exercise or objective measures of physical capacity. It is surprising considering the strong data that underscores the survival benefit of regular exercise training.

2 Sep 2007

Pancreatic cancer fights off immune attack

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum) and the Heidelberg University Hospitals have discovered that pancreatic cancer attracts regulatory T cells, which suppress the activity of immune cells.

30 Aug 2007

Big leap in genomic screening of blood vessels from patient tissue

Scientists have developed a new method of capturing a complete genome-wide screening of blood vessel cells in their actual disease state, advancing the potential for genetic research on the tissue responsible for delivering nourishment that can accelerate the growth of both a cancer tumor or wound healing.

30 Aug 2007

Geron demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction

Geron Corporation has reported its scientists and collaborators have demonstrated that human embryonic stem cell (hESC)-derived cardiomyocytes improve heart function when transplanted after myocardial infarction.

28 Aug 2007

Australian researchers discover a 'novel molecular dictator with a conscience'

University of New South Wales (UNSW) researchers have uncovered an important naturally occurring mechanism in the body where "bad" cells that cause blockages in our blood vessels are kept under strict growth control, while "good" cells that keep our blood vessels free of clots and growths are left unaffected.

27 Aug 2007