Endothelial cell News and Research

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Arteries bio-engineered from elderly cells

Researchers from Duke University's Medical Center and Pratt School of Engineering have demonstrated that they can grow new human blood vessels from cells taken from patients who especially need such assistance – older adults with cardiovascular disease.

14 Jun 2005

Antibody combined with cancer drug shows promise against breast tumors

An antibody that targets the blood vessels nourishing tumors significantly reduced breast cancer formation and growth in mice when combined with a current cancer drug, according to researchers at UT Southwestern Medical Center.

16 May 2005

Counting number of endothelial cells in blood may predict cancer treatment's effectiveness

Counting the amount of a type of normal cell circulating in the blood of people with cancer could predict whether a tumor progresses or responds to therapy, a new study led by the University of Michigan Comprehensive Cancer Center has found. The finding could give doctors an early indication of whether a treatment will be successful, sparing patients months of an ineffective therapy.

15 May 2005

Critical lock and key mechanism found for the assembly of tumor blood vessels

A critical lock and key mechanism that allows the final step in the completion of new blood vessel formation has been identified by a University of California, San Diego (UCSD) School of Medicine team in research that promises to lead to a new way to halt tumor growth by cutting off the tumor blood supply.

3 May 2005

Simvastatin linked to protection against endothelial dysfunction in diabetic rats

Almost two years ago, the diabetes arm of the Heart Protection Study, the largest-ever study using a cholesterol-lowering medication, found that diabetics who took a daily dose of the statin drug simvastatin over five years reduced the risk of a first nonlethal heart attack by 37 percent and risk of a first nonfatal or fatal stroke by 24 percent, regardless of their cholesterol or glucose levels.

3 Apr 2005

Pomegranate juice helps keep fatty deposits from collecting on artery walls

A study in the current issue of the Proceedings of the National Academy of Sciences, by Italian and American scientists reports that pomegranate juice helped keep fatty deposits from collecting on artery walls in mice, and kept human heart cells healthier. The mice were specially bred to have high cholesterol and on human heart cells in culture.

22 Mar 2005

Link between C-reactive protein, heart disease and stroke

The cells that line the arteries are able to produce C-reactive protein, according to a study funded by the National Institutes of Health and published in the April issue of American Journal of Pathology.

16 Mar 2005

Study indicates need for new standards and training for cornea transplants

Improving the training and standardizing the procedures used by the nation's eye banks to assess corneal cells may help to select corneas with optimal health for transplantation, according to new study led by Jonathan H. Lass, MD, principal investigator of the study and chairman of the Department of Ophthalmology at University Hospitals of Cleveland and Case Western Reserve University School of Medicine.

14 Mar 2005

New way of transporting medicines into the brain

Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it penetrates the brain.

13 Feb 2005

Gene therapy for heart patients with chest pains who do not benefit from other treatments

Individuals with moderate to severe chest pains (angina) who have not found relief from medication may benefit from a new gene therapy approach being used by cardiologists at Rush University Medical Center to grow new blood vessels in the heart.

3 Feb 2005

Research leads to new antiangiogenic drugs

Scientists have uncovered critical information that may lead to an urgently needed method for effective monitoring of antiangiogenic cancer therapies.

17 Jan 2005

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Cell biologists are of two minds about the possible biological effects of mobile phone radiation. In the mid-1990s, studies describing possible pathological effects on tissues bombarded with low-level radio frequencies (RF) were first featured in the popular press and then discredited by scientists.

4 Dec 2004

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

Heart bypass gets new source for replacement blood vessels

The search for a stable, renewable source of blood vessels, especially for potential use in heart bypass surgery, has reached a milestone at the State University of New York at Buffalo.

11 Nov 2004

Protein important to nerve development serves the dual purpose of stimulating the growth of blood vessels

The discovery opens the possibility that blood vessel growth (angiogenesis) one day may be induced, or stymied, for therapeutic use against heart disease, cancer, and other illnesses, according to Dean Y. Li, M.D., Ph.D., associate professor of internal medicine in the U of U School of Medicine's Division of Cardiology.

1 Nov 2004

Researchers are one step closer to understanding how blood cells develop through the use of human embryonic stem cells

This process is also significant because the blood cells were developed without the use of animal serum, which was previously thought to be essential for blood cell development. Instead, specific growth factors are added to guide the cell differentiation.

1 Nov 2004

Impaired endothelial function is an early indicator of atherosclerosis

Impaired endothelial function is an early indicator of atherosclerosis according to a study of healthy people followed from childhood to young adulthood reported in Circulation: Journal of the American Heart Association.

25 Oct 2004

Potential new treatment strategy against metastatic cancer cells

A team of scientists at The Scripps Research Institute has identified a potential treatment strategy against metastatic cancer cells that has never been tried before.

25 Oct 2004

Breakthrough discovery in treating narrowed arteries

A breakthrough discovery by Heart and Stroke Foundation researcher Dr. Michael Kutryk that harnesses the body’s own natural defenses to fight narrowing of the arteries has been recognized as “a glimpse into the future” and “potentially one of the biggest advances in cardiology to date”.

25 Oct 2004

Researchers discover mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells

Northwestern University researchers have discovered a mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells, but not on insidious, aggressive melanoma cells that masquerade as endothelial-like cells by forming their own vascular networks, called "vasculogenic mimicry."

8 Oct 2004

Endothelial cell News and Research

Arteries bio-engineered from elderly cells

Antibody combined with cancer drug shows promise against breast tumors

Counting number of endothelial cells in blood may predict cancer treatment's effectiveness

Critical lock and key mechanism found for the assembly of tumor blood vessels

Simvastatin linked to protection against endothelial dysfunction in diabetic rats

Pomegranate juice helps keep fatty deposits from collecting on artery walls

Link between C-reactive protein, heart disease and stroke

Study indicates need for new standards and training for cornea transplants

New way of transporting medicines into the brain

Gene therapy for heart patients with chest pains who do not benefit from other treatments

Research leads to new antiangiogenic drugs

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Heart bypass gets new source for replacement blood vessels

Protein important to nerve development serves the dual purpose of stimulating the growth of blood vessels

Researchers are one step closer to understanding how blood cells develop through the use of human embryonic stem cells

Impaired endothelial function is an early indicator of atherosclerosis

Potential new treatment strategy against metastatic cancer cells

Breakthrough discovery in treating narrowed arteries

Researchers discover mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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