Endothelin News and Research

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Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.
Long-term effects of synthetic progestins cause for concern

Long-term effects of synthetic progestins cause for concern

Study aims to improve treatment for children born with heart defects

Study aims to improve treatment for children born with heart defects

Tezosentan does not appear to improve symptoms for patients with acute heart failure

Tezosentan does not appear to improve symptoms for patients with acute heart failure

Survival data presented from phase II study of hormone-resistant prostate cancer patients

Survival data presented from phase II study of hormone-resistant prostate cancer patients

New AstraZeneca compound shows promoise for hormone resistant prostate cancer patients with bone metastases

New AstraZeneca compound shows promoise for hormone resistant prostate cancer patients with bone metastases

Twin studies identify genes that influence human health in unexpected ways

Twin studies identify genes that influence human health in unexpected ways

Pharmacopeia announces positive results in hypertension and diabetic nephropathy trial

Pharmacopeia announces positive results in hypertension and diabetic nephropathy trial

Old red wines best for a healthy heart

Old red wines best for a healthy heart

PR Pharmaceuticals issued U.S. patent covering 2-methoxyestradiol for the treatment of diabetes

PR Pharmaceuticals issued U.S. patent covering 2-methoxyestradiol for the treatment of diabetes

New drug to treat stroke complications tested in US for the first time as part of an international trial

New drug to treat stroke complications tested in US for the first time as part of an international trial

Myogen's Ambrisentan granted orphan drug designation by Europeans

Myogen's Ambrisentan granted orphan drug designation by Europeans

Cells linked to asthma and eczema also help cure deadly illness in mice

Cells linked to asthma and eczema also help cure deadly illness in mice

Mast cells can provide protection from a potentially deadly condition known as sepsis

Mast cells can provide protection from a potentially deadly condition known as sepsis

Investigational drug for pulmonary hypertension may improve the quality of life for patients with scleroderma and lupus

Investigational drug for pulmonary hypertension may improve the quality of life for patients with scleroderma and lupus

A revolutionary approach to angiogenesis could make cancer treatment more effective at killing tumours

A revolutionary approach to angiogenesis could make cancer treatment more effective at killing tumours

Study suggests that patients with pulmonary arterial hypertension may benefit from Thelin therapy

Study suggests that patients with pulmonary arterial hypertension may benefit from Thelin therapy

FDA has granted orphan drug designation to Myogen's ambrisentan, for the treatment of pulmonary arterial hypertension

FDA has granted orphan drug designation to Myogen's ambrisentan, for the treatment of pulmonary arterial hypertension

Atrasentan reduces cancer risk by 20 percent in men with advanced hormone-resistant prostate cancer

Atrasentan reduces cancer risk by 20 percent in men with advanced hormone-resistant prostate cancer

Crucial discovery may help better diagnose and treat children with Hirschsprung disease

Crucial discovery may help better diagnose and treat children with Hirschsprung disease

Oral sildenafil improved exercise tolerance, cardiac output and quality of life in 22 patients with primary pulmonary hypertension

Oral sildenafil improved exercise tolerance, cardiac output and quality of life in 22 patients with primary pulmonary hypertension