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Teaming broccoli with sprouts may make vegetable's anti-cancer effect twice as powerful

A new University of Illinois study provides convincing evidence that the way you prepare and consume your broccoli matters, and also suggests that teaming broccoli with broccoli sprouts may make the vegetable's anti-cancer effect almost twice as powerful.

28 Jan 2011

Discovery of aldose reductase enzyme can result in new therapies for asthma and COPD

Researchers have proved that a single "master switch" enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease.

28 Jan 2011

Scientist identifies polymorphism that raises risk of poor outcomes in preterm infants

Researchers at Cincinnati Children's Hospital Medical Center have identified biomarkers of poor outcomes in preterm infants that may help identify new approaches to prevention.

28 Jan 2011

Aging-associated protein deficiency may lead to positive breast cancer in women

The most common type of breast cancer in older women - estrogen and progesterone receptor positive breast cancer - has been linked to a protein that fends off aging-related cellular damage.

28 Jan 2011

SRI awarded DOE grant to expand MetaCyc database and enhance Pathway Tools software

SRI International, an independent nonprofit research and development organization, announced today it has been awarded a grant by the Department of Energy (DOE) to expand its MetaCyc database and enhance its Pathway Tools software. This project will give SRI's bioinformatics tools even greater utility in the emerging area of bioenergy, or renewable energy derived from biological sources.

27 Jan 2011

Targeting UROD enzyme boosts effects of radiotherapy and chemotherapy in head, neck tumors

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer.

27 Jan 2011

Researchers develop anti-HIV gene therapy for rendering T-cells resistant to infection

An innovative genetic strategy for rendering T-cells resistant to HIV infection without affecting their normal growth and activity is described in a paper published in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. The paper is available free online.

26 Jan 2011

Scientists to develop enzyme that protects against nerve agents

Protection against nerve gas attack is a significant component of the defense system of many countries around the world. Nerve gases are used by armies and terrorist organizations, and constitute a threat to both the military and civilian populations, but existing drug solutions against them have limited efficiency.

25 Jan 2011

Researchers reveal how genetic mutation contributes to cancer development

Scientists around the world have been hot on the trail of a genetic mutation closely associated with some brain cancers and leukemia since the mutation's discovery in 2008. The hunt is now yielding fruit. In the Jan. 18, 2011 issue of Cancer Cell, researchers reveal how the mutation contributes to cancer development and suggest potential ways to counter its effects.

21 Jan 2011

Acetylation complex fits like a halo over a histone

To understand the emerging science of epigenetics-a field that describes how genes may be regulated without altering the underlying DNA itself-scientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells.

21 Jan 2011

Sunshine and Binghamton University enter research agreement for cancer compound

Sunshine Biopharma, Inc. a development stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has executed an agreement with The Research Foundation of the State University of New York (SUNY), acting for and on behalf of Binghamton University (Binghamton, NY).

21 Jan 2011

Scientists find ADAR1 enzyme protect against measles virus

Scientists at The Scripps Research Institute have found that a known enzyme in cells protects against measles virus, likely by altering the virus's genetic material, RNA. Cells lacking the enzyme become highly vulnerable to the virus's destructive effects. The enzyme also protects against several other respiratory viruses, including influenza A.

21 Jan 2011

4SC initiates dosing in resminostat Phase I/II SHORE study for KRAS-mutant colorectal cancer

4SC AG, a drug discovery and development company, today announced that the first patient has been dosed in the Phase I/II SHORE study with the oral pan-histone deacetylase (HDAC) inhibitor resminostat as a second-line treatment for patients with advanced and metastatic colorectal KRAS-mutant cancer.

20 Jan 2011

Findings could speed use of RNA nanotechnology for treating disease

Scientists are reporting an advance in overcoming a major barrier to the use of the genetic material RNA in nanotechnology - the field that involves building machines thousands of times smaller than the width of a human hair and now is dominated by its cousin, DNA. Their findings, which could speed the use of RNA nanotechnology for treating disease, appear in the monthly journal ACS Nano.

20 Jan 2011

Biomarin commences BMN 701 Phase 1/2 trial for treatment of Pompe disease

BioMarin Pharmaceutical Inc. announced today that it has initiated a Phase 1/2 trial for BMN 701, a novel fusion protein of insulin-like growth factor 2 and acid alpha glucosidase in development for the treatment of Pompe disease.

20 Jan 2011

Salk Institute uncovers presenilin's productive side

Mutant presenilin is infamous for its role in the most aggressive form of Alzheimer's disease-early-onset familial Alzheimer's-which can strike people as early as their 30s. In their latest study, researchers at the Salk Institute uncovered presenilin's productive side: It helps embryonic motor neurons navigate the maze of chemical cues that pull, push and hem them in on their way to their proper targets.

19 Jan 2011

UNC scientists discover how chaperone enzyme plays a key role in cells' ability to tolerate DNA damage

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases.

19 Jan 2011

Loyola offers new, nonsurgical treatment for Dupuytren's contracture

Loyola University Health System is among the first centers to offer a new, nonsurgical treatment for Dupuytren's contracture, a debilitating condition that curls fingers toward the palm.

19 Jan 2011

RG7204 Phase III study shows significant survival benefit in patients with metastatic melanoma

Genentech, a member of the Roche Group, today announced that BRIM3, a Phase III clinical study of RG7204, met its co-primary endpoints showing a significant survival benefit in people with previously untreated BRAF V600 mutation-positive metastatic melanoma.

19 Jan 2011

Study may help develop novel ways to combat lipotoxic cardiomyopathy, related heart disease

A team led by Rolf Bodmer, Ph.D. at Sanford-Burnham Medical Research Institute recently unraveled an alternative pathway to lipotoxic cardiomyopathy in fruit flies - a genetic mechanism that occurs independently of a diet high in fat.

19 Jan 2011

Enzyme News and Research

Teaming broccoli with sprouts may make vegetable's anti-cancer effect twice as powerful

Discovery of aldose reductase enzyme can result in new therapies for asthma and COPD

Scientist identifies polymorphism that raises risk of poor outcomes in preterm infants

Aging-associated protein deficiency may lead to positive breast cancer in women

SRI awarded DOE grant to expand MetaCyc database and enhance Pathway Tools software

Targeting UROD enzyme boosts effects of radiotherapy and chemotherapy in head, neck tumors

Researchers develop anti-HIV gene therapy for rendering T-cells resistant to infection

Scientists to develop enzyme that protects against nerve agents

Researchers reveal how genetic mutation contributes to cancer development

Acetylation complex fits like a halo over a histone

Sunshine and Binghamton University enter research agreement for cancer compound

Scientists find ADAR1 enzyme protect against measles virus

4SC initiates dosing in resminostat Phase I/II SHORE study for KRAS-mutant colorectal cancer

Findings could speed use of RNA nanotechnology for treating disease

Biomarin commences BMN 701 Phase 1/2 trial for treatment of Pompe disease

Salk Institute uncovers presenilin's productive side

UNC scientists discover how chaperone enzyme plays a key role in cells' ability to tolerate DNA damage

Loyola offers new, nonsurgical treatment for Dupuytren's contracture

RG7204 Phase III study shows significant survival benefit in patients with metastatic melanoma

Study may help develop novel ways to combat lipotoxic cardiomyopathy, related heart disease

Biochemistry eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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