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Lipoxin A4 regulates bronchial epithelial cell responses to acid injury

Doctors are gaining new leverage in the fight against lung injury caused by acid reflux. The paper by Bonnans et al., "Lipoxin A4 regulates bronchial epithelial cell responses to acid injury," appears in the April issue of The American Journal of Pathology and is accompanied by a commentary.

3 May 2006

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

3 May 2006

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

The discovery of a gene, called PRDM1, as a tumor suppressor sheds new light on the cause - and possible treatment - of diffuse large B-cell lymphomas (DLBCLs), a cancer of the blood's B-lymphocytes. DLBCLs comprise about 30 percent of non-Hodgkin's lymphomas.

25 Apr 2006

Kidney treatments may be improved with new understanding of cell death mechanism

Finding how two proteins conspire to get kidney cells to self-destruct when oxygen supplies are low may one day improve dismal mortality rates for ischemic renal failure, researchers say.

23 Apr 2006

New finding provides researchers with renewable source for macrophages and neutrophils

A new approach to generating large quantities of two types of white blood cells that are critical for destroying invading bacteria, viruses and other pathogens in humans has been developed by researchers at the University of California, San Diego (UCSD) School of Medicine.

19 Apr 2006

Lack of response to herceptin may be reversed with PI3K inhibiting agents

Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at the University of Texas M. D. Anderson Cancer Center.

11 Apr 2006

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

The unchecked activity of a cell signaling pathway crucial in embryonic development and the liver's response to injury leads to liver cancer, researchers from Duke University Medical Center and John Hopkins University School of Medicine have found.

4 Apr 2006

Weill Cornell researchers identify tumor-suppressor gene important to diffuse large B-cell lymphomas

Inactivation of a "tumor suppressor" gene could be a major cause of a class of blood cancers called diffuse large B-cell lymphomas, reports a team of researchers at the Weill Medical College of Cornell University.

30 Mar 2006

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

Researchers at the University of Pennsylvania School of Medicine have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually sequesters melanin, the dark pigment found in skin, hair, and eyes.

28 Mar 2006

Potential therapeutic targets against serious side effects of smallpox vaccine

Smallpox is considered a potential terrorist weapon, but millions of people in the United States are currently advised not to get a vaccine to the disease because they are susceptible to developing a severe adverse reaction.

23 Mar 2006

Ginseng may improve survival and quality of life after a diagnosis of breast cancer

Ginseng, one of the most widely used herbs in traditional Chinese medicine, may improve survival and quality of life after a diagnosis of breast cancer, according to a recent study by Vanderbilt-Ingram Cancer Center researchers.

19 Mar 2006

Hormone C-type natriuretic peptide protects the heart muscle from thickening abnormally

When the heart is weakened, it tries to compensate for its impaired pumping function through an enlargement of the heart muscle cells. Physicians speak in this case of cardiac hypertrophy, abnormal enlargement of the heart.

13 Mar 2006

Scientists create new type of 'bio-gel'

Scientists at The University of Manchester have created a new type of 'bio-gel' which provides a pH neutral environment for culturing cells in 3D, as published in the journal Advanced Materials.

From The University of Manchester 7 Mar 2006

Fibulins inhibit both tumor growth and blood-vessel formation

Researchers at National Jewish Medical and Research Center report in the March issue of Cancer Research that a pair of promising proteins, known as fibulins 3 and 5, slow the growth of cancer tumors in mice by preventing blood vessels from sprouting. The proteins are promising candidates for use in cancer therapy.

1 Mar 2006

Spinocerebellar ataxia and other neurodegenerative diseases might be treatable with drugs that alter the activity of potassium channels

For the first time, researchers have linked mutations in a gene that regulates how potassium enters cells to a neurodegenerative disease and to another disorder that causes mental retardation and coordination problems.

27 Feb 2006

New tool to discover molecules that can enhance or block different kinds of tastes

Researchers from the Monell Chemical Senses Center have succeeded in growing mature taste receptor cells outside the body and for the first time have been able to successfully keep the cells alive for a prolonged period of time.

27 Feb 2006

New generation gold-based drugs for treating rheumatoid arthritis

Gold compounds have been used for the treatment of rheumatoid arthritis and other autoimmune diseases for more than 75 years, but until now, how the metals work has been a mystery.

27 Feb 2006

New flu vaccine takes weeks to mass produce

Using cell-based methods researchers have developed a commercially viable method for mass producing effective vaccines against potential pandemic influenza strains in weeks instead of the months required for traditional egg-based vaccines.

17 Feb 2006

Discovery of the molecular mechanism that inhibits HCV replication in vitro

Since its discovery several decades ago, the insidious human pathogen has stymied the quest for anti-viral therapies by refusing to reproduce in test tubes for more than a few hours or days, denying scientists an efficient virus production and infection system for experimental research.

7 Feb 2006

Fatty acids such as those found in corn oil turn on genes that stimulate tumor growth

Omega-6 fatty acids--such as those found in corn oil--caused human prostate tumors in cell culture to grow twice as quickly as tumors to which omega-6 fats had not been added, according to a study conducted at the San Francisco VA Medical Center.

5 Feb 2006

Exosomes News and Research

Lipoxin A4 regulates bronchial epithelial cell responses to acid injury

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

Kidney treatments may be improved with new understanding of cell death mechanism

New finding provides researchers with renewable source for macrophages and neutrophils

Lack of response to herceptin may be reversed with PI3K inhibiting agents

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

Weill Cornell researchers identify tumor-suppressor gene important to diffuse large B-cell lymphomas

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

Potential therapeutic targets against serious side effects of smallpox vaccine

Ginseng may improve survival and quality of life after a diagnosis of breast cancer

Hormone C-type natriuretic peptide protects the heart muscle from thickening abnormally

Scientists create new type of 'bio-gel'

Fibulins inhibit both tumor growth and blood-vessel formation

Spinocerebellar ataxia and other neurodegenerative diseases might be treatable with drugs that alter the activity of potassium channels

New tool to discover molecules that can enhance or block different kinds of tastes

New generation gold-based drugs for treating rheumatoid arthritis

New flu vaccine takes weeks to mass produce

Discovery of the molecular mechanism that inhibits HCV replication in vitro

Fatty acids such as those found in corn oil turn on genes that stimulate tumor growth

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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