Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

Johns Hopkins researchers have discovered a previously unrecognized role played by the gene HIF-1 as it helps cell survive when a lack of oxygen decreases production of an energy-rich molecule called ATP and increases production of toxic molecules.

9 Mar 2006

Australian stem cell breakthrough

A University of New South Wales (UNSW) researcher based at the Diabetes Transplant Unit (DTU) at Sydney's Prince of Wales Hospital has produced a human embryonic stem cell (hESC) line without the use of any animal products. The breakthrough eliminates the risk of animal-to-human contamination in potential stem cell therapy treatments.

23 Jan 2006

Fibroblast research could lead to alternatives to implanted electronic pacemakers

In guinea pig experiments, Johns Hopkins scientists fused common connective tissue cells taken from lungs with heart muscle cells to create a safe and effective biological pacemaker whose cells can fire on their own and naturally regulate the muscle's rhythmic beat.

5 Dec 2005

Stem cells to repair heart tissue soon after a heart attack

Stem cells derived from human heart tissue develop into multicellular, spherical structures called cardiospheres that express the normal properties of primitive heart tissue, smooth muscle and blood vessel cells, according to a study by Johns Hopkins researchers.

20 Nov 2005

Biologically engineered blood vessels now an option in cardiac bypass

The first-ever human use of completely biologically engineered blood vessels grown from a person's own cells could be an option for people who have vessels too damaged for heart bypass, researchers reported at the American Heart Association's Scientific Sessions 2005.

16 Nov 2005

New hormone discovery has implications for liver diseases

Researchers at UT Southwestern Medical Center have discovered that the small intestine communicates with the liver to control the production of bile acids - a finding that has great medical implications in treating people at risk for certain types of liver disease.

11 Oct 2005

Newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins

A newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins, such as vitamins A, E, and D, according to a new study in the October 2005 issue of Cell Metabolism.

11 Oct 2005

New method to measure circadian cycles

Everyone knows morning people and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had to rely on prolonged behavioural observation.

27 Sep 2005

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

...a discovery that could pave the way for more effective cancer treatments.

27 Sep 2005

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

Surprising immune system cells discovery

Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells.

26 Sep 2005

Adult human neural stem cells used to successfully regenerate spinal cord tissue

Researchers at the UC Irvine Reeve-Irvine Research Center have used adult human neural stem cells to successfully regenerate damaged spinal cord tissue and improve mobility in mice.

26 Sep 2005

Researchers discover one of the reasons why melanoma is so ruthless

About 60,000 Americans will be diagnosed with melanoma this year, says the American Cancer Society, and 10,000 of those cases will be fatal. If not caught in the early stages, melanoma can be a particularly virulent form of cancer, spreading through the body with an efficiency that few tumors possess.

5 Sep 2005

New technique for creating human embryonic stem cells

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.

22 Aug 2005

Method to propagate mouse brain stem cells derived from ES cells

It's hard to grow stem cells in a dish. In particular, while it is possible to multiply mouse embryonic stem cells in culture, propagating stem cells that are specific to distinct tissues (e.g. neural stem cells) has proven to be a challenge.

16 Aug 2005

Urine testing may predict birthmarks

Vascular anomalies - birthmarks caused by abnormal development of arteries, capillaries, veins or lymph vessels - can sometimes begin to progress, requiring aggressive treatment to save the child's health or vision. Research at Children's Hospital Boston now suggests that urine testing can help monitor these anomalies and predict those about to become a serious threat.

6 Jul 2005

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology.

6 Jul 2005

New complete muscle grown in the lab

A multinational team of researchers has grown new muscle complete with its own network of blood vessels in the laboratory, and implanted the new muscle in a living mouse. The accomplishment is a first for tissue engineering, according to a report in the June 19 issue of Nature Biotechnology.

19 Jun 2005

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

In this week's journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the "holy grail" puzzles of developmental biology: the existence of a mechanism that insures that the exterior of our bodies is symmetrical while inner organs are arranged asymmetrically.

11 May 2005

Discovery may have implications for the treatment of hemophilia A and B

University of North Carolina at Chapel Hill researchers have made a discovery that may have implications for the treatment of liver-based genetic defects such as hemophilia A and B in humans.

15 Feb 2005

Fibroblast News and Research

Further Reading

Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

Australian stem cell breakthrough

Fibroblast research could lead to alternatives to implanted electronic pacemakers

Stem cells to repair heart tissue soon after a heart attack

Biologically engineered blood vessels now an option in cardiac bypass

New hormone discovery has implications for liver diseases

Newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins

New method to measure circadian cycles

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Surprising immune system cells discovery

Adult human neural stem cells used to successfully regenerate spinal cord tissue

Researchers discover one of the reasons why melanoma is so ruthless

New technique for creating human embryonic stem cells

Method to propagate mouse brain stem cells derived from ES cells

Urine testing may predict birthmarks

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

New complete muscle grown in the lab

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

Discovery may have implications for the treatment of hemophilia A and B

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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