Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Vertex reports interim data from VX-809 and KALYDECO combination Phase 2 study for cystic fibrosis

Vertex Pharmaceuticals Incorporated announced today an interim analysis of data from an ongoing Phase 2 study of VX-809 and KALYDECO (ivacaftor) that showed significant improvements in lung function (FEV1) among adults with cystic fibrosis (CF) who have two copies.

7 May 2012

Comorbidities common among patients with COPD

Comorbidities are common among patients with chronic obstructive pulmonary disease (COPD), and a number of these comorbidities are independently associated with an increased mortality risk, according to a new study.

4 May 2012

High fructose intake may increase risk of NFALD in obese people

Obese people who consume increased amounts of fructose, a type of sugar that is found in particular in soft drinks and fruit juices, are at risk for nonalcoholic fatty liver disease (NFALD) and more its more severe forms, fatty inflammation and scarring.

3 May 2012

Biogen Idec first quarter revenues increase 7% to $1.3 billion

Biogen Idec Inc., a global biotechnology leader in the discovery, development, manufacturing and commercialization of innovative therapies, today announced its first quarter 2012 results.

2 May 2012

Couples with infertility and miscarriages offered detailed embryo screening with 99% accuracy

Termed “preimplantation genetic screening (PGS)” the process involves a full chromosome count of embryos to ensure only the healthiest are implanted. It has a 99 per cent accuracy rate, giving hopeful parents the best chance to conceive and carry a healthy baby to term.

30 Apr 2012

Teens with high levels of uric acid at increased risk for high blood pressure

Teens with high levels of uric acid appear to be at increased risk for high blood pressure, according to results of research from scientists at the Johns Hopkins Children's Center.

30 Apr 2012

MR enterography accurate in diagnosing fibrosis in pediatric patients with Crohn disease

MR enterography is superior to CT enterography in diagnosing fibrosis in pediatric patients with Crohn disease and equally as good as CT enterography in detecting active inflammation, and a new study shows.

30 Apr 2012

Bullying, ostracism strong predictors of increased symptoms of depression or anxiety

The challenges that come with battling a chronic medical condition or developmental disability are enough to get a young person down. But being left out, ignored or bullied by their peers is the main reason youths with special health care needs report symptoms of anxiety or depression, according to a study to be presented Sunday, April 29, at the Pediatric Academic Societies (PAS) annual meeting in Boston.

30 Apr 2012

UMKC School of Medicine receives $400,000 gift to establish Pulmonary Fibrosis Research Program

The University of Missouri-Kansas City has received a $400,000 gift to establish a pulmonary fibrosis research program at the UMKC School of Medicine. The gift comes from the estate of the late Mary K. Geldmacher, a retired St. Louis school teacher who suffered from pulmonary fibrosis and passed away in 2009. Pulmonary fibrosis is the formation or development of excess fibrous connective tissue in the lungs, commonly described as “scarring of the lung.”

26 Apr 2012

UT Southwestern lung transplant recipient lives through 19 years

UT Southwestern Medical Center has performed more than 300 lung transplants in recent decades, and Michael Young represents a remarkable success story.

25 Apr 2012

Researchers identify fibronectin strain-sensitive probes

Fibronectin plays a major role in wound healing and embryonic development. The protein, which is located in the extracellular matrix of cells, has also been linked to pathological conditions including cancer and fibrosis.

25 Apr 2012

Severe fibrosis increases early atherosclerosis risk in patients with chronic HCV-1 infection

Italian researchers report that severe fibrosis increases the early atherosclerosis risk in patients with genotype 1 chronic hepatitis C virus (HCV) infection. A second study found that fatty liver disease also increases risk of developing atherosclerosis at an earlier period. Both studies appear in the May issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

25 Apr 2012

Researchers identify gene that increases risk of MI in newborns with CF

Researchers at Johns Hopkins have identified a gene that modifies the risk of newborns with cystic fibrosis (CF) developing neonatal intestinal obstruction, a potentially lethal complication of CF.

24 Apr 2012

Nano-devices cross blood-brain barrier to deliver drug to treat cerebral palsy

A team of scientists from Johns Hopkins and elsewhere have developed nano-devices that successfully cross the brain-blood barrier and deliver a drug that tames brain-damaging inflammation in rabbits with cerebral palsy.

23 Apr 2012

Autophagy potential target for new CF treatments

Scientists have found why a certain type of bacteria, harmless in healthy people, is so deadly to patients with cystic fibrosis.

23 Apr 2012

CRF announces top 10 clinical research achievement awards

Ten outstanding clinical research projects from institutions around the country have been selected to receive the inaugural Clinical Research Forum Top 10 Clinical Research Achievement Awards. The winning projects are compelling examples of the scientific innovation that results from the nation's investment in clinical research that can benefit human health and welfare.

19 Apr 2012

UM hosts symposium on next generation characterization tools for therapeutic proteins

In a concerted effort to boost regional collaboration on developing new protein drug and diagnostics, the University of Maryland (UM) School of Pharmacy has hosted the first Interdisciplinary Symposium on Next Generation Characterization Tools for Therapeutic Proteins.

16 Apr 2012

Longer looks: Diagnosing autism in minutes; Finding new uses for old drugs; Cancer war victories

Autism is an extremely complex diagnosis. Parental insight, physician observations and hours of data can factor into determining whether a child actually has the condition or is just a little on the quirky side. Now a Harvard researcher, Dennis P. Wall, has published research about a Web-based tool he developed that promises to diagnose autism in minutes, not hours -;

12 Apr 2012

CLYD gene serves as crucial negative regulator in pulmonary fibrosis

An international team of researchers led by Georgia State University scientists have found a key component in the pathological process of pulmonary fibrosis, a fatal disease for which there is currently no cure.

11 Apr 2012

CPF proclaims September as 'Pulmonary Fibrosis Awareness Month'

The Coalition for Pulmonary Fibrosis (CPF) announced today the month of September 2012 will be proclaimed "Pulmonary Fibrosis Awareness Month." In previous years, the CPF has celebrated "National Pulmonary Fibrosis Awareness Week" for one week each September, but expanding the time frame to a month will help achieve greater national awareness and fundraising in the race to find treatment and a cure.

7 Apr 2012

Fibrosis News and Research

Further Reading

Vertex reports interim data from VX-809 and KALYDECO combination Phase 2 study for cystic fibrosis

Comorbidities common among patients with COPD

High fructose intake may increase risk of NFALD in obese people

Biogen Idec first quarter revenues increase 7% to $1.3 billion

Couples with infertility and miscarriages offered detailed embryo screening with 99% accuracy

Teens with high levels of uric acid at increased risk for high blood pressure

MR enterography accurate in diagnosing fibrosis in pediatric patients with Crohn disease

Bullying, ostracism strong predictors of increased symptoms of depression or anxiety

UMKC School of Medicine receives $400,000 gift to establish Pulmonary Fibrosis Research Program

UT Southwestern lung transplant recipient lives through 19 years

Researchers identify fibronectin strain-sensitive probes

Severe fibrosis increases early atherosclerosis risk in patients with chronic HCV-1 infection

Researchers identify gene that increases risk of MI in newborns with CF

Nano-devices cross blood-brain barrier to deliver drug to treat cerebral palsy

Autophagy potential target for new CF treatments

CRF announces top 10 clinical research achievement awards

UM hosts symposium on next generation characterization tools for therapeutic proteins

Longer looks: Diagnosing autism in minutes; Finding new uses for old drugs; Cancer war victories

CLYD gene serves as crucial negative regulator in pulmonary fibrosis

CPF proclaims September as 'Pulmonary Fibrosis Awareness Month'

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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