Fluoroquinolone News and Research

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Fluoroquinolone is a type of drug used to prevent and treat infections. Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. This risk is further increased in those over age 60, in kidney, heart, and lung transplant recipients, and with use of concomitant steroid therapy.

Rising antimicrobial resistance in STIs: A call for global action

Review delves into the rising challenge of antimicrobial resistance in sexually transmitted infections, underscoring the need for innovative treatments and the critical role of global surveillance in managing diseases like gonorrhea and syphilis.

21 Mar 2024

Deep learning unlocks new antibiotic classes, revolutionizing the fight against resistance

A Nature journal study employs deep learning to analyze chemical sub-structures, leading to the discovery of new structural classes of antibiotics, showcasing the potential of AI in accelerating antibiotic development.

20 Dec 2023

Breakthrough in tuberculosis treatment: TB-PRACTECAL trial reveals efficacy of new oral regimen

The TB-PRACTECAL clinical trial outcomes, which evaluated the efficacy and safety of oral bedaquiline.

20 Nov 2023

Does your gut microbiome play a role in therapeutic outcomes?

The role of the gut microbiome and its metabolites in altering the therapeutic outcomes

12 Oct 2023

The relationship between the burden of antibiotic resistance in humans and community access to drinking water and sanitation

Researchers determined the link between improved access to sanitation and better water quality and the human intestines' antibiotic resistance gene frequency.

5 Jul 2023

Beyond expectations: study finds treatment success gap in drug-resistant Tuberculosis

Researchers performed a review of global treatment outcomes of drug-resistant Tuberculosis.

27 Jun 2023

Rapid spread of antibiotic-resistant E. coli across Europe raises concerns

Research paper highlights the swift cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area from 2012 to June 2022. The findings emphasize the need for continued surveillance and effective measures to combat the spread of antibiotic-resistant bacteria.

15 May 2023

Study reveals alarming global burden of antimicrobial resistance in bacterial infections

The paper presents a systematic analysis of the global burden of bacterial antimicrobial resistance in 2019. The authors highlight the urgent need for action to address this growing public health threat.

23 Apr 2023

Antibiotic-resistant strains of typhoid bacteria continue to spread out of South Asia

Antibiotic-resistant strains of Salmonella Typhi, the typhoid bacteria, have spread from South Asia to other countries nearly 200 times since 1990, new research suggests.

29 Jun 2022

Study assesses how vaccination against typhoid fever could help avert antimicrobial resistance

Researchers from Yale University, University of Basel, University of Antwerp, CDDEP and other institutions recently published 'Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modeling study' in The Lancet Infectious Diseases.

4 Feb 2022

Antibiotic-resistant salmonella bacteria packs a punch for U.S. travelers

One type of the salmonella bacteria is much more likely to cause disease and fend off frontline antibiotics when acquired in Europe, Asia, and parts of Africa rather than domestically in the United States.

2 Aug 2021

Study demonstrates the impact of 'reverse antibiotic' on gram-negative bacteria

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy.

5 Mar 2021

New drug cocktail offers hope to patients with highly drug-resistant tuberculosis

A new three-drug, all-oral, six-month treatment is providing hope to patients in Tajikistan with highly drug-resistant forms of tuberculosis, which until now had limited treatment options and poor prognosis.

3 Feb 2021

WHO revises definition of extensively drug-resistant tuberculosis

The definition of extensively drug-resistant tuberculosis (XDR-TB) has been revised by the World Health Organization's Global TB Programme, who have also defined pre-XDR-TB for the first time, highlighting the seriousness of these forms of TB.

1 Feb 2021

New inhibitor of SARS-CoV-2 RNA translation

As the search for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors continues, a recent study by Yale University School of Medicine researchers published on the preprint server bioRxiv in October 2020 reports the inhibitory effect of the drug merofloxacin on frameshifting during SARS-CoV-2 replication.

26 Oct 2020

Researchers successfully develop imaging technology of conjunctival goblet cells

Goblet cells are epithelial cells that produce mucins and disperse tears which help the surface of eyes maintain the wet environment. Goblet cells are closely related to autoimmune disease including dry eyes and chemical burns. Therefore, it is very important to examine the status of goblet cells to better understand and diagnose ocular disease.

5 Dec 2019

New clinical guideline for treatment of drug-resistant tuberculosis published

The American Thoracic Society, Centers for Disease Control and Prevention, European Respiratory Society and the Infectious Diseases Society of America have published an official clinical guideline on the treatment of drug-resistant tuberculosis in the Nov. 15 American Journal of Respiratory and Critical Care Medicine.

18 Nov 2019

New clinical practice guideline published for adults with community acquired pneumonia

The American Thoracic Society and the Infectious Diseases Society of America have published an official clinical guideline on the diagnosis and treatment of adults with community acquired pneumonia (CAP) in the ATS's Oct. 1 American Journal of Respiratory and Critical Care Medicine.

1 Oct 2019

Only half of patients with sinus, throat, or ear infections receive first-line antibiotics

Investigators have now shown that only half of patients presenting with sinus, throat, or ear infections at different treatment centers received the recommended first-line antibiotics, well below the industry standard of 80 percent.

25 Sep 2019

African bacterium resists almost all drugs

It looks like it’s time to pay the piper. The first extensively drug-resistant (XDR) strain of Salmonella typhimurium, called ST313 sublineage II.1, has cropped up in the Democratic Republic of Congo (DRC). This fails to respond to any of the antibiotics that are commonly used in the DRC, except for ciprofloxacin. And to make things worse, one sample has been isolated that shows incomplete response even to this last drug.

22 Sep 2019