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Second case of variant Creutzfeldt-Jakob disease infection that was probably caused by blood transfusion

Research reported in The Lancet this week details the second case of variant Creutzfeldt-Jakob disease (vCJD) infection that was probably caused by blood transfusion. The rogue prion responsible for vCJD was identified at postmortem five years after an elderly person received a blood transfusion from a donor who later developed vCJD.

5 Aug 2004

Mayo Clinic and IBM have announced a broad collaboration to accelerate advances in patient care and research

Mayo Clinic and IBM have announced a broad collaboration to accelerate advances in patient care and research with an aggressive set of technology initiatives. The goal is to take advantage of an explosion in new medical data to drive tighter linkage between research and the practice of medicine to achieve breakthroughs.

5 Aug 2004

First evidence of the molecular link between inflammation and cancer

The investigators found that a gene called I-kappa-B kinase (IKK beta), a pro-inflammatory gene, acts differently in two cell types to cause cancer. When IKK beta was deleted, the cancer incidence and tumor growth in mice was decreased by nearly 80 percent.

5 Aug 2004

Rheumatoid arthritis and early indicators of disease

A chronic autoimmune disease marked by severe inflammation and joint, rheumatoid arthritis (RA) is a major cause of pain and disability.

5 Aug 2004

Mefloquine, an anti-malarial drug plays a critical role in movement, vision and memory

Brown University researchers have discovered that mefloquine, an anti-malarial drug, blocks two gap junction proteins, or connexins, in low doses and with very few side effects in the brains of laboratory mice.

5 Aug 2004

Experimental vaccine against ricin

Scientists have developed an experimental vaccine against ricin, a potential biological threat agent, which fully protected mice from aerosol challenge with lethal doses of the toxin.

5 Aug 2004

Protein loss plays role in acute T-cell leukemia

The loss of a key protein (Smad3) in a pathway that helps prevent tumors from forming is specific to one form of childhood leukemia, but not to other pediatric and adult forms of leukemia, according to a new study published in the August 5, 2004, New England Journal of Medicine.

5 Aug 2004

New screening test for oesophageal (food pipe) cancer

A new screening test for oesophageal (food pipe) cancer could dramatically improve survival from the disease, according to research published in the British Journal of Cancer this week.

5 Aug 2004

Nogo protein may control the progression of Alzheimer’s disease

Researchers in the Department of Neurosciences at The Cleveland Clinic Lerner Research Institute have found that Nogo, a protein known for its ability to regulate nerve regeneration, may control the progression of Alzheimer’s disease.

3 Aug 2004

Smart drug that targets cancer cells in the brain following removal of a tumor

The use of a "smart" drug that targets cancer cells in the brain following removal of a tumor may provide treatment that can extend the survival of people with the most common form of primary malignant brain tumor, glioblastoma multiforme (GBM).

3 Aug 2004

Entirely new approach to the treatment of aging

Dispelling the belief that the only way to treat such conditions is by fixing or replacing damaged genes, they instead focused on the field of epigenetics—the study of changes in gene silencing that occur without changes in the genes themselves.

3 Aug 2004

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Overwhelming evidence accumulated during almost 20 years of clinical experience has established the benefits of this drug, which blocks the harmful effects of angiotensin, a substance that causes blood vessels to narrow, said the study authors.

3 Aug 2004

Switches in the brain that tell the body to stop eating and start burning calories

A Brown-led research team has discovered a pair of universal switches in the brain that tell the body to stop eating and start burning calories.

3 Aug 2004

Smart gene therapy might effectively prevent the organ damage commonly suffered by heart attack victims

Early intervention with a novel kind of "smart gene therapy" might effectively prevent the organ damage commonly suffered by heart attack victims, suggests a new animal study by researchers at Brigham and Women's Hospital in Boston and Duke University Medical Center.

2 Aug 2004

First-of-its-kind noninvasive imaging technique shows two proteins interacting

Radiologists at Washington University School of Medicine in St. Louis have developed a first-of-its-kind noninvasive imaging technique that allows them to watch two proteins interacting in live animals.

2 Aug 2004

A protein that the body uses to attack the AIDS virus is actually a stealthy defense mechanism that evolved 32 million years before HIV

A protein that the body uses to attack the AIDS virus is actually a stealthy defense mechanism that evolved 32 million years before the emergence of HIV, according to new findings from Fred Hutchinson Cancer Research Center.

2 Aug 2004

Isolated soy protein shown to benefit type 2 diabetics

Isolated soy protein added to the diets of 14 men, all military veterans under treatment for advanced stages of type 2 diabetes, significantly lowered unwanted proteins in their urine and slightly raised desired HDL cholesterol levels in their blood, researchers say.

2 Aug 2004

New approach to cancer vaccines may eradicate skin cancer tumors

Mayo Clinic and British researchers have developed a new approach to cancer vaccines that purposely kills healthy skin cells to target the immune system against tumors. The new approach has eradicated skin cancer tumors in mice.

2 Aug 2004

Scientists create mice that don't gain weight, even when fed fat-laden, high calorie diets

By altering the expression of a single -- albeit different – gene, Drs. Roger Davis (UMASS Medical School, USA) and Ying-Hue Lee (Academia Sinica, Taiwan) have succeeded in creating two different strains of transgenic mice that don't gain weight, even when fed fat-laden, high calorie diets.

2 Aug 2004

Scientists have produced a prion protein that can trigger the development of a neurological disorder similar to "mad cow" disease

Scientists have produced a prion protein that can trigger the development of a neurological disorder in mice that is similar to "mad cow" disease, according to a new study supported by the National Institute on Aging, a part of the National Institutes of Health.

2 Aug 2004

G Protein News and Research

Second case of variant Creutzfeldt-Jakob disease infection that was probably caused by blood transfusion

Mayo Clinic and IBM have announced a broad collaboration to accelerate advances in patient care and research

First evidence of the molecular link between inflammation and cancer

Rheumatoid arthritis and early indicators of disease

Mefloquine, an anti-malarial drug plays a critical role in movement, vision and memory

Experimental vaccine against ricin

Protein loss plays role in acute T-cell leukemia

New screening test for oesophageal (food pipe) cancer

Nogo protein may control the progression of Alzheimer’s disease

Smart drug that targets cancer cells in the brain following removal of a tumor

Entirely new approach to the treatment of aging

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Switches in the brain that tell the body to stop eating and start burning calories

Smart gene therapy might effectively prevent the organ damage commonly suffered by heart attack victims

First-of-its-kind noninvasive imaging technique shows two proteins interacting

A protein that the body uses to attack the AIDS virus is actually a stealthy defense mechanism that evolved 32 million years before HIV

Isolated soy protein shown to benefit type 2 diabetics

New approach to cancer vaccines may eradicate skin cancer tumors

Scientists create mice that don't gain weight, even when fed fat-laden, high calorie diets

Scientists have produced a prion protein that can trigger the development of a neurological disorder similar to "mad cow" disease

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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