GPCR News and Research

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U-M scientists develop new tool to better understand neuronal signaling

University of Michigan researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons.

23 Apr 2024

ApoA-IV surge after bariatric surgery enhances insulin secretion and energy expenditure

Bariatric surgery has emerged as an effective means of reducing weight in morbidly obese individuals, while also significantly improving diabetes. Currently, laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) are two of the most commonly performed bariatric surgeries.

18 Apr 2024

Study reveals structural dynamics of key hearing receptor

Professor Yunje Cho's research team from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH, Republic of Korea) has collaborated with Professor Kwang Pyo Kim's group from the Department of Applied Chemistry at Kyung Hee University (KHU, ROK), Professor Vsevolod Katritch's team from the University of Southern California (USC, USA), and Professor Carol V. Robinson from the University of Oxford (UK) to uncover the mysteries surrounding a specific receptor protein associated with hearing.

15 Apr 2024

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

15 Mar 2024

Deciphering the role of GPCRs in obesity pathology for drug development

Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity.

5 Mar 2024

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury.

27 Feb 2024

Mitochondria on the move: New discovery could revolutionize treatment of brain diseases

The human brain is an organ that takes nearly from 20 to 25% of the energy the body needs. This high energy demand for neuronal functions depends on the transport and precise distribution of mitochondria — the energy-generating cell organelles — in each neuron.

7 Feb 2024

Hamamatsu introduces the New FDSS-GX: the highest-performance kinetic plate imager in the FDSS series

Hamamatsu Photonics announces the release of a new high-speed kinetic plate imager, the FDSS-GX.

From Hamamatsu Photonics Europe 5 Feb 2024

UH researcher aims to revolutionize treatment regimens for triple-negative breast cancer

A researcher at the University of Houston College of Pharmacy Drug Discovery Institute is working to revolutionize treatment regimens for triple-negative breast cancer (TNBC) by proving that nebivolol, an FDA-approved drug for high blood pressure, is effective in treating it.

31 Jan 2024

St. Jude announces $13 million investment to expand the understanding of G-protein coupled receptors

St. Jude Children's Research Hospital today announced a nearly $13 million investment toward a new research collaboration with scientists at Columbia University, Duke University and Stanford University to expand the understanding of G-protein coupled receptors (GPCR), which are vital proteins that impact human health and disease.

18 Jan 2024

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Researchers identified 5-hydroxytryptamine 2A (5-HT2A) receptor (5-HT2AR) signaling pathways associated with psychedelic potential.

19 Dec 2023

MedUni Vienna scientists discover new pain medication with fewer side effects

People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects.

6 Dec 2023

Scientists unlock secrets of preeclampsia

Preeclampsia is a mysterious condition that occurs in about one of 10 pregnancies without any early warning signs.

1 Dec 2023

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Dietary components that impact anti-tumor immunity.

28 Nov 2023

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women's increased risk for the disease and its severity.

21 Nov 2023

GPCR News and Research

U-M scientists develop new tool to better understand neuronal signaling

ApoA-IV surge after bariatric surgery enhances insulin secretion and energy expenditure

Study reveals structural dynamics of key hearing receptor

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Deciphering the role of GPCRs in obesity pathology for drug development

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Mitochondria on the move: New discovery could revolutionize treatment of brain diseases

Hamamatsu introduces the New FDSS-GX: the highest-performance kinetic plate imager in the FDSS series

UH researcher aims to revolutionize treatment regimens for triple-negative breast cancer

St. Jude announces $13 million investment to expand the understanding of G-protein coupled receptors

St. Jude researchers crack the code of the β2-adrenergic receptor

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

MedUni Vienna scientists discover new pain medication with fewer side effects

Scientists unlock secrets of preeclampsia

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

New AI tool could lead to precision medicine by predicting drug response

Newly discovered nanobody may lead to a treatment for Retinitis Pigmentosa

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

New process can help to design drugs with fewer or no side effects

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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