Gastrointestinal Tract News and Research

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Study reveals the determinants of persistent and severe COVID-19

As COVID-19 wreaks havoc across the globe, one characteristic of the infection has not gone unnoticed. The disease is heterogeneous in nature with symptoms and severity of the condition spanning a wide range.

5 Oct 2022

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

One reason that it's so difficult to deliver large protein drugs orally is that these drugs can't pass through the mucus barrier that lines the digestive tract.

28 Sep 2022

uPAR may be a promising target for therapy in patients with neuroendocrine neoplasms

A novel PET radiotracer can accurately assess the presence of a biomarker that indicates the level of tumor aggressiveness in neuroendocrine neoplasms (NENs).

28 Sep 2022

Orally ingestible robotic drug delivery device overcomes barriers of the gastrointestinal environment

Oral drug delivery is the most common and cost-effective way to deliver a treatment. But drugs must make it through the harsh, acidic environment of the stomach, resist degradation by enzymes, penetrate the barrier posed by the mucus of the small intestine and overcome many other obstacles before they can be absorbed.

28 Sep 2022

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Radhakrishna Rao, PhD, vice-chair and professor in the Department of Physiology at the University of Tennessee Health Science Center (UTHSC), has received two large national awards totaling $5 million for separate studies involving the gut as a therapeutic target for treating disease.

26 Sep 2022

Two waves of Pitx2 expression orchestrate gut rotation during development, study finds

Our guts, and all our organs, are arranged in left-right asymmetric patterns inside our bodies, so that everything may fit.

23 Sep 2022

Soy protein diet increases susceptibility to Clostridioides difficile infection

According to a recent study published in the journal Cell Reports, a diet rich in soy protein increases human Clostridioides difficile susceptibility by increasing the gut amino acids (AAs) levels and promoting the growth of Lactobacillus.

18 Sep 2022

Nutritional approaches targeting gut microbiome could improve brain disorders

A new review published in the Clinical Nutrition and Metabolic Care journal focused on studies that utilized the dietary gut microbiota–target interventions to improve mental health conditions. It also discussed some suggestions for developing more robust and informative interventions for diet–microbiome studies.

15 Sep 2022

Understanding what happens when two gut microbiomes clash together

Fecal microbiota transplantation (FMT) – the transfer of lower intestinal fluids and microbes from one individual to another – is sometimes used to treat inflammatory gut diseases, including ulcerative colitis and bacterial infections.

15 Sep 2022

Research identifies a promising path to developing therapies to treat esophageal tumors

Research led by Case Western Reserve University has identified a promising path to developing therapies to treat esophageal tumors––a form of cancer that not only is among the most deadly, but also has been occurring at increasing rates over the past decade.

8 Sep 2022

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Researchers review current knowledge regarding the generation of immune memory responses and their durability post-infection and vaccination.

7 Sep 2022

Discovery sheds light on an important aspect of gut health and mucosal immunity

Immune cells called group 3 innate lymphoid cells (ILC3s) play an essential role in establishing tolerance to symbiotic microbes that dwell in the human gastrointestinal tract, according to a study led by researchers at Weill Cornell Medicine.

7 Sep 2022

Recent developments in the use of nanoparticles to deliver drugs to the brain via intranasal administration

Scientists have recently reviewed research articles related to the application of inorganic nanoparticles in delivering drugs to the brain through the intranasal route.

7 Sep 2022

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Researchers performed the photocatalytic mapping of the SARS-CoV-2 spike protein-host cell membrane interactions.

7 Sep 2022

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease.

29 Aug 2022

New treatment may help counteract food allergies and inflammatory diseases in future

Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences.

22 Aug 2022

Researchers find rebleeding rates and predictors for obscure gastrointestinal bleeding

Obscure gastrointestinal bleeding (OGIB) is defined as gastrointestinal bleeding from a source that cannot be determined even after upper or lower gastrointestinal endoscopy is performed.

19 Aug 2022

New method helps identify which gut microbes most likely contribute to inflammatory diseases

Cedars-Sinai investigators have developed a method to help identify which human gut microbes are most likely to contribute to a slew of inflammatory diseases like obesity, liver disease, inflammatory bowel disease, cancer and some neurological diseases.

17 Aug 2022

New simulator quantifies the effect of body posture and stomach motility on drug bioavailability

A common, economic, and easy method of administering drugs is orally, by swallowing a pill or capsule.

9 Aug 2022

Fatigue and headache among the most common symptoms following COVID-19 infections

Fatigue and headache were the most common symptoms reported by individuals an average of more than four months out from having COVID-19, investigators report.

8 Aug 2022

Gastrointestinal Tract News and Research

Study reveals the determinants of persistent and severe COVID-19

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

uPAR may be a promising target for therapy in patients with neuroendocrine neoplasms

Orally ingestible robotic drug delivery device overcomes barriers of the gastrointestinal environment

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Two waves of Pitx2 expression orchestrate gut rotation during development, study finds

Soy protein diet increases susceptibility to Clostridioides difficile infection

Nutritional approaches targeting gut microbiome could improve brain disorders

Understanding what happens when two gut microbiomes clash together

Research identifies a promising path to developing therapies to treat esophageal tumors

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Discovery sheds light on an important aspect of gut health and mucosal immunity

Recent developments in the use of nanoparticles to deliver drugs to the brain via intranasal administration

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

New treatment may help counteract food allergies and inflammatory diseases in future

Researchers find rebleeding rates and predictors for obscure gastrointestinal bleeding

New method helps identify which gut microbes most likely contribute to inflammatory diseases

New simulator quantifies the effect of body posture and stomach motility on drug bioavailability

Fatigue and headache among the most common symptoms following COVID-19 infections

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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