Gene Therapy News and Research

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Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery.

LEDGF protein controls the location of HIV integration in human cells

A human DNA-associated protein called LEDGF is the first such molecule found to control the location of HIV integration in human cells, according to researchers at the University of Pennsylvania School of Medicine.

5 Dec 2005

Artificial mammalian origin of replication

A collaboration of researchers from Harvard Medical School and the University of Virginia, led by Dr. Anindya Dutta, has created an artificial mammalian origin of replication that will facilitate the future study of mammalian DNA replication.

2 Dec 2005

GRK5's role in restenosis

Researchers at Jefferson Medical College have begun to clarify the role of a protein - and potential drug target - in the process by which arteries re-clog after treatment.

28 Nov 2005

GRK2 protein - potential drug target for heart failure

A protein that plays an important regulatory role in heart failure in the heart also exerts powerful effects on the adrenal gland, Jefferson Medical College researchers have found. The protein, GRK2, is a potential drug target for heart failure.

28 Nov 2005

Gene therapy potential of the protein vasostatin for treatment of pancreatic cancer

A gene responsible for the production of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print in Gut.

15 Nov 2005

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Gene therapy and exercise may help sufferers of Lou Gehrig's disease

A new study in mice gives hope that a combination of gene therapy and exercise may extend the lives of people who have Lou Gehrig's disease.

15 Nov 2005

Biomedical device allows stem cells derived from adult bone marrow to be grown in sufficient quantities to permit far more research

Human stem cells offer tremendous hope for the development of revolutionary medical treatments for these and a variety of other human health problems.

14 Nov 2005

Molecular origins of diabetes

An unexpected twist to a discovery reported just two months ago may significantly improve our understanding about the molecular origins of diabetes.

14 Nov 2005

University of Alberta researchers pioneer gene therapy to restore alveoli and lung capillaries in damaged rat lungs

The good news is that medical advances in perinatal care have allowed us to save many more premature babies. The bad news is they're often at risk of developing bronchopulmonary dysplasia--a chronic lung disease caused by having to place the tiny infants on ventilators and oxygen-rich therapy for acute respiratory failure.

13 Nov 2005

Pretreating a vein graft with edifoligide prior to coronary bypass graft surgery does not lower the rate of graft failure

Coronary artery bypass graft (CABG) surgery is one of the most common surgical procedures performed in the United States, according to background information in the article. In appropriately selected patients, CABG surgery results in improved survival, relief of angina, and improved quality of life. Despite frequent use of artery grafts, vein grafts remain the most frequently used conduit.

13 Nov 2005

Introgen's INGN 241 combined with Celebrex kills breast cancer cells

Introgen Therapeutics, Inc. today reported the publication of preclinical data demonstrating that INGN 241 works synergistically with celecoxib (Celebrex) marketed by Pfizer to inhibit the growth and increase apoptosis (cell death) of breast cancer cells.

8 Nov 2005

Those most at risk of Alzheimer's would allow loved ones enroll them in research

According to a new survey most people at high risk of Alzheimer's disease would be willing to have their loved ones enroll them in research studies when they could no longer give consent themselves.

8 Nov 2005

Cell fusion triggered by viruses is a possible contributing factor in the development of human cancer

In some cases, the fusion of human cells is a normal process that leads, for instance, to the formation of muscle and bone. Viral infections can also cause cell fusion, but cells fused by viruses are widely considered to be harmless because they are generally believed to die without consequences for the host.

7 Nov 2005

Should Alzheimer's sufferers take part in research?

Grandma has Alzheimer's disease - should you sign her up for a new research study, even if she doesn't really understand what it entails?

7 Nov 2005

Research project to advance understanding of how cancer cells evade the immune system

A pre-clinical research project coordinated by The University of Manchester, which will advance understanding of how cancer cells evade the immune system, has been awarded nearly 12m Euro by the EU.

From The University of Manchester 7 Nov 2005

Gene doping is a real danger - but anti-doping science is making progress

Gene therapy research has reached a critical phase. Already practised on humans as part of strictly controlled experiments, gene therapy promises to become a widely available form of treatment for injury and disease.

7 Nov 2005

First steps taken to treat human hereditary blindness

A team led by Krzysztof Palczewski, Ph.D., chair of pharmacology at the Case Western Reserve University School of Medicine, has taken the first steps in treating an eye disease causing irreversible congenital blindness in millions of people worldwide by successfully testing two new treatments in mice.

3 Nov 2005

Treatment for Leber Congenital Amaurosis

U.S. researchers have taken the first steps in treating an eye disease that causes irreversible blindness in humans by successfully testing two novel treatments in mice.

1 Nov 2005

New understanding of how neurogenesis occurs

Scientists at the Salk Institute for Biological Studies have identified a crucial cellular signal that controls the fate of stem cells in the brains of adult mice.

27 Oct 2005

Gene Therapy News and Research

Further Reading

LEDGF protein controls the location of HIV integration in human cells

Artificial mammalian origin of replication

GRK5's role in restenosis

GRK2 protein - potential drug target for heart failure

Gene therapy potential of the protein vasostatin for treatment of pancreatic cancer

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Gene therapy and exercise may help sufferers of Lou Gehrig's disease

Biomedical device allows stem cells derived from adult bone marrow to be grown in sufficient quantities to permit far more research

Molecular origins of diabetes

University of Alberta researchers pioneer gene therapy to restore alveoli and lung capillaries in damaged rat lungs

Pretreating a vein graft with edifoligide prior to coronary bypass graft surgery does not lower the rate of graft failure

Introgen's INGN 241 combined with Celebrex kills breast cancer cells

Those most at risk of Alzheimer's would allow loved ones enroll them in research

Cell fusion triggered by viruses is a possible contributing factor in the development of human cancer

Should Alzheimer's sufferers take part in research?

Research project to advance understanding of how cancer cells evade the immune system

Gene doping is a real danger - but anti-doping science is making progress

First steps taken to treat human hereditary blindness

Treatment for Leber Congenital Amaurosis

New understanding of how neurogenesis occurs

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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