Gene Transfer News and Research

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Gene Transfer is the insertion of genetic material into a cell.

Modulating T-cell response: Innovations in AAV8 gene therapy for retinal diseases

A new study shows that subretinal adeno-associated virus 8 (AAV8) injections cause proinflammatory T-cell immune response against the transgene product.

19 Jul 2024

Diabetes decoded: How your gut microbiome influences disease risk

How microbial features and functions specific to subspecies and strains contribute to the pathological mechanisms of type 2 diabetes.

27 Jun 2024

Microplastics in rivers harbor unique microbial communities, spreading antibiotic resistance

Researchers discovered distinct bacterial and viral communities on microplastics in the Beilun River, highlighting potential health risks and the spread of antibiotic-resistance genes.

17 Jun 2024

Foam technology revolutionizes gene therapy, boosting efficiency and safety

Liquid foam gene delivery significantly enhances transfection efficiency and safety, offering a cost-effective alternative to conventional methods.

3 Jun 2024

Foam-based delivery system could revolutionize gene therapies

Foam mixed with medications is already used to treat conditions such as varicose veins, hemorrhoids, wounds on the skin and even hair loss.

29 May 2024

Intracellular protein delivery with HyNT stamp system: A leap forward in cancer therapy

The intracellular delivery of proteins is an important technique for unveiling the cellular functions, protein complex structure, and therapeutics. However, the conventional delivery methods have several limitations.

20 May 2024

Meta-analysis reveals drivers of antibiotic resistance in infants

A meta-analysis of genetic studies analyzing the microbiota (bacteria in the gut) of 1,275 infants from 10 countries finds that cesarean delivery and antibiotic use are driving the increase of antibiotic resistance genes load among infants, according to new research being presented at this year's ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April).

24 Apr 2024

Rising antibiotic resistance prompts shift to ecological research strategies in infection control

The need to enhance research on the interactions between bacterial pathogens and commensals within human microbiomes.

12 Apr 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Novel genetic mechanisms of tetracycline resistance in gut bacteria discovered

Antibiotic resistance is a significant and growing medical problem worldwide. Researchers at the Marine Biological Laboratory (MBL) and collaborators have found a novel genetic arrangement that may help a common bacterium in the human gut, Bacteroides fragilis, protect itself from tetracycline, a widely used antibiotic.

1 Mar 2024

Key link discovered between spread of antibiotic resistance genes and drug resistance evolution

Biomedical engineers at Duke University have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens.

23 Feb 2024

Ancient DNA reveals syphilis-like disease in pre-Columbian America

Researchers at the Universities of Basel and Zurich have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago.

24 Jan 2024

€1.6M project aims to crack the code of degradation-resistant tumors

An international research project on the subject of "Understanding and targeting degradation-resistant tumors" has been granted funding of 1.655 million euros through the German-Israeli Project Cooperation (DIP) program.

11 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Machine learning unlocks secrets of antimicrobial resistance, identifying over 900 key genes

Researchers employed advanced techniques like gene annotation, pangenomics, and machine learning to identify over 900 genes responsible for antimicrobial resistance in 12 bacterial species, outperforming traditional identification methods. This breakthrough approach offers new insights into the genetic basis of resistance, potentially guiding the development of more effective antibiotics

27 Nov 2023

Genetics and sedimentology combined to refine cyanobacteria biomarker diagnostics

Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems.

27 Oct 2023

Gene therapy breakthrough: Scientists develop method to deliver larger genes to target cells

Gene therapy currently represents the most promising approach for the treatment of hereditary diseases. Yet despite significant breakthroughs in recent years, there are still a number of hurdles that hinder the wider application of gene therapies.

24 Oct 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023