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Scientists adopt fresh approach in quest for new therapies

Scientists are to pool their expertise in human health to pioneer an innovative approach to treating common diseases.

27 Nov 2007

Discovery of key acute myeloid leukemia gene

A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.

27 Nov 2007

Insulin regulates the secretion of the antiaging hormome Klotho

Dr. Carmela Abraham, a professor of biochemistry and medicine at Boston University School of Medicine (BUSM), reports this week in the Proceedings of the National Academy of Sciences new findings on Klotho, an anti-aging gene that is associated with life span extension in rodents and humans.

27 Nov 2007

Blood-vessel blocker aids cancer-killing virus

Cancer-killing viruses are a promising therapy for incurable brain tumors, but their effectiveness has been limited in part because immune cells rapidly move in and eliminate them.

27 Nov 2007

Australian researcher heralds a golden age in biomedical science

A senior University of Sydney researcher has heralded a 'golden age' of modern biochemistry and molecular biology brought about by our complete sequencing of the human genome.

27 Nov 2007

Wyeth receives European approval for TORISEL

Wyeth Pharmaceuticals, a division of Wyeth, has announced that the European Commission has approved TORISEL (temsirolimus) for the first-line treatment of patients with advanced renal cell carcinoma (RCC) who have at least three of six prognostic risk factors. TORISEL is the only approved cancer therapy that specifically inhibits the mTOR (mammalian target of rapamycin) kinase, an important regulator of cell proliferation, cell growth and cell survival.

27 Nov 2007

New disease model for Huntington's

Huntington's disease is a genetic time bomb: Programmed in the genes, it appears at a predictable age in adulthood, causing a progressive decline in mental and neurological function and finally death.

27 Nov 2007

More evidence that biological factors play a significant role in the development of sexual orientation

A study of men in Ontario, Canada provides a new twist on the connection between sexual/relational orientation and right or left-handedness.

27 Nov 2007

Flip-flopping gene expression can be advantageous

One gene for pea pod color generates green pods while a variant of that gene gives rise to the yellow-pod phenotype, a feature that helped Gregor Mendel, the 19th century Austrian priest and scientist, first describe genetic inheritance.

27 Nov 2007

Brain pattern associated with genetic risk of obsessive compulsive disorder

Cambridge researchers have discovered that individuals with obsessive compulsive disorder (OCD) and their close family members have distinctive patterns in their brain structure.

27 Nov 2007

Antidepressant drugs MAY make you live longer

American researchers are suggesting that antidepressant drugs may possibly lengthen a person's lifespan.

26 Nov 2007

Mutant mice could provide genetic clues on human sight loss

Mutant mice could provide genetic clues to understanding incurable human sight loss resulting from retinal degeneration.

22 Nov 2007

Discovery of new signaling molecule could lead to the development of new treatments for cancer

Investigators at St. Jude Children's Research Hospital have discovered a new signaling molecule that prevents immune responses from running amok and damaging the body.

21 Nov 2007

Peptide therapy used to prevent progression of Parkinson's

Researchers have successfully used a peptide to reverse biochemical, cellular and anatomical changes that occur in the brains of mice with Parkinson's disease (PD), and report success in preventing the disease from progression.

21 Nov 2007

First genome sequence of XDR strain of the bacterium Mycobacterium tuberculosis

An international collaboration led by researchers in the US and South Africa today announced the first genome sequence of an extensively drug resistant (XDR) strain of the bacterium Mycobacterium tuberculosis, one linked to more than 50 deaths in a recent tuberculosis (TB) outbreak in KwaZulu-Natal, South Africa.

21 Nov 2007

Scientists identify key nerve navigation pathway

Newly launched nerve cells in a growing embryo must chart their course to distant destinations, and many of the means they use to navigate have yet to surface.

21 Nov 2007

There is a new twist on the question of how biological clocks work

In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite a number of hypotheses, exactly how the microscopic pacemakers in every cell in the body exert such a widespread influence has remained a mystery.

21 Nov 2007