Genetic News and Research

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Abbott, GenLab collaborate to develop new assay for PLEX-ID automated microbial identification system

Abbott announced today it will collaborate with Genetics Laboratory, Inc. on the development of a molecular diagnostic test that will be designed to rapidly detect microorganisms that cause orthopedic infections.

5 Mar 2012

Tips to assess when gambling could be leading to process addiction

Whether it's a March Madness office betting pool or sitting in the sports books in Las Vegas placing bets on the Masters Golf Tournament and opening week of Major League Baseball, the coming months are fraught with sporting events which lure millions of gamblers to place their bets.

5 Mar 2012

R-loop formation may drive under-methylation and autoimmunity

Researchers at the University of California, Davis, have figured out how the human body keeps essential genes switched "on" and silences the vast stretches of genetic repeats and "junk" DNA.

3 Mar 2012

WUSTL scientists to decode DNA of 99 patients with rare diseases

Rare genetic diseases, long overlooked because they affect relatively few people, are getting new attention. Scientists at Washington University School of Medicine in St. Louis are reaching out to patient advocacy groups and offering to decode the DNA of 99 patients with rare diseases to help find the genetic alterations responsible for their illnesses.

3 Mar 2012

REST molecule acts as an adapter in stem cells, times neuronal development

Upon fertilisation, a single cell is formed when egg and sperm fuse. Our entire body, with more than 200 specialised cell types and billions of cells are formed from this single cell. It is a scientific mystery how the early stem cells know what cell type to become, but a precise timing of the process is crucial for correct development and function of our body.

3 Mar 2012

Critical new details about structure of enterovirus 71

Researchers have discovered critical new details about the structure of a virus that causes potentially fatal brain swelling and paralysis in children, pointing toward designs for antiviral drugs to treat the disease.

3 Mar 2012

New ACR classification criteria for polymyalgia rheumatica

The American College of Rheumatology has released the first classification criteria for polymyalgia rheumatica - aimed at helping physicians identify patients with this condition, which occurs in persons aged 50 years or older who have recent onset of pain in the shoulders, neck and hips along with other inflammatory symptoms not explained by an alternate diagnosis.

2 Mar 2012

Call for Expression of Interest to attend personalised medicine conference

The Call for Expression of Interest to attend or present at the Conference on Personalised Medicine: Better Healthcare in Cyprus in June 2012 is now open. The deadline is 1 April 2012.

2 Mar 2012

Review highlights potential strategies for treatment of Down syndrome, AD

Down syndrome (DS) is the most common genetic disorder in live born children arising as a consequence of a chromosomal abnormality. It occurs as a result of having three copies of chromosome 21, instead of the usual two. It causes substantial physical and behavioral abnormalities, including life-long cognitive dysfunction that can range from mild to severe but which further deteriorates as individuals with DS age.

2 Mar 2012

First study to focus on platelet genetics in African Americans

Researchers, led by scientists from Johns Hopkins, have found five previously unknown gene mutations believed to be associated with elevated blood platelet counts in African-Americans, findings they say could someday lead to the development of new drugs to help prevent coronary artery disease.

2 Mar 2012

Planarian flatworms reveal new insights into stem cell biology

Devising a novel method to identify potential genetic regulators in planarian stem cells, Whitehead Institute scientists have determined which of those genes affect the two main functions of stem cells. Three of the genes are particularly intriguing because they code for proteins similar to those known to regulate mammalian embryonic stem cells. Such genetic similarity makes planarians an even more attractive model for studying stem cell biology in vivo.

2 Mar 2012

Alternative subunits generate different functional subtypes of RNA polymerases

Indiana University biologists have found that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can differ in function based on variation in the parts -- in this case protein subunits -- used to assemble those machines.

2 Mar 2012

Scientists identify genetic defect responsible for TAR Syndrome

Universitätsmedizin Berlin in collaboration with the Sanger Institute in Cambridge and other cooperation partners in Belgium, the Netherlands and France, were able to identify a genetic defect that is responsible for the development of TAR Syndrome, a congenital malformation of the skeleton and blood.

1 Mar 2012

Metastatic melanoma patients with specific genetic mutation benefit from vemurafenib

A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib - increasing median survival from about 6 months to 15.9 months. In patients who responded, the drug stopped cancer progression for a median 6.7 months.

1 Mar 2012

Public agencies must study ecological risks of synthetic biology

Experts say at least $20 million to $30 million in government research is needed over the next decade to adequately identify and address the possible ecological risks of synthetic biology, an emerging area of research focused on the design and construction of new biological parts and systems, or modification of existing ones, to create new applications in areas ranging from energy to chemicals and pharmaceuticals.

1 Mar 2012

New data on how genes and age influence AD plaque deposition

When 225 researchers from around the world convened in Miami to exchange the latest on β amyloid positron emission tomography in January, there was a palpable sense of urgency. At the 6th Annual Human Amyloid Imaging (HAI) Conference, the possibility of approval, potentially within months, of the first amyloid-scanning compound for clinical use hung over the room.

1 Mar 2012

TWRI team develops new drug against damaging effects of stroke

Scientists at the Toronto Western Research Institute (TWRI), Krembil Neuroscience Center, have developed a drug that protects the brain against the damaging effects of a stroke in a lab setting. This drug has been in development for a few years.

1 Mar 2012

KF's TBI research director to speak at Washington conference

Jordan Grafman, PhD, director of Traumatic Brain Injury Research at Kessler Foundation, is an invited speaker at The 2nd Annual Traumatic Brain Injury Conference on March 6, 2012, in Washington, DC. Dr. Grafman will describe the long-term cognitive and social consequences of traumatic brain injury.

1 Mar 2012

Study focuses on genetic markers in the diagnosis of autism

Cleveland Clinic Children's Hospital has launched a study to determine whether genetic markers can be used to help identify children who are at risk of developing autism.

1 Mar 2012

HDAC2 enzyme could be a potential target for new Alzheimer's drugs

MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms.

1 Mar 2012