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Scientists identify unusual mutations in endometriosis using gene sequencing tools

Using gene sequencing tools, scientists from Johns Hopkins Medicine and the University of British Columbia have found a set of genetic mutations in samples from 24 women with benign endometriosis, a painful disorder marked by the growth of uterine tissue outside of the womb.

11 May 2017

Deep-learning network provides accurate detection and delineation of breast cancers on biopsy slides

A deep-learning computer network developed through research led by Case Western Reserve University was 100 percent accurate in determining whether invasive forms of breast cancer were present in whole biopsy slides.

11 May 2017

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced an exclusive, global collaboration and license agreement for the development and commercialization of gene therapy programs for Hemophilia A, including SB-525, one of Sangamo's four lead product candidates, which Sangamo expects will enter the clinic this quarter.

11 May 2017

CNIO researchers optimize new system capable of generating cellular model of Ewing sarcoma

A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma.

10 May 2017

Studies pave way for genome-targeted treatments in pancreatic cancer

University of Pittsburgh and UPMC researchers are paving the way for genome-targeted treatments in pancreatic cancer, an especially deadly form of cancer with few existing therapeutic options, according to a pair of recent studies.

9 May 2017

New research could lead to improved therapies for global parasitic disease

Recently published research from Iowa State University biomedical scientists details new methods for studying a parasitic nematode that sickens millions worldwide, a development that could lead to improved therapies.

9 May 2017

New UCI Malaria Initiative aims to disrupt deadly disease transmission in Africa

University of California, Irvine vector biologist Anthony James will lead a multimillion-dollar effort to cultivate new strains of mosquitoes to fight malaria in Africa.

9 May 2017

Researchers develop fast algorithm that provides new insights into protein evolution

Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet.

9 May 2017

Vitamin A deficiency leads to loss of blood stem cells

Many specialized cells, such as in the skin, gut or blood, have a lifespan of only a few days. Therefore, steady replenishment of these cells is indispensable. They arise from so-called "adult" stem cells that divide continuously.

5 May 2017

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Recurrence of head and neck squamous cell carcinoma (HNSCC) negative for human papillomavirus (HPV) following radiation therapy was associated with high tumor levels of the protein PD-L1.

5 May 2017

New conference aims to improve understanding of how advances in genomics influence society

From prenatal genetic screening to the genetic testing of women with family histories of breast cancer, genomics is rapidly becoming a fixture in our lives.

5 May 2017

Genetic study outlines path to personalize breast cancer risk assessment and treatment

Although the odds of developing breast cancer are nearly identical for black and white women, black women are 42 percent more likely to die from the disease. This mortality gap – driven by social and environmental, as well as biological factors – continues to persist.

4 May 2017

International consensus addresses research bottlenecks to diagnose rare genetic diseases

A worldwide consensus co-authored by more than 40 scientists sets out ways to address research bottlenecks as the international community strives to diagnose most rare genetic diseases by 2020.

4 May 2017

Scientists uncover thousands of human genes that are expressed differently in the two sexes

Men and women differ in obvious and less obvious ways -- for example, in the prevalence of certain diseases or reactions to drugs. How are these connected to one's sex? Weizmann Institute of Science researchers recently uncovered thousands of human genes that are expressed -- copied out to make proteins -- differently in the two sexes.

4 May 2017

$New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds$

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

A team of researchers of the University of Barcelona and the Hospital del Mar Medical Research Institute have discovered a new mutation that has an impact on the bone so that it is vulnerable to the bisphosphonate, a drug used to treat osteoporosis.

4 May 2017

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

A new study published in the journal Molecular Therapy reveals that HIV DNA in the genome of living animals can be removed to eliminate further infection. While a permanent cure for infection caused by HIV remains a challenge due to the ability of the virus to hide away in latent reservoirs. The study team comprising Wenhui Hu, Kamel Khalili, Laura H. Carnell, and Won-Bin Young carried out an experiment on three different animal models.

4 May 2017

Lethal DNA re-replication may be used to attack cancer cells

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise to aberrant cells as those detected in many carcinomas.

4 May 2017

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

10x Genomics, a company focused on enabling the mastery of biology by accelerating genomic discovery, today announced publication of an article in the journal Nature of a collaborative research study with researchers at the Stanford University School of Medicine.

From 10x Genomics, Inc. 4 May 2017

Study sets stage for potential stool-based test to detect advanced liver fibrosis

Nonalcoholic fatty liver disease (NAFLD) - a condition that can lead to liver cirrhosis and cancer -; isn't typically detected until it's well advanced. Even then, diagnosis requires an invasive liver biopsy.

2 May 2017

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

The formation of a human embryo starts with the fertilization of the oocyte by the sperm cell. This yields the zygote, the primordial cell that carries one copy each of the maternal and paternal genomes.

2 May 2017

Genome News and Research

Scientists identify unusual mutations in endometriosis using gene sequencing tools

Deep-learning network provides accurate detection and delineation of breast cancers on biopsy slides

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

CNIO researchers optimize new system capable of generating cellular model of Ewing sarcoma

Studies pave way for genome-targeted treatments in pancreatic cancer

New research could lead to improved therapies for global parasitic disease

New UCI Malaria Initiative aims to disrupt deadly disease transmission in Africa

Researchers develop fast algorithm that provides new insights into protein evolution

Vitamin A deficiency leads to loss of blood stem cells

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

New conference aims to improve understanding of how advances in genomics influence society

Genetic study outlines path to personalize breast cancer risk assessment and treatment

International consensus addresses research bottlenecks to diagnose rare genetic diseases

Scientists uncover thousands of human genes that are expressed differently in the two sexes

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

Lethal DNA re-replication may be used to attack cancer cells

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

Study sets stage for potential stool-based test to detect advanced liver fibrosis

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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