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Innovative array targets methylation in imprinted genes, simplifies epigenetic research

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome.

25 Jul 2024

New insights into how genetic variants influence disease risk

A new study by scientists at deCODE Genetics, a subsidiary of Amgen, shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and other human traits.

25 Jul 2024

Comprehensive analysis of Alzheimer’s brain tissue identifies novel biomarkers

From studying the human genome, to analyzing the way proteins are encoded, or monitoring RNA expression, researchers are rapidly gaining a far richer understanding of the complex genetic and cellular mechanisms that underpin dementia. But there's a catch: While new technologies are revealing myriad avenues for Alzheimer's research, it's impossible to know in advance which research pathways will lead to effective treatments.

25 Jul 2024

'Gene misbehavior' found to be surprisingly common among the healthy population

Scientists have uncovered that 'gene misbehavior' – where genes are active when they were expected to be switched off – is a surprisingly common phenomenon in the healthy human population.

24 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's-;and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Researchers develop accurate and rapid method for diagnosing genetic disorders

Despite rapid advances in genetic testing in recent decades, more than half of people worldwide with suspected Mendelian genetic disorders do not have an accurate molecular diagnosis.

23 Jul 2024

GeneMAP: A new tTool for mapping metabolic gene functions

There's a glaring gap in our knowledge of cell metabolism: in many cases, we still don't know exactly how nutrients are transported into the cell.

23 Jul 2024

Genetic and molecular risk factors discovered for subsequent stroke and MACE

People who experience an arterial ischemic stroke (AIS) or transient ischemic stroke (TIA) are at an increased risk of suffering a second stroke or other major adverse cardiovascular event (MACE), making it critically important to identify risk factors and treatments to prevent these subsequent occurrences.

22 Jul 2024

Research uncovers dengue’s surprising invasion strategies

Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease.

22 Jul 2024

Innovative genetic approaches to rare disease diagnosis

The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example by means of exome sequencing (ES), leading to a molecular genetic diagnosis.

22 Jul 2024

Challenges and opportunities in rare tumor research

Ning Li et al., at Chinese Academy of Medical Sciences and Peking Union Medical College, China, provides a comprehensive review on the challenges and opportunities in the field of rare tumor research and management.

22 Jul 2024

High mutation count in new COVID-19 variants does not increase immune evasion, study finds

New research from UNC Charlotte's Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) has found that the two recent and prevalent strains of the virus that cause COVID-19, SARS-CoV-2 variants BA.2.86 and JN.1, are not significantly better than their predecessor Omicron at evading immune responses and causing infections despite having a high number of mutations compared to Omicron.

19 Jul 2024

Study highlights the link between urinary and vaginal pathogenic E. coli in recurrent cystitis

The human body hosts a diverse array of microorganisms that maintain a delicate balance crucial for overall health.

19 Jul 2024

Elite Controllers: Do their genomes hold the key to curing HIV?

Although South Africa has the largest number of people living with HIV worldwide, strides have been made in controlling the epidemic, especially in the reduction of HIV incidence, testing, and treatment. Equipped with MGI’s advanced sequencing tools and technologies, researchers from the South African Medical Research Council (SAMRC) and University of KwaZulu-Natal (UKZN) are inching closer to finding the answer to the natural control of HIV infection, leading to improved health outcomes and quality of life amongst South Africans.

From MGI 19 Jul 2024

Expanding genetic Horizons: GWAS insights from the VA Million Veterans Program

A large-scale genome-wide association study (GWAS) using data from the United States Department of Veterans Affairs (VA) Million Veterans Program (MVP) – one of the largest US-based biobanks – fills crucial gaps in our knowledge of the relationships between genes, traits, and disease across diverse populations, according to a new study.

19 Jul 2024

Tiny animals steal antibiotic secrets from bacteria to fight disease

A group of small, freshwater animals protect themselves from infections using antibiotic recipes "stolen" from bacteria, according to new research by a team from the University of Oxford, the University of Stirling and the Marine Biological Laboratory (MBL), Woods Hole.

19 Jul 2024

Ginseng genome unlocks secrets of medicinal benefits

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine. This pivotal discovery promises to drive forward breeding initiatives and augment the plant's medicinal qualities, unlocking new possibilities for therapeutic applications.

19 Jul 2024