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Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Mitochondrial disorders are a chameleon-like set of diseases that take many different forms and vary widely from individual to individual.

12 Jul 2016

Research findings unveil new avenues to monitor, treat lung cancer more effectively

A team of researchers from Singapore has discovered a class of small RNA molecules, known as oncomiRs, which are responsible for fuelling lung cancer.

12 Jul 2016

Recellularized colon model helps identify cancer driver genes involved in CRC progression

Genetic mutations are a major cause of cancer, and tracking the role of each gene in cancer pathogenesis has long been an important tool in the fight against a disease that is expected to kill more than 1.6 million people this year.

11 Jul 2016

Gut bacteria can help predict susceptibility to rheumatoid arthritis

The bacteria in your gut do more than break down your food. They also can predict susceptibility to rheumatoid arthritis, suggests Veena Taneja, Ph.D., an immunologist at Mayo Clinic's Center for Individualized Medicine. Dr. Taneja recently published two studies — one in Genome Medicine and one in Arthritis and Rheumatology — connecting the dots between gut microbiota and rheumatoid arthritis.

11 Jul 2016

UTSA researcher elucidates innovative strategies to track disease-causing pathogens

In a new study published in Frontiers in Microbiology, Mark Eppinger, assistant professor in the Department of Biology at The University of Texas at San Antonio describes innovative strategies to track disease-causing pathogens like E. coli. Eppinger hopes his research will aid in halting and preventing large-scale outbreaks.

11 Jul 2016

JAX researchers find precise, reliable way to identify leukemia cells of origin

Every cancer starts with a single cell, and Jackson Laboratory researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome.

11 Jul 2016

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

Columbia University Medical Center and Weill Cornell Medicine, in collaboration with NewYork-Presbyterian and NYC Health + Hospitals/Harlem, have been awarded a grant from the NIH for approximately $4 million in fiscal year 2016 to enroll participants in the Cohort Program of President Barack Obama's Precision Medicine Initiative (PMI)—a large-scale research effort to improve our ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics.

11 Jul 2016

New diagnostic blood test may offer hope for transplant recipients through analysis of cfDNA

When cells die, whether through apoptosis or necrosis, the DNA and other molecules found in those cells don't just disappear. They wind up in the blood stream, where degraded bits and pieces can be extracted.

8 Jul 2016

Research opens up new ways to detect, inhibit cancer spread

Clusters of circulating cells commonly found in the blood of cancer patients have long been the subject of research on cancer. These clusters have been regarded for more than 50 years as malignant cells that have broken off from the primary tumor, spreading cancer to other parts of the body.

8 Jul 2016

New genetic test provides rapid diagnosis of mitochondrial disease

Newcastle researchers have developed a genetic test providing a rapid diagnosis of mitochondrial disorders to identify the first patients with inherited mutations in a new disease gene.

7 Jul 2016

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Inherited mutations in genes that function to repair DNA may contribute to metastatic prostate cancer more than previously recognized, according to a study out today in the New England Journal of Medicine.

7 Jul 2016

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But current methods fall short of the precision needed.

6 Jul 2016

Penn researchers develop low-cost genetic test for Zika virus

University of Pennsylvania engineers have developed a rapid, low-cost genetic test for the Zika virus.

6 Jul 2016

Scientists discover new genetic variations linked to increased myeloma risk

Researchers have identified eight new genetic variations in the human genome that could be linked to an increased risk of developing myeloma. The findings provide additional evidence and build on existing research that suggests myeloma can run in families.

5 Jul 2016

Tiny viruses speed-up evolution of bacteria causing infections in cystic fibrosis patients

SCIENTISTS in the UK have found new evidence that tiny viruses called bacteriophages turbo-charge the evolution of bacteria that cause lung infections in Cystic Fibrosis patients.

5 Jul 2016

Novel technique could help discover genes linked to complex traits in any animal model

Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. Yet genomic studies in mice have lagged behind those in humans.

4 Jul 2016

Researchers identify non-coding RNA NEAT1 as potential drug target to combat cancer

A team of researchers led by professor Jean-Christophe Marine has identified NEAT1, a non-coding RNA, as a potential therapeutic target in the fight against cancer.

4 Jul 2016

Recommendations for integrating genomic results into clinical practice

A quiet transformation has been brewing in medicine, as large-scale DNA results become increasingly available to patients and healthcare providers.

1 Jul 2016

Kataegis linked to better prognosis for breast cancer patients

Kataegis is a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome. The anomaly was previously found in some cancers, but it has been unclear what role kataegis plays in tumor development and patient outcomes.

1 Jul 2016

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature.

From Bruker BioSpin - NMR, EPR and Imaging 30 Jun 2016

Genome News and Research

Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Research findings unveil new avenues to monitor, treat lung cancer more effectively

Recellularized colon model helps identify cancer driver genes involved in CRC progression

Gut bacteria can help predict susceptibility to rheumatoid arthritis

UTSA researcher elucidates innovative strategies to track disease-causing pathogens

JAX researchers find precise, reliable way to identify leukemia cells of origin

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

New diagnostic blood test may offer hope for transplant recipients through analysis of cfDNA

Research opens up new ways to detect, inhibit cancer spread

New genetic test provides rapid diagnosis of mitochondrial disease

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Penn researchers develop low-cost genetic test for Zika virus

Scientists discover new genetic variations linked to increased myeloma risk

Tiny viruses speed-up evolution of bacteria causing infections in cystic fibrosis patients

Novel technique could help discover genes linked to complex traits in any animal model

Researchers identify non-coding RNA NEAT1 as potential drug target to combat cancer

Recommendations for integrating genomic results into clinical practice

Kataegis linked to better prognosis for breast cancer patients

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

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